Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control.

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：:One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive oxygen species as signals. In isolated mouse islets and INS-1(832/13) cells, glucose increase...

journal_title：Diabetes

authors： Pi J,Bai Y,Zhang Q,Wong V,Floering LM,Daniel K,Reece JM,Deeney JT,Andersen ME,Corkey BE,Collins S

更新日期：2007-07-01 00:00:00

abstract：:The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1.B and RT1.D. The possibility that variant or unique class II MHC molecules m...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK

更新日期：1989-02-01 00:00:00

abstract：:To clarify the event that is involved in the pathogenesis of impaired glucose tolerance (IGT), we studied 15 individuals with IGT and 15 subjects with normal tolerance using the minimal model approach. Our IGT subjects were characterized by normal insulin secretory responses to oral glucose and mild impairments in ins...

journal_title：Diabetes

authors： Taniguchi A,Nakai Y,Doi K,Fukushima M,Nagata I,Kawamura H,Imura H,Suzuki M,Tokuyama K

更新日期：1994-10-01 00:00:00

abstract：:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and a...

journal_title：Diabetes

authors： Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EA

更新日期：1993-04-01 00:00:00

abstract：:Myo-Inositol depletion as a result of hyperglycemia is considered one of the leading contributors to chronic diabetic complications. We investigated the possible mechanisms through which elevated extracellular glucose levels affect the loss of intracellular myo-inositol in rat lens. Short-term incubation (up to 4 h) i...

journal_title：Diabetes

authors： Mistry KP,Beyer-Mears A,Diecke FP

更新日期：1993-12-01 00:00:00

abstract：:Incubation of 3T3-L1 adipocytes with C2- and C6-ceramides (N-acetyl- and N-hexanoylsphingosines) but not dihydro-C2-ceramide increased 2-deoxyglucose uptake in the absence of insulin. This effect was inhibited by PD 98059, LY 294002, and rapamycin, which block the activation of mitogen-activated protein kinase, phosph...

journal_title：Diabetes

authors： Wang CN,O'Brien L,Brindley DN

更新日期：1998-01-01 00:00:00

abstract：:Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic ...

journal_title：Diabetes

authors： Hand MS,Surwit RS,Rodin J,Van Order P,Feinglos MN

更新日期：1987-03-01 00:00:00

abstract：:The effects of ethanol, acetaldehyde, and the two novel metabolites of ethanol 2,3-butanediol and 1,2-propanediol on basal and insulin-stimulated adipocyte lipogenesis and glucose oxidation in vitro were investigated. Whereas ethanol and acetaldehyde inhibited both processes at concentrations far greater than those fo...

journal_title：Diabetes

authors： Lomeo F,Khokher MA,Dandona P

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:The efficacy of gangliosides in enhancing axonal regeneration and maturation in the early stages of diabetic neuropathy was assessed by quantitative analysis of immunostained serial sections of the sciatic nerve. Sprague-Dawley rats were made diabetic with a single injection of alloxan (100 mg/kg). One week later they...

journal_title：Diabetes

authors： Triban C,Guidolin D,Fabris M,Marini P,Schiavinato A,Donà M,Bortolami MC,Di Giamberardino L,Fiori MG

更新日期：1989-08-01 00:00:00

abstract：:In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with sh...

journal_title：Diabetes

authors： Rodriguez-Calvo T,Krogvold L,Amirian N,Dahl-Jørgensen K,von Herrath M

更新日期：2021-01-07 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps ...

journal_title：Diabetes

authors： Hamid YH,Urhammer SA,Jensen DP,Glümer C,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：:Repeated large-volume blood withdrawals started at a young age previously appeared to correct lymphopenia and prevent diabetes in Ottawa diabetes-prone BB (BBdp) rats. Therefore, we sought an early effect 24 h after withdrawal of 25% of estimated blood volume and then reexamined the long-term effects in BBdp rats. The...

journal_title：Diabetes

authors： Marliss EB,Métroz-Dayer MD,Montambault M,Faucher M,Grose M

更新日期：1990-09-01 00:00:00

abstract：:We performed a variance components linkage analysis of renal function, measured as glomerular filtration rate (GFR), in 63 extended families with multiple members with type 2 diabetes. GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives. Results for cy...

journal_title：Diabetes

authors： Placha G,Poznik GD,Dunn J,Smiles A,Krolewski B,Glew T,Puppala S,Schneider J,Rogus JJ,Rich SS,Duggirala R,Warram JH,Krolewski AS

