Abstract:
:To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
journal_name
Diabetesjournal_title
Diabetesauthors
Ko BC,Lam KS,Wat NM,Chung SSdoi
10.2337/diabetes.44.7.727subject
Has Abstractpub_date
1995-07-01 00:00:00pages
727-32issue
7eissn
0012-1797issn
1939-327Xjournal_volume
44pub_type
杂志文章相关文献
DIABETES文献大全abstract::The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.47.2.244
更新日期:1998-02-01 00:00:00
abstract::The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreas development and in beta-cell function. Upstream sequences of the gene up to about -6 kb show islet-specific activity in transgenic mice. Attempts to identify functional regulatory elements involved in th...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.2007.s320
更新日期:2002-12-01 00:00:00
abstract::Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.2.301
更新日期:2001-02-01 00:00:00
abstract::Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1178
更新日期:2019-08-01 00:00:00
abstract::Tolbutamide (1 g/kg body wt) was administered to male rats for 3 days to determine the effects of this pretreatment on subsequent insulin biosynthesis and compartmental storage characteristics of freshly isolated islets. Islets were isolated 16 h after the last tolbutamide administration, at a time when fed plasma glu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.1.6
更新日期:1986-01-01 00:00:00
abstract::With the aim of investigating glucose-mediated glucose disposal (glucose effectiveness [GE]) in 15 (3 female and 12 male subjects) insulin-resistant normoglycemic relatives of patients with type 2 diabetes (DM2), and 15 age-, sex-, and BMI-matched control subjects without a family history of DM2, we performed 2 studie...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.7.1209
更新日期:2000-07-01 00:00:00
abstract::Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.1.160
更新日期:2004-01-01 00:00:00
abstract::Widely held theories of the pathogenesis of obesity-associated NIDDM have implicated apparently incompatible events as seminal: 1) insulin resistance in muscle, 2) abnormal secretion of insulin, and 3) increases in intra-abdominal fat. Altered circulating or tissue lipids are characteristic features of obesity and NID...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.45.3.273
更新日期:1996-03-01 00:00:00
abstract::Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma MGO levels are associated with incident CVD in people with type 1 diabetes is unknown. We included 159 individuals with pers...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1578
更新日期:2017-08-01 00:00:00
abstract::Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In di...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.7.601
更新日期:1981-07-01 00:00:00
abstract::Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0239
更新日期:2015-12-01 00:00:00
abstract::Peptidic glucagon antagonists have been shown to lower blood glucose levels in diabetic models (1-3), but attempts to identify small molecular weight glucagon receptor-binding antagonists have met with little success. Skyrin, a fungal bisanthroquinone, exhibits functional glucagon antagonism by uncoupling the glucagon...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.12.2079
更新日期:2000-12-01 00:00:00
abstract::Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db20-0373
更新日期:2021-02-01 00:00:00
abstract::The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0441
更新日期:2018-01-01 00:00:00
abstract::Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0946
更新日期:2017-08-01 00:00:00
abstract::Diabetic hypoglycemia produces cognitive-motor slowing, which is assumed to increase risk of automobile crashes. This study investigated driving decrements during and after hypoglycemia, and the patients' awareness of driving decrements. We used a randomized, single-blind, crossover design and conducted the study at t...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.42.2.239
更新日期:1993-02-01 00:00:00
abstract::Poorly controlled insulin-dependent diabetes mellitus (IDDM) is associated with elevated basal plasma growth hormone (GH), disproportionally low insulin-like growth factor I (IGF-I) levels, and impaired somatic growth. These derangements in the GH-IGF axis imply a state of GH resistance. The mechanism of GH resistance...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.5.605
更新日期:1992-05-01 00:00:00
abstract::The effect of muscular exertion of moderate intensity on blood sugar (BS), plasma levels of growth hormone (GH), glucagon, and cortisol (F) has been studied in endocrinologically normal children with short stature and compared with children with clinical diabetes mellitus and obese children with normal and diminished ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.8.758
更新日期:1975-08-01 00:00:00
abstract::The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of r...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/db16-0796
更新日期:2017-04-01 00:00:00
abstract::beta-Cell cycle progression and proliferation are critical to maintain beta-cell mass in adult mice. Of the cell cycle inhibitors, p27Kip1 is thought to be the primary modulator of the proliferative status in most cell types. p27 plays a role in beta-cell adaptation in genetic models of insulin resistance. To study th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0861
更新日期:2006-12-01 00:00:00
abstract::Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.8.2395
更新日期:2002-08-01 00:00:00
abstract::We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1949
更新日期:2001-08-01 00:00:00
abstract::Streptozocin-induced diabetic (STZ-D) mice have reduced brain concentrations of tryptophan, a precursor substance for 5-hydroxytryptamine, and show lengthened immobility in Porsolt's swim test, a putative animal model of depression. This study investigated whether tryptophan affects behavior in Porsolt's swim test in ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1598
更新日期:1991-12-01 00:00:00
abstract::Both the coding and control regions of mitochondrial DNA (mtDNA) play roles in the generation of diabetes; however, no studies have thoroughly reported on the combined diabetogenic effects of variants in the two regions. We determined the mitochondrial haplogroup and the mtDNA sequence of the control region in 859 sub...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1369
更新日期:2012-10-01 00:00:00
abstract::Recent large-scale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict the development of NIDDM and IDDM and are associated with the risk of several degenerative diseases, such as coronary and peripheral vessel atherosclerosis, hypertension, and dyslipidemia. The reliability...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.2.242
更新日期:1996-02-01 00:00:00
abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogenous disorder characterized by defects in insulin action and secretion. This study was aimed at developing a rat model in which these pathogenic factors might be studied. Male Wistar rats were injected at 2 days of age with 45 or 30 mg/kg streptozocin (STZ) ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.2.226
更新日期:1990-02-01 00:00:00
abstract::In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.3.s129
更新日期:1996-07-01 00:00:00
abstract::Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.4.1185
更新日期:2005-04-01 00:00:00
abstract::The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior. Immunoprecipitation, immunofluorescent staining, and RT-PCR of human VSMCs showed that elevat...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.2.519
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in more detail than previously done and, for the first time, analyzed the steady-state recycling and subseq...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1578
更新日期:2008-02-01 00:00:00