Control of blood glucose in experimental diabetes by means of a totally implantable insulin infusion device.

Abstract:

:Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by the addition of predetermined pulses of insulin at higher flow rates than the basal flow rate, accomplished by use of a transcutaneously activated valve mechanism attached to the implanted infusion pump. We conclude that near-normal blood glucose concentrations can be maintained throughout the day in the dog by these means and that similar approaches, using implantable infusion pumps, in man may lead to better long-term control of diabetes than is currently available.

journal_name

Diabetes

journal_title

Diabetes

authors

Blackshear PJ,Rohde TD,Grotting JC,Dorman FD,Perkins PR,Varco RL,Buchwald H

doi

10.2337/diab.28.7.634

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

634-9

issue

7

eissn

0012-1797

issn

1939-327X

journal_volume

28

pub_type

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