Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.

abstract：:Recent evidence supports the strong overlap between genes implicated in monogenic diabetes and susceptibility to type 2 diabetes. Transient neonatal diabetes mellitus (TNDM) is a rare disorder associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24. There are two overlappin...

journal_title：Diabetes

authors： Gloyn AL,Mackay DJ,Weedon MN,McCarthy MI,Walker M,Hitman G,Knight BA,Owen KR,Hattersley AT,Frayling TM

更新日期：2006-08-01 00:00:00

abstract：:It is often stated that type 1 diabetes results from a complex interplay between varying degrees of genetic susceptibility and environmental factors. While agreeing with this principal, our desire is that this Perspectives article will highlight another complex interplay potentially associated with this disease involv...

journal_title：Diabetes

authors： Vaarala O,Atkinson MA,Neu J

更新日期：2008-10-01 00:00:00

abstract：:Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

journal_title：Diabetes

authors： Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

更新日期：2020-09-01 00:00:00

abstract：:Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular...

journal_title：Diabetes

authors： McMillan DE

更新日期：1976-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER are only partially defined in these cells, ...

journal_title：Diabetes

authors： Varadi A,Rutter GA

更新日期：2002-02-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00

abstract：:Duct-occluded segmental-pancreas transplants develop progressive fibrotic atrophy, even though endocrine function seems to be unaffected. To determine end-stage size of the graft and to evaluate magnetic resonance imaging (MRI) and computed tomography (CT), these imaging techniques were applied in eight patients with ...

journal_title：Diabetes

authors： Schlumpf R,Marincek B,Von Schulthess G,Decurtins M,Largiadèr F

更新日期：1989-01-01 00:00:00

abstract：:T-1095A and T-1095 are synthetic agents derived from phlorizin, a specific inhibitor of Na+-glucose cotransporters (SGLTs). Unlike phlorizin, T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney. Orally administe...

journal_title：Diabetes

authors： Oku A,Ueta K,Arakawa K,Ishihara T,Nawano M,Kuronuma Y,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T,Kanai Y,Endou H

更新日期：1999-09-01 00:00:00

abstract：:Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

journal_title：Diabetes

authors： Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

更新日期：2014-07-01 00:00:00

abstract：:Treatment of male sand rats kept on a balanced laboratory chow diet ad libitum with beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a hypolipidemic effect accompanied by an extensive reduction in adiposity, with a concomitant hypoglycemic-hypoinsulinemic effect. The overall effect was s...

journal_title：Diabetes

authors： Tzur R,Rose-Kahn G,Adler JH,Bar-Tana J

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:Triglycerides in the beta-cell may be important for stimulus-secretion coupling, through provision of a lipid-derived signal, and for pathogenetic events in NIDDM, where lipids may adversely affect beta-cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in triglyceride hydrolysis. Here,...

journal_title：Diabetes

authors： Mulder H,Holst LS,Svensson H,Degerman E,Sundler F,Ahrén B,Rorsman P,Holm C

更新日期：1999-01-01 00:00:00

abstract：:The decline of leptin (Ob protein) concentrations during fasting is implicated as a signal for increasing the expression of the orexigenic peptide neuropeptide Y (NPY) in the hypothalamus. To test the hypothesis that the effects of food intake on arcuate nucleus NPY activation are mediated by leptin, we performed simu...

journal_title：Diabetes

authors： Baskin DG,Breininger JF,Schwartz MW

更新日期：1999-04-01 00:00:00

abstract：:Tolbutamide (1 g/kg body wt) was administered to male rats for 3 days to determine the effects of this pretreatment on subsequent insulin biosynthesis and compartmental storage characteristics of freshly isolated islets. Islets were isolated 16 h after the last tolbutamide administration, at a time when fed plasma glu...

journal_title：Diabetes

authors： Gold G,Pou J,Gishizky ML,Landahl HD,Grodsky GM

更新日期：1986-01-01 00:00:00

abstract：:As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein-coupled inwardly rectifying potassium channels expressed in beta-cells (KCNJ3 and KCNJ7), glucagon (GCG), glucokinase regul...

journal_title：Diabetes

authors： Vionnet N,Hani EH,Lesage S,Philippi A,Hager J,Varret M,Stoffel M,Tanizawa Y,Chiu KC,Glaser B,Permutt MA,Passa P,Demenais F,Froguel P

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS A...

