Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice.

abstract：:Postmortem studies have shown a relationship between diabetic state and atherosclerotic arterial lesions in adolescents. The aim of the present study was to determine the presence of increased subclinical atherosclerosis (measured as carotid intima-media thickness [IMT]) and its risk factors, including lipoprotein oxi...

journal_title：Diabetes

authors： Järvisalo MJ,Putto-Laurila A,Jartti L,Lehtimäki T,Solakivi T,Rönnemaa T,Raitakari OT

更新日期：2002-02-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:T-1095A and T-1095 are synthetic agents derived from phlorizin, a specific inhibitor of Na+-glucose cotransporters (SGLTs). Unlike phlorizin, T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney. Orally administe...

journal_title：Diabetes

authors： Oku A,Ueta K,Arakawa K,Ishihara T,Nawano M,Kuronuma Y,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T,Kanai Y,Endou H

更新日期：1999-09-01 00:00:00

abstract：:To evaluate possible advantages of human insulin of recombinant DNA origin (HI) in the treatment of diabetic patients, we compared cellular and humoral immunoreactivities of HI and porcine insulin (PI). Anti-insulin IgE bound equal amounts of 125I-HI and 125I-PI. There was no difference between HI- and PI-stimulated l...

journal_title：Diabetes

authors： Kumar D,Alexander CM,Zeidler A,Rhodes JJ,Boarman CC,Hoopes MT

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：:Recent studies have identified that the activation of protein kinase C (PKC) and increased diacylglycerol (DAG) levels initiated by hyperglycemia are associated with many vascular abnormalities in retinal, renal, and cardiovascular tissues. Among the various PKC isoforms, the beta- and delta-isoforms appear to be acti...

journal_title：Diabetes

authors： Koya D,King GL

更新日期：1998-06-01 00:00:00

abstract：:Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...

journal_title：Diabetes

authors： Takazakura E,Nakamoto Y,Hayakawa H,Kawai K,Muramoto S

更新日期：1975-01-01 00:00:00

abstract：:Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...

journal_title：Diabetes

authors： Ueda K,Takimoto E,Lu Q,Liu P,Fukuma N,Adachi Y,Suzuki R,Chou S,Baur W,Aronovitz MJ,Greenberg AS,Komuro I,Karas RH

更新日期：2018-08-01 00:00:00

abstract：:The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...

journal_title：Diabetes

authors： Sun L,Lin JD

更新日期：2019-05-01 00:00:00

abstract：:Leptin induces weight loss in rodents via its effects on food intake and energy expenditure. High-fat diets induce weight gain, but the mechanism is not well understood. Previous studies have not found an effect of dietary fat content on fasting leptin. There is a nocturnal increase of leptin, however, which is relate...

journal_title：Diabetes

authors： Havel PJ,Townsend R,Chaump L,Teff K

更新日期：1999-02-01 00:00:00

abstract：:The increased sugar transport was examined in the isolated small intestine of streptozotocin-diabetic rats. In the small intestine of these animals, the rate of glucose absorption in vivo is slightly increased, but not that of galactose of 3-O-MG (3-O-Methylglucose); however, in the isolated small intestine, the mucos...

journal_title：Diabetes

authors： Csáky TZ,Fischer E

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood....

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Toyoda T,Goodyear LJ

更新日期：2010-09-01 00:00:00

abstract：:Diabetes diagnostic therapy and research would strongly benefit from noninvasive accurate imaging of the functional β-cells in the pancreas. Here, we developed an analysis of functional β-cell mass (BCM) by measuring manganese (Mn(2+)) uptake kinetics into glucose-stimulated β-cells by T1-weighted in vivo Mn(2+)-media...

journal_title：Diabetes

authors： Meyer A,Stolz K,Dreher W,Bergemann J,Holebasavanahalli Thimmashetty V,Lueschen N,Azizi Z,Khobragade V,Maedler K,Kuestermann E

更新日期：2015-06-01 00:00:00

abstract：:Evidence exists for an essential role of beta-cell apoptosis in the pathology of type 1 and type 2 diabetes. Current methods for diabetes-associated apoptosis detection, however, suffer the drawbacks of relying on in situ-based strategies. In this study, we attempted to measure, both in vitro and ex vivo, levels of be...

journal_title：Diabetes

authors： Medarova Z,Bonner-Weir S,Lipes M,Moore A

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS:The FinnDiane Study has character...

journal_title：Diabetes

authors： Hietala K,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

更新日期：2008-08-01 00:00:00

abstract：:To explore metabolic changes associated with the sorbitol accumulation and myo-inositol depletion observed in glomeruli of rats with experimental diabetes, we examined total and ouabain-inhibited adenosine triphosphatase (ATPase) activity in glomeruli isolated from control and streptozocin (STZ)-diabetic rats. Glomeru...

