A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians.

abstract：:Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...

journal_title：Diabetes

authors： Henry RR,Abrams L,Nikoulina S,Ciaraldi TP

更新日期：1995-08-01 00:00:00

abstract：:This article seeks to determine whether factors related to autoimmunity risk remain significant after the initiation of two or more diabetes-related autoantibodies and continue to contribute to type 1 diabetes (T1D) risk among autoantibody-positive children in The Environmental Determinants of Diabetes in the Young (T...

journal_title：Diabetes

authors： Krischer JP,Liu X,Lernmark Å,Hagopian WA,Rewers MJ,She JX,Toppari J,Ziegler AG,Akolkar B,TEDDY Study Group.

更新日期：2017-12-01 00:00:00

abstract：:Because high D-glucose significantly stimulates endothelial cell death, we examined the molecular mechanisms of high D-glucose-induced endothelial apoptosis. Treatment of human aortic endothelial cells with high D-glucose (25 mmol/l), but not mannitol and L-glucose, resulted in a significant decrease in cell number an...

journal_title：Diabetes

authors： Nakagami H,Morishita R,Yamamoto K,Yoshimura SI,Taniyama Y,Aoki M,Matsubara H,Kim S,Kaneda Y,Ogihara T

更新日期：2001-06-01 00:00:00

abstract：:OKT3 has emerged as a highly effective antirejection therapy, but its efficacy in pancreas transplantation remains to be determined. During a 26-mo period, 46 vascularized pancreas transplants were performed with pancreaticoduodenocystostomy. Twenty-one patients (45.7%) were treated with OKT3. Indications for OKT3 use...

journal_title：Diabetes

authors： Stratta RJ,Sollinger HW,D'Alessandro AM,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will...

journal_title：Diabetes

authors：

更新日期：1995-11-01 00:00:00

abstract：:Neonatal rats injected with streptozocin (STZ, 100 mg/kg) at birth exhibited an acute diabetes followed by a spontaneous remission. We have previously shown that this recovery from neonatal diabetes is due to B-cell regeneration and reaccumulation of pancreatic insulin stores starting from 3 to 5 days after birth. The...

journal_title：Diabetes

authors： Portha B,Kergoat M

更新日期：1985-06-01 00:00:00

abstract：:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...

journal_title：Diabetes

authors： Virji MA,Steffes MW,Estensen RD

更新日期：1984-02-01 00:00:00

abstract：:To explain the contradictory data on the secretion of prostacyclin (PGI2) in clinical and experimental diabetes, we have investigated the effect of each of the major metabolic abnormalities in uncontrolled diabetes on vascular PGI2 synthesis. An increase in fatty acid concentrations caused a dose-dependent inhibition ...

journal_title：Diabetes

authors： Jeremy JY,Mikhailidis DP,Dandona P

更新日期：1983-03-01 00:00:00

abstract：:Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...

journal_title：Diabetes

authors： Friedman JE

更新日期：2018-11-01 00:00:00

abstract：:Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-A...

journal_title：Diabetes

authors： Peppa M,Brem H,Ehrlich P,Zhang JG,Cai W,Li Z,Croitoru A,Thung S,Vlassara H

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

journal_title：Diabetes

authors： Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

更新日期：2010-08-01 00:00:00

abstract：:Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...

journal_title：Diabetes

authors： Oh BJ,Jin SM,Hwang Y,Choi JM,Lee HS,Kim G,Kim G,Park HJ,Kim P,Kim SJ,Kim JH

更新日期：2018-03-01 00:00:00

abstract：:The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...

journal_title：Diabetes

authors： Bingham EM,Hopkins D,Smith D,Pernet A,Hallett W,Reed L,Marsden PK,Amiel SA

更新日期：2002-12-01 00:00:00

abstract：:Nonketotic, genetically diabetic Cinese hamsters show subnormal pancreatic insulin release and impaired suppression of glucagon in response to glucose. To study the pancreatic effects of other agents, dynamic insulin and glucagon release was measured from the in vitro perfused pancreases of normal and diabetic Chinese...

journal_title：Diabetes

authors： Frankel BJ,Gerich JE,Fanska RE,Gerritsen GC,Grodsky GM

更新日期：1975-03-01 00:00:00

abstract：OBJECTIVE:Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. RESEARCH DESI...

journal_title：Diabetes

authors： Rutanen J,Yaluri N,Modi S,Pihlajamäki J,Vänttinen M,Itkonen P,Kainulainen S,Yamamoto H,Lagouge M,Sinclair DA,Elliott P,Westphal C,Auwerx J,Laakso M

更新日期：2010-04-01 00:00:00

abstract：:Studies in rodents suggest that insulin controls hepatic glucose metabolism through brain-liver crosstalk, but human studies using intranasal insulin to mimic central insulin delivery have provided conflicting results. In this randomized controlled crossover trial, we investigated the effects of intranasal insulin on ...

journal_title：Diabetes

authors： Gancheva S,Koliaki C,Bierwagen A,Nowotny P,Heni M,Fritsche A,Häring HU,Szendroedi J,Roden M