journal_title：Diabetes

authors： McGee SL,van Denderen BJ,Howlett KF,Mollica J,Schertzer JD,Kemp BE,Hargreaves M

更新日期：2008-04-01 00:00:00

abstract：:There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...

journal_title：Diabetes

authors： Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

更新日期：1997-01-01 00:00:00

abstract：:Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., r...

journal_title：Diabetes

authors： Lara-Castro C,Luo N,Wallace P,Klein RL,Garvey WT

更新日期：2006-01-01 00:00:00

abstract：:Glucose controls islet beta-cell mass and function at least in part through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription factors known in other tissues to be negatively regulated by Akt activation, affect proliferation and metabolism. In this st...

journal_title：Diabetes

authors： Martinez SC,Cras-Méneur C,Bernal-Mizrachi E,Permutt MA

更新日期：2006-06-01 00:00:00

abstract：:Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this disease is not well understood. An inflammatory process is linked to the onset of experimental diabetic retinopathy. CD40 deficiency impairs this process and preve...

journal_title：Diabetes

authors： Portillo JC,Lopez Corcino Y,Miao Y,Tang J,Sheibani N,Kern TS,Dubyak GR,Subauste CS

更新日期：2017-02-01 00:00:00

abstract：:This study addressed the controversial question of whether a negative-insulin-feedback loop exists in vivo. We utilized prehepatic insulin production, calculated by computerized deconvolution analysis of peripheral C-peptide concentration, as a measure of endogenous insulin secretion. Prehepatic insulin production was...

journal_title：Diabetes

authors： Argoud GM,Schade DS,Eaton RP

更新日期：1987-08-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the recruitment of autoaggressive lymphocytes to the islets of Langerhans. Transplantation of isolated islets as a promising therapy...

journal_title：Diabetes

authors： Bender C,Christen S,Scholich K,Bayer M,Pfeilschifter JM,Hintermann E,Christen U

更新日期：2017-01-01 00:00:00

abstract：:Neonatal rats injected with streptozocin (STZ, 100 mg/kg) at birth exhibited an acute diabetes followed by a spontaneous remission. We have previously shown that this recovery from neonatal diabetes is due to B-cell regeneration and reaccumulation of pancreatic insulin stores starting from 3 to 5 days after birth. The...

journal_title：Diabetes

authors： Portha B,Kergoat M

更新日期：1985-06-01 00:00:00

abstract：:The influence of cyclic AMP (cAMP) and extracellular calcium on phosphoinositide (PI) hydrolysis in isolated islets was assessed and related to insulin output. Three stimulants were chosen to activate the beta-cell: sulfated cholecystokinin (CCK-8S, 200 nM), high-level glucose (20 mM), and the sulfonylurea tolbutamide...

journal_title：Diabetes

authors： Zawalich WS,Diaz VA,Zawalich KC

更新日期：1988-11-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

journal_title：Diabetes

authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

更新日期：1986-04-01 00:00:00

abstract：:Rare mutations in the proopiomelanocortin (POMC) gene cause severe early-onset childhood obesity. However, it is unknown whether common variants in POMC are responsible for variation in body weight or fat distribution within the commonly observed range in the population. We tested for association between three polymor...

journal_title：Diabetes

authors： Baker M,Gaukrodger N,Mayosi BM,Imrie H,Farrall M,Watkins H,Connell JM,Avery PJ,Keavney B

更新日期：2005-08-01 00:00:00

abstract：:Complementary DNA encoding three catalytic subunits of protein phosphatase 1 (PP1 alpha, PP1 beta, and PP1 gamma) and the insulin-stimulated protein kinase 1 (ISPK-1) was analyzed for variations in the coding regions related to insulin-resistant glycogen synthesis in skeletal muscle of 30 patients with non-insulin-dep...

journal_title：Diabetes

authors： Bjørbaek C,Vik TA,Echwald SM,Yang PY,Vestergaard H,Wang JP,Webb GC,Richmond K,Hansen T,Erikson RL

更新日期：1995-01-01 00:00:00

abstract：:Although decreased levels of circulating insulinlike growth factor I (IGF-I) and hepatic IGF-I mRNA in diabetic animal models support a role for insulin in IGF-I regulation, it has been difficult to study the effects of insulin in vitro. Few immortal cell lines exhibit hormone-responsive production of IGF-I, and studi...

journal_title：Diabetes

authors： Phillips LS,Goldstein S,Pao CI

更新日期：1991-11-01 00:00:00