journal_title：Diabetes

authors： Cohen MP,Dasmahapatra A,Shapiro E

更新日期：1985-11-01 00:00:00

abstract：:The enzyme activities of mitochondrial glycerol phosphate dehydrogenase (mGPD) (EC 1.1.99.5) and pyruvate carboxylase (PC) (EC 6.4.1.1) have been reported to be low in the pancreatic islet of several rodent models of NIDDM. The present study was undertaken to discern whether mGPD is abnormal in the Zucker diabetic fat...

journal_title：Diabetes

authors： MacDonald MJ,Tang J,Polonsky KS

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 ...

journal_title：Diabetes

authors： Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

更新日期：2020-08-01 00:00:00

abstract：:Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...

journal_title：Diabetes

authors： MacDonald MJ,Kowluru A

更新日期：1982-06-01 00:00:00

abstract：:In genetically obese leptin-deficient ob/ob mice, adrenalectomy reverses or attenuates the obese phenotype. Relative to lean controls, ob/ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA. It has been ...

journal_title：Diabetes

authors： Makimura H,Mizuno TM,Roberts J,Silverstein J,Beasley J,Mobbs CV

更新日期：2000-11-01 00:00:00

abstract：:Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass (FM) of lean C57B6 mice fed a high-fat diet (HFD; FMC mice) was "cla...

journal_title：Diabetes

authors： Kirchner H,Hofmann SM,Fischer-Rosinský A,Hembree J,Abplanalp W,Ottaway N,Donelan E,Krishna R,Woods SC,Müller TD,Spranger J,Perez-Tilve D,Pfluger PT,Tschöp MH,Habegger KM

更新日期：2012-11-01 00:00:00

abstract：:Rats from four experimental treatment groups, including fed controls, 24- to 30-h fasted, dexamethasone-treated, and intraperitoneal glucose-treated, were used to assess the effects of these treatments on the immunohistochemically detectable islet amyloid polypeptide (IAPP) content in the pancreatic islets. Isolated p...

journal_title：Diabetes

authors： O'Brien TD,Westermark P,Johnson KH

更新日期：1991-12-01 00:00:00

abstract：:The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1.B and RT1.D. The possibility that variant or unique class II MHC molecules m...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK

更新日期：1989-02-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular complications of type 2 diabetes. In liver, extracellular hepara...

journal_title：Diabetes

authors： Olsson U,Egnell AC,Lee MR,Lundén GO,Lorentzon M,Salmivirta M,Bondjers G,Camejo G

更新日期：2001-09-01 00:00:00

abstract：:For the period of 1 January 1979 through 31 December 1985, an average annual incidence rate (IR) of 12.1/100,000 (95% confidence interval [10.4/100,000, 14.0/100,000]) of insulin-dependent diabetes mellitus (IDDM) was observed in Jefferson County, Alabama, among people less than 20 yr old. Hospital medical-record revi...

journal_title：Diabetes

authors： Wagenknecht LE,Roseman JM,Alexander WJ

更新日期：1989-05-01 00:00:00

abstract：:Diabetic nephropathy is a major complication of diabetes and a leading cause of end-stage renal diseases in the U.S. Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor that has been extensively studied in diabetic retinopathy. Recently, we reported that PEDF is expressed at high levels in normal...

journal_title：Diabetes

authors： Wang JJ,Zhang SX,Mott R,Knapp RR,Cao W,Lau K,Ma JX

更新日期：2006-06-01 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of ...

journal_title：Diabetes

authors： Berglund LM,Lyssenko V,Ladenvall C,Kotova O,Edsfeldt A,Pilgaard K,Alkayyali S,Brøns C,Forsblom C,Jonsson A,Zetterqvist AV,Nitulescu M,McDavitt CR,Dunér P,Stancáková A,Kuusisto J,Ahlqvist E,Lajer M,Tarnow L,Madsbad S

更新日期：2016-01-01 00:00:00

abstract：:We reported earlier that β-cell-specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic fatty (ZDF) rats wit...

journal_title：Diabetes

authors： Mahadevan J,Parazzoli S,Oseid E,Hertzel AV,Bernlohr DA,Vallerie SN,Liu CQ,Lopez M,Harmon JS,Robertson RP

更新日期：2013-10-01 00:00:00

abstract：:Lifestyle modification reduces the risk of developing type 2 diabetes and may have its effect through improving insulin sensitivity, beta-cell function, or both. To determine whether diet and exercise improve insulin sensitivity and/or beta-cell function and to evaluate these effects over time, we quantified insulin s...

journal_title：Diabetes

authors： Carr DB,Utzschneider KM,Boyko EJ,Asberry PJ,Hull RL,Kodama K,Callahan HS,Matthys CC,Leonetti DL,Schwartz RS,Kahn SE,Fujimoto WY

更新日期：2005-02-01 00:00:00