更新日期：2015-06-01 00:00:00

abstract：:Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is well characterized. It involves the following sequence of events: entry of glucose by facilitated diffusion, metabolism of glucose by oxidative glycolysis, rise in the ATP-to-ADP ratio, closure...

journal_title：Diabetes

authors： Henquin JC

更新日期：2000-11-01 00:00:00

abstract：:The peripheral nerve disorders associated with diabetes are complex and probably involve a variety of causative mechanisms. This may give rise to difficulty in the classification of individual cases. A broad separation into rapidly reversible or more persistent phenomena is helpful. The former, which can be categorize...

journal_title：Diabetes

authors： Thomas PK

更新日期：1997-09-01 00:00:00

abstract：:In this study, we examined whether adenoviral-mediated glycerol kinase (AdV-CMV-GlyK) expression in isolated rat pancreatic islets could introduce glycerol-induced proinsulin biosynthesis. In AdV-CMV-GlyK-infected islets, specific glycerol-induced proinsulin biosynthesis translation and insulin secretion were observed...

journal_title：Diabetes

authors： Skelly RH,Wicksteed B,Antinozzi PA,Rhodes CJ

更新日期：2001-08-01 00:00:00

abstract：:Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD i...

journal_title：Diabetes

authors： Marshall AG,Lee-Kubli C,Azmi S,Zhang M,Ferdousi M,Mixcoatl-Zecuatl T,Petropoulos IN,Ponirakis G,Fineman MS,Fadavi H,Frizzi K,Tavakoli M,Jeziorska M,Jolivalt CG,Boulton AJM,Efron N,Calcutt NA,Malik RA

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Insulin resistance in skeletal muscle is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). However, the molecular mechanisms underlying skeletal muscle insulin resistance and the insulin-sensitizing effect of thiazolidinediones in PCOS in vivo are less well characterized....

journal_title：Diabetes

authors： Højlund K,Glintborg D,Andersen NR,Birk JB,Treebak JT,Frøsig C,Beck-Nielsen H,Wojtaszewski JF

更新日期：2008-02-01 00:00:00

abstract：:Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro,...

journal_title：Diabetes

authors： Serup AK,Alsted TJ,Jordy AB,Schjerling P,Holm C,Kiens B

更新日期：2016-10-01 00:00:00

abstract：:Myo-Inositol depletion as a result of hyperglycemia is considered one of the leading contributors to chronic diabetic complications. We investigated the possible mechanisms through which elevated extracellular glucose levels affect the loss of intracellular myo-inositol in rat lens. Short-term incubation (up to 4 h) i...

journal_title：Diabetes

authors： Mistry KP,Beyer-Mears A,Diecke FP

更新日期：1993-12-01 00:00:00

abstract：:Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endog...

journal_title：Diabetes

authors： Dhawan S,Dirice E,Kulkarni RN,Bhushan A

更新日期：2016-05-01 00:00:00

abstract：:A new approach has been developed to examine insulin sensitivity and resistance in vivo in man. In it, tracer methods are used, which permit the assessment of nonsteady state glucose kinetics by a method that is noninvasive and does not use pharmacologic agents. Graded doses of glucagon, infused intravenously, are use...

journal_title：Diabetes

authors： Vranic M,Morita S,Steiner G

更新日期：1980-03-01 00:00:00

abstract：:Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

journal_title：Diabetes

authors： Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

更新日期：2005-04-01 00:00:00

abstract：:A chronic diabetic state was produced in Macaca fuscatus , and these diabetic monkeys were kept without insulin treatment for up to 25 mo. The metabolic derangements were characterized by hyperglycemia, insulinopenia, hyperglucagonemia, ketonemia, and hyperlipidemia. Significant thickening of the capillary basement me...

journal_title：Diabetes

authors： Yasuda H,Harano Y,Kosugi K,Nakano T,Suzuki M,Tsuruoka Y,Taniguchi Y,Nishimori T,Kikkawa R,Shigeta Y

更新日期：1984-05-01 00:00:00

abstract：:A simple, direct assay for T-lymphocyte reactivity to islet antigen(s) in human insulin-dependent diabetes mellitus (IDDM) should facilitate preclinical diagnosis and the evaluation of intervention therapy to avert autoimmune-mediated beta-cell destruction. In subjects with preclinical or clinical IDDM, we measured th...

journal_title：Diabetes

authors： Harrison LC,De Aizpurua H,Loudovaris T,Campbell IL,Cebon JS,Tait BD,Colman PG

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:The uptake of 2-deoxy-D-[1-14C]-glucose, in the presence and absence of insulin, was measured in adipocytes from normal and streptozotocin-diabetic animals, over a wide temperature range (25-45 degrees C). Optimum temperatures for uptake in the presence of maximally stimulating insulin concentrations occurred near phy...

journal_title：Diabetes

authors： Sauerheber RD,Kuhn CE,Hyslop PA

更新日期：1984-03-01 00:00:00