Effects of insulin on rat anterior pituitary cells. Inhibition of growth hormone secretion and mRNA levels.

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00

abstract：:Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportun...

journal_title：Diabetes

authors： Boden G,Chen X,Urbain JL

更新日期：1996-08-01 00:00:00

abstract：:This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is als...

journal_title：Diabetes

authors： Stewart AF,Hussain MA,García-Ocaña A,Vasavada RC,Bhushan A,Bernal-Mizrachi E,Kulkarni RN

更新日期：2015-06-01 00:00:00

abstract：:We tested 32 routine clinical parameters for their ability to discriminate between a high risk and a low risk of non-insulin-dependent diabetes mellitus (NIDDM) within 5-7 years after pregnancies complicated by gestational diabetes mellitus (GDM). Latino women (n = 671) with GDM who did not have diabetes 4-16 weeks af...

journal_title：Diabetes

authors： Kjos SL,Peters RK,Xiang A,Henry OA,Montoro M,Buchanan TA

更新日期：1995-05-01 00:00:00

abstract：:Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to determine whether such alterations are present during the initial stages of insulin resistance in hum...

journal_title：Diabetes

authors： Fisher-Wellman KH,Weber TM,Cathey BL,Brophy PM,Gilliam LA,Kane CL,Maples JM,Gavin TP,Houmard JA,Neufer PD

更新日期：2014-01-01 00:00:00

abstract：:In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...

journal_title：Diabetes

authors： Harada K,Shimano H,Ishibashi S,Yamada N

更新日期：1996-07-01 00:00:00

abstract：:Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown. In this study, we showed that fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to ad...

journal_title：Diabetes

authors： Kuang J,Zhang Y,Liu Q,Shen J,Pu S,Cheng S,Chen L,Li H,Wu T,Li R,Li Y,Zou M,Zhang Z,Jiang W,Xu G,Qu A,Xie W,He J

更新日期：2017-05-01 00:00:00

abstract：:Longitudinal electron-microscopic and morphometric studies of autonomic nerves containing predominantly parasympathetic fibers were undertaken in the spontaneously diabetic BB rat. Unmyelinated fibers of the diabetic vagus nerve and myelinated fibers of the penile nerve showed increased numbers of axonal glycogenosome...

journal_title：Diabetes

authors： Yagihashi S,Sima AA

更新日期：1986-07-01 00:00:00

abstract：:During the development to overt nephropathy, diabetic patients go through several characteristic stages of renal disease, moving from normo- to micro- to macroalbuminuria. Microalbuminuria is defined as a urinary albumin excretion between 20 and 200 microg/min; values <20 microg/min are designated as normoalbuminuria,...

journal_title：Diabetes

authors： Mogensen CE

更新日期：1997-09-01 00:00:00

abstract：:The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of r...

journal_title：Diabetes

authors： Gilbert RE

更新日期：2017-04-01 00:00:00

abstract：:A role for glucose in the control of feeding has been proposed, but its precise physiological importance is unknown. Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (ripglut1;glut2-/- mice). We showed that in the abs...

journal_title：Diabetes

authors： Bady I,Marty N,Dallaporta M,Emery M,Gyger J,Tarussio D,Foretz M,Thorens B

更新日期：2006-04-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:By closing ATP-sensitive K+ (K+-ATP) channels, glucose promotes depolarization-dependent Ca2+ entry and cytoplasmic free Ca2+ concentration ([Ca2+]i) rise in beta-cells. Ca2+-dependent exocytosis of insulin granules is then potentiated by a K+-ATP channel-independent action of glucose. The underlying mechanisms of thi...

journal_title：Diabetes

authors： Sato Y,Henquin JC

更新日期：1998-11-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：:Plasma dopamine-beta-hydroxylase (pDBH) activity is markedly elevated in chronic experimental streptozotocin (STZ) diabetes in the rat. Several possible explanations, all potentially relevant to the pathophysiology of diabetes, could explain this observation. The objective of this paper was to further delineate the be...

journal_title：Diabetes

authors： Schmidt RE,Geller DM,Johnson EM Jr

更新日期：1981-05-01 00:00:00

abstract：:Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...

