Abstract:
:In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min) to somatostatin normalized basal glucagon levels and resulted in a significant and sustained hyperglycemia. During the first 2 h, hyperglycemia was mainly due to increased glucose production, whereas later on it was maintained by decreased glucose uptake. We conclude that, in man moderately deprived of insulin, even a marginal change in glucagon level induces a long-lasting hyperglycemia.
journal_name
Diabetesjournal_title
Diabetesauthors
Lins PE,Wajngot A,Adamson U,Vranic M,Efendić Sdoi
10.2337/diab.32.7.633subject
Has Abstractpub_date
1983-07-01 00:00:00pages
633-6issue
7eissn
0012-1797issn
1939-327Xjournal_volume
32pub_type
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