Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise.

abstract：:Patients with diabetes are at an increased risk for developing corneal disorders, often as a result of surgical and nonsurgical trauma. This study investigated whether intensive treatment of diabetes with the goal of maintaining blood glucose concentrations close to the normal range could ameliorate the delayed cornea...

journal_title：Diabetes

authors： Zagon IS,Sassani JW,McLaughlin PJ

更新日期：2006-04-01 00:00:00

abstract：:Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that Ig-GAD2, carrying GAD 206-220 peptide, induced in hyperglycemic mice im...

journal_title：Diabetes

authors： Wan X,Guloglu FB,Vanmorlan AM,Rowland LM,Zaghouani S,Cascio JA,Dhakal M,Hoeman CM,Zaghouani H

更新日期：2013-08-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic models provide conflicting evidence as to whether VEGF prevents or ac...

journal_title：Diabetes

authors： Wu LE,Meoli CC,Mangiafico SP,Fazakerley DJ,Cogger VC,Mohamad M,Pant H,Kang MJ,Powter E,Burchfield JG,Xirouchaki CE,Mikolaizak AS,Stöckli J,Kolumam G,van Bruggen N,Gamble JR,Le Couteur DG,Cooney GJ,Andrikopoulos S,Ja

更新日期：2014-08-01 00:00:00

abstract：:Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this "glucose effectiveness" is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous system have been shown to regulate EGP in humans and rodents. We examined the ...

journal_title：Diabetes

authors： Carey M,Lontchi-Yimagou E,Mitchell W,Reda S,Zhang K,Kehlenbrink S,Koppaka S,Maginley SR,Aleksic S,Bhansali S,Huffman DM,Hawkins M

更新日期：2020-06-01 00:00:00

abstract：:Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro,...

journal_title：Diabetes

authors： Serup AK,Alsted TJ,Jordy AB,Schjerling P,Holm C,Kiens B

更新日期：2016-10-01 00:00:00

abstract：:Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+...

journal_title：Diabetes

authors： Nunemaker CS,Zhang M,Wasserman DH,McGuinness OP,Powers AC,Bertram R,Sherman A,Satin LS

更新日期：2005-12-01 00:00:00

abstract：:Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control m...

journal_title：Diabetes

authors： Fiaschi-Taesch NM,Kleinberger JW,Salim FG,Troxell R,Wills R,Tanwir M,Casinelli G,Cox AE,Takane KK,Scott DK,Stewart AF

更新日期：2013-07-01 00:00:00

abstract：:Elevated urinary albumin excretion (UAE) is a predictor of the development of nephropathy and cardiovascular mortality. To study whether genetic factors may determine UAE, we examined familial aggregation of UAE in 96 large multigenerational pedigrees ascertained for type 2 diabetes. A total of 1,269 subjects had UAE ...

journal_title：Diabetes

authors： Fogarty DG,Hanna LS,Wantman M,Warram JH,Krolewski AS,Rich SS

更新日期：2000-06-01 00:00:00

abstract：:Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in human liver would ...

journal_title：Diabetes

authors： Valenti L,Mendoza RM,Rametta R,Maggioni M,Kitajewski C,Shawber CJ,Pajvani UB

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

journal_title：Diabetes

authors： Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

更新日期：2010-04-01 00:00:00

abstract：:Exosomes are important for intercellular communication, but the role of exosomes in the communication between adipose tissue (AT) and the liver remains unknown. The aim of this study is to determine the contribution of AT-derived exosomes in nonalcoholic fatty liver disease (NAFLD). Exosome components, liver fat conte...

journal_title：Diabetes

authors： Yan C,Tian X,Li J,Liu D,Ye D,Xie Z,Han Y,Zou MH

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed further insight into ...

journal_title：Diabetes

authors： Fukuda A,Kawaguchi Y,Furuyama K,Kodama S,Horiguchi M,Kuhara T,Kawaguchi M,Terao M,Doi R,Wright CV,Hoshino M,Chiba T,Uemoto S

更新日期：2008-09-01 00:00:00

abstract：:Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-alpha expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-alpha in one of these models imp...

journal_title：Diabetes

authors： Hotamisligil GS,Spiegelman BM

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Rosiglitazone (RSG) is an insulin-sensitizing drug used to treat type 2 diabetes mellitus. The A Diabetes Outcome Progression Trial (ADOPT) shows that women taking RSG experienced more fractures than patients taking other type 2 diabetes drugs. These were not osteoporotic vertebral fractures but, rather, occu...

journal_title：Diabetes

authors： Sardone LD,Renlund R,Willett TL,Fantus IG,Grynpas MD

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the ...

journal_title：Diabetes

authors： Youn BS,Klöting N,Kratzsch J,Lee N,Park JW,Song ES,Ruschke K,Oberbach A,Fasshauer M,Stumvoll M,Blüher M

