Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.

abstract：:Sorbitol accumulation, myo-inositol depletion, and reduced Na+-K+-ATPase activity have been identified in experimental diabetes in several tissues in which diabetic complications occur. However, a reduction in renal Na+-K+-ATPase activity has not been universally reported, prompting us to examine the influence of diab...

journal_title：Diabetes

authors： Cohen MP,Klepser H

更新日期：1988-05-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to dete...

journal_title：Diabetes

authors： Cheung CYY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CHY,Kwok KHM,Chow WS,Woo YC,Yuen MMA,Cherny SS,Hai J,Cheung BMY,Tan KCB,Lam TH,Tse HF,Sham PC,Lam KSL

更新日期：2017-06-01 00:00:00

abstract：:Not all patients with type 2 diabetes develop renal dysfunction. Identifying those at risk is problematic because even microalbuminuria, often used clinically as an indicator of future renal dysfunction, does not always precede worsening renal function. We sought to identify clinical risk factors at diagnosis of type ...

journal_title：Diabetes

authors： Retnakaran R,Cull CA,Thorne KI,Adler AI,Holman RR,UKPDS Study Group.

更新日期：2006-06-01 00:00:00

abstract：:Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...

journal_title：Diabetes

authors： Thelin MA,Kissler S,Vigneault F,Watters AL,White D,Koshy ST,Vermillion SA,Mooney DJ,Serwold T,Ali OA

更新日期：2017-08-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00

abstract：:Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

journal_title：Diabetes

authors： Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

更新日期：2012-11-01 00:00:00

abstract：:Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent a...

journal_title：Diabetes

authors： Alto N,Carlisle Michel JJ,Dodge KL,Langeberg LK,Scott JD

更新日期：2002-12-01 00:00:00

abstract：:Studies in rodents suggest that insulin controls hepatic glucose metabolism through brain-liver crosstalk, but human studies using intranasal insulin to mimic central insulin delivery have provided conflicting results. In this randomized controlled crossover trial, we investigated the effects of intranasal insulin on ...

journal_title：Diabetes

authors： Gancheva S,Koliaki C,Bierwagen A,Nowotny P,Heni M,Fritsche A,Häring HU,Szendroedi J,Roden M

更新日期：2015-06-01 00:00:00

abstract：:This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogeneous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showin...

journal_title：Diabetes

authors： Xiang K,Wang Y,Zheng T,Jia W,Li J,Chen L,Shen K,Wu S,Lin X,Zhang G,Wang C,Wang S,Lu H,Fang Q,Shi Y,Zhang R,Xu J,Weng Q

更新日期：2004-01-01 00:00:00

abstract：:At rest and during exercise, chronic hyperglycemia, high free fatty acid (FFA) oxidation, and insulin deficiency in diabetes are well known to impair glucose clearance (metabolic clearance rate [MCR]). The effect of acute restoration of glycemia per se on MCR has been less well characterized. We therefore studied norm...

journal_title：Diabetes

authors： Fisher SJ,Lekas M,Shi ZQ,Bilinski D,Carvalho G,Giacca A,Vranic M

更新日期：1997-11-01 00:00:00

abstract：:Clinical studies indicate that significant loss of functional islet mass occurs in the peritransplant period. Islets are injured as a result of detrimental effects of brain death, pancreas preservation, islet isolation, hypoxia, hyperglycemia, and immune-mediated events. In addition, recent studies demonstrated that i...

journal_title：Diabetes

authors： Contreras JL,Eckstein C,Smyth CA,Bilbao G,Vilatoba M,Ringland SE,Young C,Thompson JA,Fernández JA,Griffin JH,Eckhoff DE

更新日期：2004-11-01 00:00:00

abstract：:Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

journal_title：Diabetes

authors： Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

更新日期：2020-02-01 00:00:00

abstract：:Autoantibodies to glutamic acid decarboxylase (GAD) are frequent at or before the onset of insulin-dependent diabetes mellitus (IDDM). We have developed a simple, reproducible, and quantitative immunoprecipitation radioligand assay using as antigen in vitro transcribed and translated [35S]methionine-labeled human isle...

journal_title：Diabetes

authors： Petersen JS,Hejnaes KR,Moody A,Karlsen AE,Marshall MO,Høier-Madsen M,Boel E,Michelsen BK,Dyrberg T

