Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74.


:Not all patients with type 2 diabetes develop renal dysfunction. Identifying those at risk is problematic because even microalbuminuria, often used clinically as an indicator of future renal dysfunction, does not always precede worsening renal function. We sought to identify clinical risk factors at diagnosis of type 2 diabetes associated with later development of renal dysfunction. Of 5,102 U.K. Prospective Diabetes Study (UKPDS) participants, prospective analyses were undertaken in those without albuminuria (n = 4,031) or with normal plasma creatinine (n=5,032) at diagnosis. Stepwise proportional hazards multivariate regression was used to assess association of putative baseline risk factors with subsequent development of albuminuria (microalbuminuria or macroalbuminuria) or renal impairment (Cockcroft-Gault estimated creatinine clearance <60 ml/min or doubling of plasma creatinine). Over a median of 15 years of follow-up 1,544 (38%) of 4,031 patients developed albuminuria and 1,449 (29%) of 5,032 developed renal impairment. Of 4,006 patients with the requisite data for both outcomes, 1,534 (38%) developed albuminuria and 1,132 (28%) developed renal impairment. Of the latter, 575 (51%) did not have preceding albuminuria. Development of albuminuria or renal impairment was independently associated with increased baseline systolic blood pressure, urinary albumin, plasma creatinine, and Indian-Asian ethnicity. Additional independent risk factors for albuminuria were male sex, increased waist circumference, plasma triglycerides, LDL cholesterol, HbA(1c) (A1C), increased white cell count, ever having smoked, and previous retinopathy. Additional independent risk factors for renal impairment were female sex, decreased waist circumference, age, increased insulin sensitivity, and previous sensory neuropathy. Over a median of 15 years from diagnosis of type 2 diabetes, nearly 40% of UKPDS patients developed albuminuria and nearly 30% developed renal impairment. Distinct sets of risk factors are associated with the development of these two outcomes, consistent with the concept that they are not linked inexorably in type 2 diabetes.






Retnakaran R,Cull CA,Thorne KI,Adler AI,Holman RR,UKPDS Study Group.




Has Abstract


2006-06-01 00:00:00
















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    abstract::Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: van de Weijer T,Phielix E,Bilet L,Williams EG,Ropelle ER,Bierwagen A,Livingstone R,Nowotny P,Sparks LM,Paglialunga S,Szendroedi J,Havekes B,Moullan N,Pirinen E,Hwang JH,Schrauwen-Hinderling VB,Hesselink MK,Auwerx J,Ro

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  • Prospective study of microalbuminuria as predictor of mortality in NIDDM.

    abstract::Retrospective studies of patients with non-insulin-dependent diabetes mellitus (NIDDM) have suggested that microalbuminuria predicts early all-cause (mainly cardiovascular) mortality independently of arterial blood pressure. These findings have not been confirmed in prospective studies, and it is not known whether the...


    pub_type: 杂志文章


    authors: Mattock MB,Morrish NJ,Viberti G,Keen H,Fitzgerald AP,Jackson G

    更新日期:1992-06-01 00:00:00

  • Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats.

    abstract::Treatment of male sand rats kept on a balanced laboratory chow diet ad libitum with beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a hypolipidemic effect accompanied by an extensive reduction in adiposity, with a concomitant hypoglycemic-hypoinsulinemic effect. The overall effect was s...


    pub_type: 杂志文章


    authors: Tzur R,Rose-Kahn G,Adler JH,Bar-Tana J

    更新日期:1988-12-01 00:00:00

  • Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.

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    pub_type: 杂志文章


    authors: Ghosh S,Lertwattanarak R,Lefort N,Molina-Carrion M,Joya-Galeana J,Bowen BP,Garduno-Garcia Jde J,Abdul-Ghani M,Richardson A,DeFronzo RA,Mandarino L,Van Remmen H,Musi N

    更新日期:2011-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Griffith RC,Scharp DW,Hartman BK,Ballinger WF,Lacy PE

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    pub_type: 杂志文章


    authors: Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

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  • Reduction and recovery of plasma 1,5-anhydro-D-glucitol level in diabetes mellitus.

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    pub_type: 杂志文章


    authors: Yamanouchi T,Akanuma H,Asano T,Konishi C,Akaoka I,Akanuma Y

    更新日期:1987-06-01 00:00:00

  • T-lymphocyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects.

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    pub_type: 杂志文章


    authors: Faustman D,Schoenfeld D,Ziegler R

    更新日期:1991-05-01 00:00:00

  • Rapid increase in circulating leptin in ventromedial hypothalamus-lesioned rats: role of hyperinsulinemia and implication for upregulation mechanism.

    abstract::The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...


    pub_type: 杂志文章


    authors: Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

    更新日期:1999-10-01 00:00:00

  • Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.

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    pub_type: 杂志文章


    authors: Casas S,Gomis R,Gribble FM,Altirriba J,Knuutila S,Novials A

    更新日期:2007-09-01 00:00:00

  • Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.

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    pub_type: 杂志文章


    authors: Yeh LA,Rafford CE,Goddu KJ,Ashton MA,Beyer TA,Hutson NJ

    更新日期:1987-12-01 00:00:00

  • Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis.

    abstract::One hundred fifty-four selected patients with nonketotic diabetes diagnosed between the ages of 35 and 75 yr and treated with diet or oral hypoglycemic agents for at least 1 yr were investigated for parameters of glycemic control (weight loss, blood glucose, and glycosylated hemoglobin), islet cell function (fasting a...


    pub_type: 杂志文章


    authors: Groop LC,Bottazzo GF,Doniach D

    更新日期:1986-02-01 00:00:00

  • Normoglycemia after reflux of islet-containing pancreatic fragments into the splenic vascular bed in dogs.

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    pub_type: 杂志文章


    authors: Warnock GL,Rajotte RV,Procyshyn AW

    更新日期:1983-05-01 00:00:00

  • Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes.

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    authors: Emanuelli B,Glondu M,Filloux C,Peraldi P,Van Obberghen E

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  • Increased hemoglobin AIc in diabetic mice.

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    pub_type: 杂志文章


    authors: Koenig RJ,Araujo DC,Cerami A

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  • Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice.

    abstract::Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) allevia...


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    authors: Nagata N,Xu L,Kohno S,Ushida Y,Aoki Y,Umeda R,Fuke N,Zhuge F,Ni Y,Nagashimada M,Takahashi C,Suganuma H,Kaneko S,Ota T

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  • Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day.

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    pub_type: 杂志文章


    authors: Moore MC,Smith MS,Farmer B,Kraft G,Shiota M,Williams PE,Cherrington AD

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  • Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Greenwood RH,Ireland JT,Jones DH,Mahler RF

    更新日期:1975-11-01 00:00:00

  • Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue.

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    pub_type: 杂志文章


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    更新日期:2009-03-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Bock T,Pakkenberg B,Buschard K

    更新日期:2005-01-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

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