Abstract:
:Extensive investigations of the solubility and fluorescence of collagen fibers in diabetes have revealed that there are significant changes in their physical properties. These changes are associated with increased cross-link formation. We used X-ray diffraction to study these changes in human extensor tendons at a molecular level in relation to both aging and diabetes. Our results indicate that diabetes induces significant alterations in the ultrastructure of collagen in the lateral packing of the molecules and the axial structure of the specimen. These changes can be induced in normal tendon by incubation in ribose and glucose-6-phosphate but are different from those associated with the normal process of aging.
journal_name
Diabetesjournal_title
Diabetesauthors
James VJ,Delbridge L,McLennan SV,Yue DKdoi
10.2337/diab.40.3.391subject
Has Abstractpub_date
1991-03-01 00:00:00pages
391-4issue
3eissn
0012-1797issn
1939-327Xjournal_volume
40pub_type
杂志文章相关文献
DIABETES文献大全abstract::On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.2007.s82
更新日期:2004-02-01 00:00:00
abstract::Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic N...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0493
更新日期:2007-01-01 00:00:00
abstract::Recent studies have identified that the activation of protein kinase C (PKC) and increased diacylglycerol (DAG) levels initiated by hyperglycemia are associated with many vascular abnormalities in retinal, renal, and cardiovascular tissues. Among the various PKC isoforms, the beta- and delta-isoforms appear to be acti...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.47.6.859
更新日期:1998-06-01 00:00:00
abstract::Diabetic nephropathy is the main cause of end-stage renal disease requiring dialysis in developed countries. In this study, we demonstrated the therapeutic effect of hepatocyte growth factor (HGF) on advanced rather than early diabetic nephropathy using a rat model of streptozotocin-induced diabetes. Early diabetic ne...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.4.1119
更新日期:2004-04-01 00:00:00
abstract::Peptide-YY (PYY) is secreted from endocrine L-cells of the gastrointestinal tract in response to caloric ingestion and may mediate postprandial satiety through the hypothalamic neuropeptide Y2 receptor (Y2R). We examined whether variants in the genes encoding PYY and Y2R might be associated with obesity-related phenot...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.9.2461
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHO...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-0144
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures. RESEARCH DESI...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0585
更新日期:2007-11-01 00:00:00
abstract::By closing ATP-sensitive K+ (K+-ATP) channels, glucose promotes depolarization-dependent Ca2+ entry and cytoplasmic free Ca2+ concentration ([Ca2+]i) rise in beta-cells. Ca2+-dependent exocytosis of insulin granules is then potentiated by a K+-ATP channel-independent action of glucose. The underlying mechanisms of thi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.11.1713
更新日期:1998-11-01 00:00:00
abstract::For the period of 1 January 1979 through 31 December 1985, an average annual incidence rate (IR) of 12.1/100,000 (95% confidence interval [10.4/100,000, 14.0/100,000]) of insulin-dependent diabetes mellitus (IDDM) was observed in Jefferson County, Alabama, among people less than 20 yr old. Hospital medical-record revi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.5.629
更新日期:1989-05-01 00:00:00
abstract::Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1039
更新日期:2007-03-01 00:00:00
abstract::Diabetes results from an inadequate mass of functional beta-cells. Such inadequacy could result from loss of beta-cells due to an immune assault or the inability to compensate for insulin resistance. Thus, mechanisms that regulate the number of beta-cells will be key to understanding both the pathogenesis of diabetes ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0249
更新日期:2006-11-01 00:00:00
abstract::Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0510
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1334
更新日期:2010-04-01 00:00:00
abstract::Previous studies have indicated that individuals with type 2 diabetes have an increased resting metabolic rate (RMR) but decreased insulin-induced thermogenesis (IIT) compared with those with normal glucose tolerance (NGT). When and by which mechanisms these abnormalities occur during the development of diabetes remai...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.8.1607
更新日期:1999-08-01 00:00:00
abstract::Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0184
更新日期:2018-11-01 00:00:00
abstract::Mitochondria are the essential eukaryotic organelles that produce most cellular energy. The energy production and supply by mitochondria appear closely associated with the continuous shape change of mitochondria mediated by fission and fusion, as evidenced not only by the hereditary diseases caused by mutations in fis...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1640
更新日期:2012-08-01 00:00:00
abstract::Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0281
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS:In Sweden, all incident ca...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1744
更新日期:2010-07-01 00:00:00
abstract::Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin-resistant, and predisposed to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then it has become in...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.47.5.699
更新日期:1998-05-01 00:00:00
abstract::Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases, but this is impaired in diabetes. We hypothesized that breaking advanced glycation end product (AGE) cross-links could improve remodeling in mesenteric resistance arteries in Zucker diabetic fatty (ZDF) rats compar...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0750
更新日期:2012-06-01 00:00:00
abstract::Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1281
更新日期:2018-09-01 00:00:00
abstract::To investigate the short-term effects of didecanoyl-L-alpha-phosphatidylcholine on the nasal mucosa and the mechanism by which didecanoyl-L-alpha-phosphatidylcholine enhances the nasal absorption of insulin, an in vitro model was developed. The mucosa from the posterior part of the rabbit nasal septum was mounted in a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.7.1032
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0031
更新日期:2009-09-01 00:00:00
abstract::Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0061
更新日期:2020-02-01 00:00:00
abstract::The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.12.1045
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:Since vascular dysfunction is a main trait of obese subjects, in the present study we evaluated the vascular impact of resistin, a recently discovered hormone markedly increased in obesity. RESEARCH DESIGN AND METHODS:We performed our analysis on aortic and mesenteric segments from young and old C57BL/6 mice...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0557
更新日期:2008-03-01 00:00:00
abstract::A significant increase in CO2 production, reflecting carbohydrate oxidation and/or fat synthesis, is observed in normal subjects after the ingestion of glucose. The anatomic site(s) of this CO2 production has not yet been localized, although liver and muscle are logical considerations. To assess the contribution of sk...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.10.960
更新日期:1985-10-01 00:00:00
abstract::A number of patients with type 2 diabetes are GAD antibody positive. A Diabetes Outcome Progression Trial (ADOPT) is a randomized, double-blind clinical trial in recently diagnosed drug-naive patients with type 2 diabetes that allows for the evaluation of GAD positivity in the context of anthropometric and biochemical...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diabetes.53.12.3193
更新日期:2004-12-01 00:00:00
abstract::Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.5.876
更新日期:2000-05-01 00:00:00
abstract::Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In prelim...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.47.1.93
更新日期:1998-01-01 00:00:00