Abstract:
:We have recently demonstrated that the exposure to hyperglycemia in utero impairs nephrogenesis in rat fetuses (Amri K et al., Diabetes 48:2240-2245, 1999). Diabetic pregnancy is commonly associated with alterations in the IGF system in fetal tissues. It has also been shown that both IGF-I and IGF-II are produced within developing metanephros and promote renal organogenesis. Therefore, we investigated the effect of maternal diabetes on IGFs and their receptors in developing fetal rat kidney. Diabetes was induced in pregnant rats by a single injection of streptozotocin on day 0 of gestation. We measured the amounts of IGF and their receptors, both proteins and mRNAs, in the metanephroi of fetuses issued from diabetic subjects and in age-matched fetuses from control subjects (14-20 days of gestation). IGF-II was produced throughout fetal nephrogenesis, whereas IGF-I protein was not detected, suggesting a critical role of IGF-II in kidney development. Fetal exposure to maternal diabetes caused no change in IGF production in the early stages of nephrogenesis. Similarly, the amounts of IGF-I receptor and insulin receptor were not altered. By contrast, there was an increase in production of IGF-II/mannose-6-phosphate receptor throughout nephrogenesis. Because this receptor plays an essential role in regulating the action of IGF-II, the altered nephrogenesis in fetuses exposed to maternal diabetes may be linked to a decrease in IGF-II bioavailability.
journal_name
Diabetesjournal_title
Diabetesauthors
Amri K,Freund N,Duong Van Huyen JP,Merlet-Bénichou C,Lelièvre-Pégorier Mdoi
10.2337/diabetes.50.5.1069subject
Has Abstractpub_date
2001-05-01 00:00:00pages
1069-75issue
5eissn
0012-1797issn
1939-327Xjournal_volume
50pub_type
杂志文章相关文献
DIABETES文献大全abstract::Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endoge...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0684
更新日期:2013-02-01 00:00:00
abstract::Enhancement of arachidonic acid metabolism results in increased insulin secretion. To determine which pathways of arachidonic acid metabolism were involved in this stimulation, we studied the effects of various inhibitors of arachidonate metabolism on arginine-induced insulin and glucagon secretion in the isolated, pe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.10.929
更新日期:1984-10-01 00:00:00
abstract::There is evidence from animal models of obesity and type 2 diabetes that increased parasympathetic vagal input to the pancreas contributes to hyperinsulinemia. Compared with Caucasians, Pima Indians have a high risk of type 2 diabetes and exhibit marked hyperinsulinemia and elevated plasma levels of pancreatic polypep...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.3.663
更新日期:2004-03-01 00:00:00
abstract::Accumulation of triosephosphates arising from high cytosolic glucose concentrations in hyperglycemia is the trigger for biochemical dysfunction leading to the development of diabetic nephropathy-a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. Here we report that s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.8.2110
更新日期:2003-08-01 00:00:00
abstract::Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.38.12.1512
更新日期:1989-12-01 00:00:00
abstract::Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects on total blood flow, could be an important variable contributing to insulin's metabolic action. We hypothesized that modest, ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.12.2682
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-0137
更新日期:2008-06-01 00:00:00
abstract::Studies were conducted to explore altered substrate utilization and metabolism in GLUT4 null mice. Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative pha...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.4.935
更新日期:2005-04-01 00:00:00
abstract::RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.2.121
更新日期:1985-02-01 00:00:00
abstract::The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet neogenesis and differentiation of i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.7.1732
更新日期:2003-07-01 00:00:00
abstract::Type 1 diabetes appears to progress not as an uncontrolled autoimmune attack on the pancreatic islet beta-cells, but rather in a highly regulated manner. Leukocytic infiltration of the pancreatic islets by autoimmune cells, or insulitis, can persist for long periods of time before the terminal destruction of beta-cell...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.9.2310
更新日期:2004-09-01 00:00:00
abstract::Exciting new findings have been reported in the past few years that indicate that islets can be transplanted successfully across major histocompatibility barriers without the continuous use of immunosuppressive agents by techniques designed to eliminate passenger leukocytes. In vitro culture of donor islets either at ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.31.4.s11
