Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia.

abstract：:Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity....

journal_title：Diabetes

authors： Hivert MF,Christophi CA,Franks PW,Jablonski KA,Ehrmann DA,Kahn SE,Horton ES,Pollin TI,Mather KJ,Perreault L,Barrett-Connor E,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

更新日期：2016-02-01 00:00:00

abstract：:Decreased retinal blood flow has been measured in streptozotocin (STZ)-induced diabetes of 1 week's duration, and primary insulin intervention was effective in maintaining normal retinal blood flow in diabetic rats. Retinal blood-flow abnormalities precede clinical diabetic retinopathy in both diabetic animals and pat...

journal_title：Diabetes

authors： Higashi S,Clermont AC,Dhir V,Bursell SE

更新日期：1998-04-01 00:00:00

abstract：:Both pancreatic volume reduction and lipomatosis have been observed in subjects with diabetes. The underlying molecular and pathological mechanisms are, however, poorly known, and it has been speculated that both features are secondary to diabetes. We have recently described pancreatic atrophy and lipomatosis in diabe...

journal_title：Diabetes

authors： Raeder H,Haldorsen IS,Ersland L,Grüner R,Taxt T,Søvik O,Molven A,Njølstad PR

更新日期：2007-02-01 00:00:00

abstract：:Adiponectin, one of the most abundant gene transcript proteins in human fat cells, has been shown to improve insulin action and is also suggested to exert antiatherogenic effects. We measured circulating adiponectin levels and risk factors for atherosclerosis in 45 healthy first-degree relatives of type 2 diabetic sub...

journal_title：Diabetes

authors： Pellmé F,Smith U,Funahashi T,Matsuzawa Y,Brekke H,Wiklund O,Taskinen MR,Jansson PA

更新日期：2003-05-01 00:00:00

abstract：:We tested 32 routine clinical parameters for their ability to discriminate between a high risk and a low risk of non-insulin-dependent diabetes mellitus (NIDDM) within 5-7 years after pregnancies complicated by gestational diabetes mellitus (GDM). Latino women (n = 671) with GDM who did not have diabetes 4-16 weeks af...

journal_title：Diabetes

authors： Kjos SL,Peters RK,Xiang A,Henry OA,Montoro M,Buchanan TA

更新日期：1995-05-01 00:00:00

abstract：:This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enr...

journal_title：Diabetes

authors： Santos AR,Ribeiro L,Bandello F,Lattanzio R,Egan C,Frydkjaer-Olsen U,García-Arumí J,Gibson J,Grauslund J,Harding SP,Lang GE,Massin P,Midena E,Scanlon P,Aldington SJ,Simão S,Schwartz C,Ponsati B,Porta M,Costa MÂ,Her

更新日期：2017-09-01 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of ...

journal_title：Diabetes

authors： Berglund LM,Lyssenko V,Ladenvall C,Kotova O,Edsfeldt A,Pilgaard K,Alkayyali S,Brøns C,Forsblom C,Jonsson A,Zetterqvist AV,Nitulescu M,McDavitt CR,Dunér P,Stancáková A,Kuusisto J,Ahlqvist E,Lajer M,Tarnow L,Madsbad S

更新日期：2016-01-01 00:00:00

abstract：:To determine the role of prolactin in increasing junctional communication among islet beta-cells, we studied dye coupling in pancreatic islets exposed to elevated levels of prolactin in vivo and in vitro. Islets were isolated from rats immediately after lactation or from rats bearing mammosomatotropic tumors (MtTW15),...

journal_title：Diabetes

authors： Michaels RL,Sorenson RL,Parsons JA,Sheridan JD

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Human islet amyloid polypeptide (hIAPP) aggregation plays a major role in the development of islet amyloidosis in type 2 diabetes. It is known that extracellular hIAPP oligomers are toxic to pancreatic beta-cells and associated with apoptosis. We therefore investigated the molecular mechanism by which extrace...

journal_title：Diabetes

authors： Casas S,Gomis R,Gribble FM,Altirriba J,Knuutila S,Novials A

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:The implication of innate immunity in type 1 diabetes development has long been proposed. High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was recently recognized to be a potent innate inflammatory mediator when released extracellularly. We sought to test the hypothesis that...

journal_title：Diabetes

authors： Han J,Zhong J,Wei W,Wang Y,Huang Y,Yang P,Purohit S,Dong Z,Wang MH,She JX,Gong F,Stern DM,Wang CY

更新日期：2008-08-01 00:00:00

abstract：:NO has been identified recently as the prime islet-toxic product of inflammatory macrophages. The adverse effects of IL-1 on isolated islets also have been reported to involve NO. We now show that exposure of an islet cell suspension to the NO donor nitroprusside or to activated macrophages leads to DNA strand breaks....

journal_title：Diabetes

authors： Fehsel K,Jalowy A,Qi S,Burkart V,Hartmann B,Kolb H

更新日期：1993-03-01 00:00:00

abstract：:The influence of insulin on the intracellular free sodium and potassium ion concentrations ([Na+]i, [K+]i) and resting membrane potential of rat epididymal adipocytes was examined to determine its potential for mediating insulin's action on other cellular processes. Direct intracellular measurements of [Na+]i, [K+]i, ...

journal_title：Diabetes

authors： Stark RJ,Read PD,O'Doherty J

更新日期：1980-12-01 00:00:00

abstract：:The IGF system is increasingly implicated in the development of cardiovascular disease. The effects of circulating IGFs on the vasculature are largely modulated by IGFBPs, which control their access to cell-surface IGF receptors. IGFBP-1 has been proposed as the acute regulator of IGF bioavailability because of its me...