更新日期：2006-12-01 00:00:00

abstract：:Insulin receptors from rat hepatoma cells (Fao) and human placenta were partially purified by detergent solubilization and lectin purification. The insulin receptor preparations were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under reducing or nonreducing conditions. The proteins were...

journal_title：Diabetes

authors： Maron R,Kahn CR,Jacobs S,Fujita-Yamaguchi Y

更新日期：1984-10-01 00:00:00

abstract：:Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin-resistant, and predisposed to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then it has become in...

journal_title：Diabetes

authors： Ruderman N,Chisholm D,Pi-Sunyer X,Schneider S

更新日期：1998-05-01 00:00:00

abstract：:Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...

journal_title：Diabetes

authors： Zacharova J,Chiasson JL,Laakso M,STOP-NIDDM Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Using the euglycemic-hyperinsulinemic glucose clamp and the human forearm technique, we have demonstrated that the improved glucose disposal rate observed after the administration of an angiotensin-converting enzyme (ACE) inhibitor such as captopril may be primarily due to increased muscle glucose uptake (MGU). These ...

journal_title：Diabetes

authors： Dietze GJ,Wicklmayr M,Rett K,Jacob S,Henriksen EJ

更新日期：1996-01-01 00:00:00

abstract：:Representative longitudinal muscle strips (6 x 10 mm) from distal small intestine were obtained from rats after 1, 2, and 3 mo of streptozocin-induced diabetes. The strips were stretched to their optimum lengths and subjected to electrical field stimulation (1-ms pulse duration, 30-270 mA, 10 Hz) in the presence of Kr...

journal_title：Diabetes

authors： Nowak TV,Harrington B,Kalbfleisch J

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by at...

journal_title：Diabetes

authors： McGillicuddy FC,Harford KA,Reynolds CM,Oliver E,Claessens M,Mills KH,Roche HM

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic insulin resistance. However, growth retardation is only reported with ho...

journal_title：Diabetes

authors： Suliman SG,Stanik J,McCulloch LJ,Wilson N,Edghill EL,Misovicova N,Gasperikova D,Sandrikova V,Elliott KS,Barak L,Ellard S,Volpi EV,Klimes I,Gloyn AL

更新日期：2009-12-01 00:00:00

abstract：:Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the si...

journal_title：Diabetes

authors： He C,Li H,Viollet B,Zou MH,Xie Z

更新日期：2015-12-01 00:00:00

abstract：:The identity of the cells responsible for beta-cell destruction in type I (insulin-dependent) diabetes is still uncertain. L3T4+ T-lymphocytes have a role in the initiation of insulitis and in damaging transplanted allogeneic islets in nonobese diabetic (NOD) mice. The role of L3T4+ T-lymphocytes in destruction of bet...

journal_title：Diabetes

authors： Charlton B,Mandel TE

更新日期：1988-08-01 00:00:00

abstract：:It is suggested that the maternal transmission of islet autoantibodies increases the risk of autoimmune diabetes in mice. The aim of this study was to determine whether fetal exposure to islet autoantibodies modified the risk of type 1 diabetes in humans. Islet autoantibodies were measured at birth in 720 offspring of...

journal_title：Diabetes

authors： Koczwara K,Bonifacio E,Ziegler AG

更新日期：2004-01-01 00:00:00

abstract：:Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In prelim...

journal_title：Diabetes

authors： Gedulin BR,Young AA

更新日期：1998-01-01 00:00:00

abstract：:GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at low risk of diabetes...

journal_title：Diabetes

authors： Williams AJ,Lampasona V,Schlosser M,Mueller PW,Pittman DL,Winter WE,Akolkar B,Wyatt R,Brigatti C,Krause S,Achenbach P,Participating Laboratories.

更新日期：2015-09-01 00:00:00

abstract：:The current study investigated the fate of a [U-(13)C]palmitate tracer extracted by forearm muscle in type 2 diabetic and control subjects. We studied seven healthy lean male subjects and seven obese male subjects with type 2 diabetes using the forearm muscle balance technique with continuous intravenous infusion of t...

journal_title：Diabetes

authors： Blaak EE,Wagenmakers AJ

更新日期：2002-03-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:We examined the effects of activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice and investigated the mechanisms by which they improve insulin sensitivity. PPARalpha activation by its agonist, Wy-14,643, as well as PPARgamma activat...

journal_title：Diabetes

authors： Tsuchida A,Yamauchi T,Takekawa S,Hada Y,Ito Y,Maki T,Kadowaki T

更新日期：2005-12-01 00:00:00