journal_title：Diabetes

authors： Rickels MR,Fuller C,Dalton-Bakes C,Markmann E,Palanjian M,Cullison K,Tiao J,Kapoor S,Liu C,Naji A,Teff KL

更新日期：2015-05-01 00:00:00

abstract：:The early steps of insulin biosynthesis occur in the endoplasmic reticulum (ER), and the beta-cell has a highly developed and active ER. All cells regulate the capacity of their ER to fold and process client proteins and they adapt to an imbalance between client protein load and folding capacity (so-called ER stress)....

journal_title：Diabetes

authors： Harding HP,Ron D

更新日期：2002-12-01 00:00:00

abstract：:The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a prote...

journal_title：Diabetes

authors： Zhuang H,Bhattacharjee A,Hu F,Zhang M,Goswami T,Wang L,Wu S,Berggren PO,Li M

更新日期：2000-01-01 00:00:00

abstract：:Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat (ATF) were measured using a computed tomography scan, both before (baseline) and after (post) a 20-week endurance exercise training protocol in the HERITAGE Family Study. Each of the baseline and response (post minus baseline) meas...

journal_title：Diabetes

authors： Rice T,Chagnon YC,Pérusse L,Borecki IB,Ukkola O,Rankinen T,Gagnon J,Leon AS,Skinner JS,Wilmore JH,Bouchard C,Rao DC

更新日期：2002-03-01 00:00:00

abstract：:Insulin secretion from the pancreas is pulsatile. The precise site and function of the pacemaker that regulates insulin periodicity in humans have not been determined. We isolated human pancreatic islets from five cadaver organ donors by collagenase digestion and density gradient purification. After 24 h of culture in...

journal_title：Diabetes

authors： Marchetti P,Scharp DW,Mclear M,Gingerich R,Finke E,Olack B,Swanson C,Giannarelli R,Navalesi R,Lacy PE

更新日期：1994-06-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00

abstract：:A 21-year-old female patient complaining of frequent hypoglycemic attacks in the presence of a large amount of circulating insulin-binding antibodies without previous known immunization is described. In order to clarify the possible mechanism of the hypoglycemic attacks occurring in this new syndrome, changes in plasm...

journal_title：Diabetes

authors： Ichihara K,Shima K,Saito Y,Nonaka K,Tarui S

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in these mice. RESEARCH DESIGN AND METHODS:DIO mice were separated in two groups according to body weig...

journal_title：Diabetes

authors： Peyot ML,Pepin E,Lamontagne J,Latour MG,Zarrouki B,Lussier R,Pineda M,Jetton TL,Madiraju SR,Joly E,Prentki M

更新日期：2010-09-01 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：:In this study, 92% of patients' serums known to contain antibodies against islet cells, including the Juvenile Diabetes Foundation provisional reference serum, had antibodies reacting with gastrointestinal carcinoid tumors. Twelve percent of the control serums from healthy individuals bound to carcinoid cells, and 2% ...

journal_title：Diabetes

authors： Miettinen A,Holthöfer H,Kontiainen S,Miettinen M,Andersson LC

更新日期：1989-05-01 00:00:00

abstract：:Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. This review will address the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis...

journal_title：Diabetes

authors： Havel PJ

更新日期：2004-02-01 00:00:00

abstract：:Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...

journal_title：Diabetes

authors： Friedman JE

更新日期：2018-11-01 00:00:00

abstract：:Increased susceptibility of LDL to oxidation has been shown to be associated with the presence of coronary heart disease and may account for the accelerated vascular disease seen in diabetes. The response of LDL to in vitro oxidative stress has been proposed as a measure of the predisposition of LDL to the in vivo sub...

journal_title：Diabetes

authors： Jenkins AJ,Klein RL,Chassereau CN,Hermayer KL,Lopes-Virella MF

更新日期：1996-06-01 00:00:00

abstract：:The incretin hormones, glucagon-like peptide 1 and pituitary adenylyl cyclase-activating polypeptide, are proposed to activate a maitotoxin (MTX)-sensitive, Ca2+-dependent nonselective cation current in pancreatic beta-cells and insulinoma cells. This MTX-sensitive current is present in human beta-cells as well as in ...

journal_title：Diabetes

authors： Leech CA,Habener JF

更新日期：1998-07-01 00:00:00