journal_title：Diabetes

authors： Heald AH,Siddals KW,Fraser W,Taylor W,Kaushal K,Morris J,Young RJ,White A,Gibson JM

更新日期：2002-08-01 00:00:00

abstract：:Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes. Using pharmacologic agents, we previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA t...

journal_title：Diabetes

authors： Le Foll C,Dunn-Meynell A,Musatov S,Magnan C,Levin BE

更新日期：2013-08-01 00:00:00

abstract：:Spirometry was performed on 88 children with insulin-dependent diabetes mellitus (IDDM) and 216 healthy controls living in Sheffield. Children with IDDM had significantly lower percentage predicted forced vital capacity (FVC) than did control children or reference norms. There was no evidence that the reduced FVC was ...

journal_title：Diabetes

authors： Primhak RA,Whincup G,Tsanakas JN,Milner RD

更新日期：1987-03-01 00:00:00

abstract：:The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of beta-cell death responsible for the development of IDDM. Apoptotic cells were present within the islets of Langerhans in hematoxylin and eosin-stained sections of pancreases harvested from 3- to 18-week-old female NOD/Lt ...

journal_title：Diabetes

authors： O'Brien BA,Harmon BV,Cameron DP,Allan DJ

更新日期：1997-05-01 00:00:00

abstract：:Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+...

journal_title：Diabetes

authors： Nunemaker CS,Zhang M,Wasserman DH,McGuinness OP,Powers AC,Bertram R,Sherman A,Satin LS

更新日期：2005-12-01 00:00:00

abstract：:NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via an αβ T-cell receptor (TCR) incorporating TRAV8-1/TRAJ9 and TRBV19/T...

journal_title：Diabetes

authors： Pearson JA,Thayer TC,McLaren JE,Ladell K,De Leenheer E,Phillips A,Davies J,Kakabadse D,Miners K,Morgan P,Wen L,Price DA,Wong FS

更新日期：2016-06-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：:The effect of nonenzymatic glycosylation on the biologic function of human antithrombin III was evaluated using a chromogenic thrombin substrate assay in the presence of catalytic amounts of heparin. Experimental conditions that increased the rate of nonenzymatic protein glycosylation were associated with decreases in...

journal_title：Diabetes

authors： Brownlee M,Vlassara H,Cerami A

更新日期：1984-06-01 00:00:00

abstract：:Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...

journal_title：Diabetes

authors： van de Weijer T,Phielix E,Bilet L,Williams EG,Ropelle ER,Bierwagen A,Livingstone R,Nowotny P,Sparks LM,Paglialunga S,Szendroedi J,Havekes B,Moullan N,Pirinen E,Hwang JH,Schrauwen-Hinderling VB,Hesselink MK,Auwerx J,Ro

更新日期：2015-04-01 00:00:00

abstract：:Abnormalities of methyl-CpG binding protein 2 (Mecp2) cause neurological disorders with metabolic dysfunction; however, its role in adipose tissues remains unclear. Here, we report upregulated Mecp2 in white adipose tissues (WAT) of obese humans, as well as in obese mice and during in vitro adipogenesis. Normal chow-f...

journal_title：Diabetes

authors： Liu C,Wang J,Wei Y,Zhang W,Geng M,Yuan Y,Chen Y,Sun Y,Chen H,Zhang Y,Xiong M,Li Y,Zheng L,Huang K

更新日期：2020-01-01 00:00:00

abstract：:One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the gene encoding hepatocyte nuclear factor (HNF)-1 alpha. We generated transgenic mice expressing a naturally occurring dominant-negative form of human HNF-1 alpha (P291fsinsC) in pancreatic beta-cells. A progressive hyperglycemia ...

journal_title：Diabetes

authors： Yamagata K,Nammo T,Moriwaki M,Ihara A,Iizuka K,Yang Q,Satoh T,Li M,Uenaka R,Okita K,Iwahashi H,Zhu Q,Cao Y,Imagawa A,Tochino Y,Hanafusa T,Miyagawa J,Matsuzawa Y

更新日期：2002-01-01 00:00:00

abstract：:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

journal_title：Diabetes

authors： Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

更新日期：1983-09-01 00:00:00

abstract：:Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...

journal_title：Diabetes

authors： Young RJ,Ewing DJ,Clarke BF

更新日期：1983-02-01 00:00:00

abstract：:Diabetes diagnostic therapy and research would strongly benefit from noninvasive accurate imaging of the functional β-cells in the pancreas. Here, we developed an analysis of functional β-cell mass (BCM) by measuring manganese (Mn(2+)) uptake kinetics into glucose-stimulated β-cells by T1-weighted in vivo Mn(2+)-media...

journal_title：Diabetes

authors： Meyer A,Stolz K,Dreher W,Bergemann J,Holebasavanahalli Thimmashetty V,Lueschen N,Azizi Z,Khobragade V,Maedler K,Kuestermann E

更新日期：2015-06-01 00:00:00

abstract：:Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet amyloid when fed a breeder chow but not regular chow. Because the breeder chow contained incre...

journal_title：Diabetes

authors： Hull RL,Andrikopoulos S,Verchere CB,Vidal J,Wang F,Cnop M,Prigeon RL,Kahn SE

更新日期：2003-02-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...

journal_title：Diabetes

authors： Zhou H,Zhang T,Bogdani M,Oseid E,Parazzoli S,Vantyghem MC,Harmon J,Slucca M,Robertson RP

更新日期：2008-06-01 00:00:00