Changes in blood flow close to subcutaneous insulin injection sites in stable and brittle diabetics.

abstract：:Antibodies to islet cell proteins detected as 37,000 and 40,000 M(r), tryptic fragments (37- and 40-kDa antigens) are strongly associated with progression to IDDM. The 40-kDa antigen has recently been identified as the tyrosine phosphatase-like protein IA-2 (ICA512) whereas the 37-kDa antigen has been suggested to be ...

journal_title：Diabetes

authors： Hawkes CJ,Wasmeier C,Christie MR,Hutton JC

更新日期：1996-09-01 00:00:00

abstract：:Sera from rats inoculated with in vitro glucosylated rat skin acid-soluble collagen were evaluated for specific antibody response using the enzyme-linked immunosorbent assay. The data indicate that the altered protein is capable of eliciting the production of antibodies, but unmodified collagen is not. The specificity...

journal_title：Diabetes

authors： Bassiouny AR,Rosenberg H,McDonald TL

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Kumashiro N,Tamura Y,Uchida T,Ogihara T,Fujitani Y,Hirose T,Mochizuki H,Kawamori R,Watada H

更新日期：2008-08-01 00:00:00

abstract：:To develop somatic gene therapy for diabetes, we studied an animal model with proinsulin-producing fibroblasts with an immunological safety system. Cultured mouse fibroblasts of the Ltk- cell line were transfected first with the efficient human proinsulin expression vector pBMG-Neo-Ins. Initially, 2 x 10(6) cells with...

journal_title：Diabetes

authors： Kawakami Y,Yamaoka T,Hirochika R,Yamashita K,Itakura M,Nakauchi H

更新日期：1992-08-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral glucose absorption that regulates glucose metabolism and cardiovascular function. GLP-1 is also pro...

journal_title：Diabetes

authors： Cabou C,Campistron G,Marsollier N,Leloup C,Cruciani-Guglielmacci C,Pénicaud L,Drucker DJ,Magnan C,Burcelin R

更新日期：2008-10-01 00:00:00

abstract：:The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER are only partially defined in these cells, ...

journal_title：Diabetes

authors： Varadi A,Rutter GA

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Leptin induces weight loss in rodents via its effects on food intake and energy expenditure. High-fat diets induce weight gain, but the mechanism is not well understood. Previous studies have not found an effect of dietary fat content on fasting leptin. There is a nocturnal increase of leptin, however, which is relate...

journal_title：Diabetes

authors： Havel PJ,Townsend R,Chaump L,Teff K

更新日期：1999-02-01 00:00:00

abstract：:Aldose reductase (AR) was purified from rat seminal vesicles. Specific antibodies to this enzyme were prepared in rabbits and were used in the unlabeled antibody-enzyme (PAP) technique to localize AR in a number of tissues known to be sites of diabetic lesions. AR was localized in the following structures in the eye: ...

journal_title：Diabetes

authors： Ludvigson MA,Sorenson RL

更新日期：1980-06-01 00:00:00

abstract：:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...

journal_title：Diabetes

authors： McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JR

更新日期：1988-03-01 00:00:00

abstract：:Numerous reports have confirmed the presence of islet cell antibodies in diabetic patients. These are found mostly in newly diagnosed insulin-dependent diabetic patients and in patients who have autoimmune polyendocrine disorders. Antibodies to beta cells, somatostatin, and glucagon-producing cells have been described...

journal_title：Diabetes

authors： Kaldany A

更新日期：1979-02-01 00:00:00

abstract：:Diabetic hypoglycemia produces cognitive-motor slowing, which is assumed to increase risk of automobile crashes. This study investigated driving decrements during and after hypoglycemia, and the patients' awareness of driving decrements. We used a randomized, single-blind, crossover design and conducted the study at t...

journal_title：Diabetes

authors： Cox DJ,Gonder-Frederick L,Clarke W

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：:Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...

journal_title：Diabetes

authors： de Souza CJ,Eckhardt M,Gagen K,Dong M,Chen W,Laurent D,Burkey BF

更新日期：2001-08-01 00:00:00

abstract：:To assess the extent to which the progression of diabetic retinopathy can be arrested by improved glycemic control, 35 normal dogs were randomly divided into a nondiabetic and three alloxan-induced diabetic groups prospectively identified according to glycemic control: poor control for 5 yr (PC), good control for 5 yr...