更新日期：2008-02-01 00:00:00

abstract：:To determine the role of prolactin in increasing junctional communication among islet beta-cells, we studied dye coupling in pancreatic islets exposed to elevated levels of prolactin in vivo and in vitro. Islets were isolated from rats immediately after lactation or from rats bearing mammosomatotropic tumors (MtTW15),...

journal_title：Diabetes

authors： Michaels RL,Sorenson RL,Parsons JA,Sheridan JD

更新日期：1987-10-01 00:00:00

abstract：:The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet neogenesis and differentiation of i...

journal_title：Diabetes

authors： Noguchi H,Kaneto H,Weir GC,Bonner-Weir S

更新日期：2003-07-01 00:00:00

abstract：:A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) is now at global pandemic levels causing significant morbidity and mortality. Patients with diabetes are particularly vulnerable and more likely to get severe complications when infected with this vi...

journal_title：Diabetes

authors： Gianchandani R,Esfandiari NH,Ang L,Iyengar J,Knotts S,Choksi P,Pop-Busui R

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:We monitored autoantibodies and autoreactive T-cells (using tetramers) and performed biopsy. The function of auto...

journal_title：Diabetes

authors： Vendrame F,Pileggi A,Laughlin E,Allende G,Martin-Pagola A,Molano RD,Diamantopoulos S,Standifer N,Geubtner K,Falk BA,Ichii H,Takahashi H,Snowhite I,Chen Z,Mendez A,Chen L,Sageshima J,Ruiz P,Ciancio G,Ricordi C,Reij

更新日期：2010-04-01 00:00:00

abstract：:Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin receptor (LEPR) mutation (designated Lepr(db-5J)) producing juvenile obesity, hyperglycemia, hyperinsulinemia, and hyperleptinemia. This early type 2 diabetes syndrome suppressed intra-islet insulitis and permitted spontane...

journal_title：Diabetes

authors： Lee CH,Chen YG,Chen J,Reifsnyder PC,Serreze DV,Clare-Salzler M,Rodriguez M,Wasserfall C,Atkinson MA,Leiter EH

更新日期：2006-01-01 00:00:00

abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

journal_title：Diabetes

authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

更新日期：2001-02-01 00:00:00

abstract：:To determine the contribution of the rate of glucose recycling via the Cori cycle (glucose----3-carbon compounds----glucose) to the higher rate of endogenous glucose production (EGPR) in subjects with non-insulin-dependent diabetes mellitus (NIDDM), we studied eight obese, weight-stabilized diabetic Pima Indians befor...

journal_title：Diabetes

authors： Zawadzki JK,Wolfe RR,Mott DM,Lillioja S,Howard BV,Bogardus C

更新日期：1988-02-01 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：:Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored t...

journal_title：Diabetes

authors： Desai UJ,Slosberg ED,Boettcher BR,Caplan SL,Fanelli B,Stephan Z,Gunther VJ,Kaleko M,Connelly S

更新日期：2001-10-01 00:00:00

abstract：:In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...

journal_title：Diabetes

authors： Harada K,Shimano H,Ishibashi S,Yamada N

更新日期：1996-07-01 00:00:00

abstract：:The beta-3 adrenergic receptor (ADRB3) has been implicated as a regulator of energy expenditure, and a polymorphism in codon 64 of this gene (Trp64Arg) has been associated in some studies with obesity and insulin resistance. However, many studies have failed to detect an effect of this variant, and the importance of t...

journal_title：Diabetes

authors： Mitchell BD,Cole SA,Comuzzie AG,Almasy L,Blangero J,MacCluer JW,Hixson JE

更新日期：1999-09-01 00:00:00

abstract：:The past several years have seen an explosive increase in our understanding of the transcriptional basis of adipose cell differentiation. In particular, a key role has been illustrated for PPAR-gamma, a member of the nuclear hormone receptor superfamily. PPAR-gamma has also been recently identified as the major functi...

journal_title：Diabetes

authors： Spiegelman BM

更新日期：1998-04-01 00:00:00

abstract：:Phorbol esters translocatively activate and subsequently downregulate protein kinase C and insulin-stimulated glucose uptake in rat adipocytes. This study examined the possibility that other translocative activators of protein kinase C in rat adipocytes, e.g., insulin and glucose, provoke similar downregulating effect...

journal_title：Diabetes

authors： Ishizuka T,Cooper DR,Arnold T,Hernandez H,Farese RV

更新日期：1991-10-01 00:00:00

abstract：:The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...

journal_title：Diabetes

authors： Norfleet WT,Pagliara AS,Haymond MW,Matschinsky F

更新日期：1975-11-01 00:00:00

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00