更新日期：1994-03-01 00:00:00

abstract：:The identity of the cells responsible for beta-cell destruction in type I (insulin-dependent) diabetes is still uncertain. L3T4+ T-lymphocytes have a role in the initiation of insulitis and in damaging transplanted allogeneic islets in nonobese diabetic (NOD) mice. The role of L3T4+ T-lymphocytes in destruction of bet...

journal_title：Diabetes

authors： Charlton B,Mandel TE

更新日期：1988-08-01 00:00:00

abstract：:Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable h...

journal_title：Diabetes

authors： Fatehi M,Raja M,Carter C,Soliman D,Holt A,Light PE

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and development of the dia...

journal_title：Diabetes

authors： Wong FS,Siew LK,Scott G,Thomas IJ,Chapman S,Viret C,Wen L

更新日期：2009-05-01 00:00:00

abstract：:Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive. We aimed to define monocyte COX expression in type...

journal_title：Diabetes

authors： Beyan H,Goodier MR,Nawroly NS,Hawa MI,Bustin SA,Ogunkolade WB,Londei M,Yousaf N,Leslie RD

更新日期：2006-12-01 00:00:00

abstract：:The farnesoid X receptor (FXR) and the liver x receptors (LXRs) are bile acid-activated receptors that are highly expressed in the enterohepatic tissues. The mechanisms that support the beneficial effects of bariatric surgery are only partially defined. We have investigated the effects of ileal interposition (IT), a s...

journal_title：Diabetes

authors： Mencarelli A,Renga B,D'Amore C,Santorelli C,Graziosi L,Bruno A,Monti MC,Distrutti E,Cipriani S,Donini A,Fiorucci S

更新日期：2013-10-01 00:00:00

abstract：:We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

journal_title：Diabetes

authors： Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：:Obesity is a common problem in Western society and is associated with significant morbidity and mortality. Energy homeostasis is regulated by a complex system involving both peripheral signals such as leptin and a number of orexigenic and anorectic neuropeptides. Obesity can result from dysregulation of the peripheral...

journal_title：Diabetes

authors： Bradley RL,Kokkotou EG,Maratos-Flier E,Cheatham B

更新日期：2000-07-01 00:00:00

abstract：:Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...

journal_title：Diabetes

authors： Henquin JC,Ishiyama N,Nenquin M,Ravier MA,Jonas JC

更新日期：2002-02-01 00:00:00

abstract：:A recent study has demonstrated secondary amyloidosis in dogs treated with continuous intravenous insulin infusion. Since elevated levels of serum amyloid A protein (SAA) and diminished amyloid fibril degrading activity (AFDA) are associated with amyloidosis, we measured SAA and AFDA in ten type I diabetics treated wi...

journal_title：Diabetes

authors： Koivisto VA,Teppo AM,Maury CP,Taskinen MR

更新日期：1983-01-01 00:00:00

abstract：:Although the biochemical mechanism by which insulin and contractile activity affect protein turnover in muscle are still unclear, certain physiologic conclusions can be made; (a) Increased work can induce muscle hypertrophy even in the diabetic or starving animal. Thus, work-induced growth differs from normal growth o...

journal_title：Diabetes

authors： Goldberg AL

更新日期：1979-01-01 00:00:00

abstract：:Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, a key component of the immunosuppressiv...

journal_title：Diabetes

authors： Zhang N,Su D,Qu S,Tse T,Bottino R,Balamurugan AN,Xu J,Bromberg JS,Dong HH

更新日期：2006-09-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little is known about their effect on islet function and beta-cell viability. In this study, we report that tacrolimus, sirolimus, and mycophenol...

journal_title：Diabetes

authors： Hui H,Khoury N,Zhao X,Balkir L,D'Amico E,Bullotta A,Nguyen ED,Gambotto A,Perfetti R

更新日期：2005-02-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...

journal_title：Diabetes

authors： Lovis P,Roggli E,Laybutt DR,Gattesco S,Yang JY,Widmann C,Abderrahmani A,Regazzi R

更新日期：2008-10-01 00:00:00

abstract：:Selective peroxisome proliferator-activated receptor (PPAR) gamma modulation is a new pharmacological approach that, based on selective receptor-cofactor interactions and target gene regulation, should result in potent insulin sensitization in the absence of PPARgamma-mediated adverse effects. Here, we characterize tw...

journal_title：Diabetes

authors： Schupp M,Clemenz M,Gineste R,Witt H,Janke J,Helleboid S,Hennuyer N,Ruiz P,Unger T,Staels B,Kintscher U

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00