journal_title：Diabetes

authors： Engerman RL,Kern TS

更新日期：1987-07-01 00:00:00

abstract：:Elevated urinary albumin excretion (UAE) is a predictor of the development of nephropathy and cardiovascular mortality. To study whether genetic factors may determine UAE, we examined familial aggregation of UAE in 96 large multigenerational pedigrees ascertained for type 2 diabetes. A total of 1,269 subjects had UAE ...

journal_title：Diabetes

authors： Fogarty DG,Hanna LS,Wantman M,Warram JH,Krolewski AS,Rich SS

更新日期：2000-06-01 00:00:00

abstract：:Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a gut hormone, is rapidly induced by bariatric surgery in rodents and humans. Administration of FGF19 achieves diabetes remission ind...

journal_title：Diabetes

authors： DePaoli AM,Zhou M,Kaplan DD,Hunt SC,Adams TD,Learned RM,Tian H,Ling L

更新日期：2019-06-01 00:00:00

abstract：:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of...

journal_title：Diabetes

authors： Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

更新日期：1983-05-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...

journal_title：Diabetes

authors： Virji MA,Steffes MW,Estensen RD

更新日期：1984-02-01 00:00:00

abstract：:Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...

journal_title：Diabetes

authors： Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

更新日期：2012-07-01 00:00:00

abstract：:The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a novel approach aimed at protecting islets before Tx in nonhuman prima...

journal_title：Diabetes

authors： Pomposelli T,Wang P,Takeuchi K,Miyake K,Ariyoshi Y,Watanabe H,Chen X,Shimizu A,Robertson N,Yamada K,Moore A

更新日期：2020-11-01 00:00:00

abstract：:Studies in 10 nonketotic diabetic subjects (five juvenile- and five adult-onset) before and after control of carbohydrate metabolism showed a high degree of correlation between hemoglobin AIc (HbAIc) concentrations and serum triglyceride levels. Serum triglyceride levels were found to correlate more closely with Hb AI...

journal_title：Diabetes

authors： Peterson CM,Koenig RJ,Jones RL,Saudek CD,Cerami A

更新日期：1977-05-01 00:00:00

abstract：:Data is accumulating indicating that impaired insulin action predisposes to increased vascular smooth muscle (VSM) tone, the hallmark of hypertension associated with diabetes. During the last several years, it has been established that VSM is an insulin-sensitive tissue like skeletal muscle and adipocytes. Investigato...

journal_title：Diabetes

authors： Sowers JR

更新日期：1996-07-01 00:00:00

abstract：:Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe) vein at a rate fou...

journal_title：Diabetes

authors： Gregory JM,Kraft G,Scott MF,Neal DW,Farmer B,Smith MS,Hastings JR,Allen EJ,Donahue EP,Rivera N,Winnick JJ,Edgerton DS,Nishimura E,Fledelius C,Brand CL,Cherrington AD

更新日期：2015-10-01 00:00:00

abstract：:A double-blind crossover study of fludrocortisone, 0,1 mg. twice daily, and placebo is reported in six diabetics with troublesome symptoms of postural hypotension due to autonomic neuropathy. During treatment with the active preparation there was an increase in the lying and tilted systolic blood pressure, a decrease ...

journal_title：Diabetes

authors： Campbell IW,Ewing DJ,Clarke BF

更新日期：1975-04-01 00:00:00

abstract：:Complementary DNA encoding three catalytic subunits of protein phosphatase 1 (PP1 alpha, PP1 beta, and PP1 gamma) and the insulin-stimulated protein kinase 1 (ISPK-1) was analyzed for variations in the coding regions related to insulin-resistant glycogen synthesis in skeletal muscle of 30 patients with non-insulin-dep...

journal_title：Diabetes

authors： Bjørbaek C,Vik TA,Echwald SM,Yang PY,Vestergaard H,Wang JP,Webb GC,Richmond K,Hansen T,Erikson RL

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...

journal_title：Diabetes

authors： Klinger S,Poussin C,Debril MB,Dolci W,Halban PA,Thorens B

更新日期：2008-03-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...

journal_title：Diabetes

authors： Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

更新日期：2015-10-01 00:00:00