更新日期:1982-08-01 00:00:00
abstract::It is accepted for insulin-secreting cells in culture that the closure of ATP-sensitive K+ channels causes the glucose-dependent depolarization of pancreatic beta-cells seen at subthreshold levels (less than 100 mg/dl) of glucose. The question remains for the more thoroughly studied beta-cells in freshly dissected int...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.4.416
更新日期:1989-04-01 00:00:00
abstract::Activation of the receptor for advanced glycation end products (RAGE) reportedly triggers a variety of proinflammatory responses. However, our previous work revealed that RAGE-binding AGEs free of endotoxin were incapable of inducing vascular cell adhesion molecule-1 (VCAM-1) or tumor necrosis factor-alpha (TNF-alpha)...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.3.743
更新日期:2004-03-01 00:00:00
abstract::Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1863
更新日期:2001-08-01 00:00:00
abstract::Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.3.811
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown. Here, we describe the effect of PIKE deletion in mice and explore the role of PIKE-A in o...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1404
更新日期:2010-04-01 00:00:00
abstract::Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0359
更新日期:2007-02-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow-derived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment an...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1068
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that adrenergic activation, cholinergic activation, or both, mediate the effect of recent antecedent hypoglycemia to reduce the sympathoadrenal response to subsequent hypoglycemia, the key feature of hypoglycemia-associated autonomic failure in diabetes, in humans. RESEARCH DESIGN AN...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1374
更新日期:2011-02-01 00:00:00
abstract::Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-1174
更新日期:2020-09-01 00:00:00
abstract::In this study, we examined whether adenoviral-mediated glycerol kinase (AdV-CMV-GlyK) expression in isolated rat pancreatic islets could introduce glycerol-induced proinsulin biosynthesis. In AdV-CMV-GlyK-infected islets, specific glycerol-induced proinsulin biosynthesis translation and insulin secretion were observed...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1791
更新日期:2001-08-01 00:00:00
abstract::Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have unclear genetic defects, hampering our understanding of the development of the disease and preventing pathogenesis-oriented treatment. We used whole-genome sequencing with linkage analysis to study a consanguineous family with ea...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1784
更新日期:2014-10-01 00:00:00
abstract::We evaluated the production of antibodies against insulin in a genetically well-defined population. In the first study, 124 young patients with type I diabetes for longer than 6 mo were included. Anti-insulin antibodies were detected by polyethyleneglycol (PEG) precipitation after incubation of acidified, charcoal-str...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.6.634
更新日期:1986-06-01 00:00:00
abstract::We used hepatic balance and tracer ([3H]glucose) techniques to examine the impact of "breakfast" on hepatic glucose metabolism later in the same day. From 0-240 min, 2 groups of conscious dogs (n = 9 dogs/group) received a duodenal infusion of glucose (GLC) or saline (SAL), then were fasted from 240-360 min. Three dog...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1308
更新日期:2017-05-01 00:00:00
abstract::Human fetal pancreas has been obtained after the therapeutic termination of pregnancy with prostaglandin F2 alpha. Pancreatic explants were studied in a perifusion system and maintained in organ culture for up to 3 wk. Insulin biosynthesis was stimulated by glucose; however, the incorporation of 3H-L-leucine into proi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.1.s57
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-1528
更新日期:2009-09-01 00:00:00
abstract::Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.12.1402
更新日期:1994-12-01 00:00:00
abstract::We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1949
更新日期:2001-08-01 00:00:00
abstract::Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that Ig-GAD2, carrying GAD 206-220 peptide, induced in hyperglycemic mice im...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1281
更新日期:2013-08-01 00:00:00