Determination of encephalomyocarditis viral diabetogenicity by a putative binding site of the viral capsid protein.

abstract：OBJECTIVE:Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial inju...

journal_title：Diabetes

authors： Noyan-Ashraf MH,Momen MA,Ban K,Sadi AM,Zhou YQ,Riazi AM,Baggio LL,Henkelman RM,Husain M,Drucker DJ

更新日期：2009-04-01 00:00:00

abstract：:Diabetogenic strains of Coxsackievirus B4 (CB4) produce a diabetes syndrome in susceptible mice that resembles insulin-dependent diabetes mellitus. To assess the possible role of autoimmunity, the expression of a 64,000-Mr islet antigen in SJL/J and CD1 mice infected with a diabetogenic strain of CB4 was monitored in ...

journal_title：Diabetes

authors： Gerling I,Nejman C,Chatterjee NK

更新日期：1988-10-01 00:00:00

abstract：:The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

journal_title：Diabetes

authors： Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

更新日期：2002-12-01 00:00:00

abstract：:We assessed our speculation that 2-cyclohexen-1-one (CHX) impairs glucose-induced insulin secretion through inactivation of glucokinase. Treatment of pancreatic islets with CHX at concentrations (0-5 mM) that caused a dose-dependent inactivation of glucokinase activity similarly inhibited glucose-induced insulin secre...

journal_title：Diabetes

authors： Miwa I,Murata T,Mitsuyama S,Okuda J

更新日期：1990-10-01 00:00:00

abstract：:Twenty-four-hour patterns of plasma growth hormone concentrations were evaluated during 50 studies of 42 subjects with juvenile-onset diabetes mellitus. Blood was sampled continuously over 24 h using a portable peristaltic pump under conditions in which subjects remained ambulatory and maintained their daily dietary a...

journal_title：Diabetes

authors： Hayford JT,Danney MM,Hendrix JA,Thompson RG

更新日期：1980-05-01 00:00:00

abstract：:New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...

journal_title：Diabetes

authors： Pinies JA,Fu Y,Vazquez JA,Faustman D

更新日期：1997-03-01 00:00:00

abstract：:Studies were conducted to clarify the relationship between the external fatty acid concentration and glucagon in the regulation of hepatic fatty acid metabolism. Hepatocytes from fed rats were incubated with increasing concentrations of oleate (up to 1 mM) in the presence and absence of glucagon and the time sequence ...

journal_title：Diabetes

authors： McGarry JD,Foster DW

更新日期：1980-03-01 00:00:00

abstract：:I investigated biochemical parameters of sympathetic nerve function in spontaneously diabetic mice(C57 BL/KsJdb/db) and in their lean littermates. The concentration of norepinephrine (NE) in organs innervated by sympathetic nerves was significantly reduced in the heart, kidney, and salivary glands of mice (24 weeks ol...

journal_title：Diabetes

authors： Giachetti A

更新日期：1978-10-01 00:00:00

abstract：:Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...

journal_title：Diabetes

authors： Ryan EA,Shandro T,Green K,Paty BW,Senior PA,Bigam D,Shapiro AM,Vantyghem MC

更新日期：2004-04-01 00:00:00

abstract：:Glucose controls islet beta-cell mass and function at least in part through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription factors known in other tissues to be negatively regulated by Akt activation, affect proliferation and metabolism. In this st...

journal_title：Diabetes

authors： Martinez SC,Cras-Méneur C,Bernal-Mizrachi E,Permutt MA

更新日期：2006-06-01 00:00:00

abstract：:Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has ...

journal_title：Diabetes

authors： Finegold D,Lattimer SA,Nolle S,Bernstein M,Greene DA

更新日期：1983-11-01 00:00:00

abstract：:Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

journal_title：Diabetes

authors： Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ...

journal_title：Diabetes

authors： Grarup N,Andersen G,Krarup NT,Albrechtsen A,Schmitz O,Jørgensen T,Borch-Johnsen K,Hansen T,Pedersen O

更新日期：2008-09-01 00:00:00

abstract：:Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which...

journal_title：Diabetes

authors： Singh LP,Andy J,Anyamale V,Greene K,Alexander M,Crook ED

更新日期：2001-10-01 00:00:00

abstract：:Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...

journal_title：Diabetes

authors： Thelin MA,Kissler S,Vigneault F,Watters AL,White D,Koshy ST,Vermillion SA,Mooney DJ,Serwold T,Ali OA

更新日期：2017-08-01 00:00:00

abstract：:To explain the contradictory data on the secretion of prostacyclin (PGI2) in clinical and experimental diabetes, we have investigated the effect of each of the major metabolic abnormalities in uncontrolled diabetes on vascular PGI2 synthesis. An increase in fatty acid concentrations caused a dose-dependent inhibition ...

journal_title：Diabetes

authors： Jeremy JY,Mikhailidis DP,Dandona P

更新日期：1983-03-01 00:00:00

abstract：:The peripheral nerve disorders associated with diabetes are complex and probably involve a variety of causative mechanisms. This may give rise to difficulty in the classification of individual cases. A broad separation into rapidly reversible or more persistent phenomena is helpful. The former, which can be categorize...

journal_title：Diabetes

authors： Thomas PK

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Bariatric surgery causes durable weight loss. Gut hormones are implicated in obesity pathogenesis, dietary failure, and mediating gastrointestinal bypass (GIBP) surgery weight loss. In mice, we determined the effects of diet-induced obesity (DIO), subsequent dieting, and GIBP surgery on ghrelin, peptide YY (P...

journal_title：Diabetes

authors： Chandarana K,Gelegen C,Karra E,Choudhury AI,Drew ME,Fauveau V,Viollet B,Andreelli F,Withers DJ,Batterham RL

更新日期：2011-03-01 00:00:00

abstract：:Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured...

journal_title：Diabetes

authors： Wajngot A,Alvarsson M,Glaser A,Efendic S,Luthman H,Grill V

更新日期：1994-12-01 00:00:00

abstract：:To determine the relationship between insulin sensitivity and beta-cell function, we quantified the insulin sensitivity index using the minimal model in 93 relatively young, apparently healthy human subjects of varying degrees of obesity (55 male, 38 female; 18-44 yr of age; body mass index 19.5-52.2 kg/m2) and with f...

journal_title：Diabetes

authors： Kahn SE,Prigeon RL,McCulloch DK,Boyko EJ,Bergman RN,Schwartz MW,Neifing JL,Ward WK,Beard JC,Palmer JP

更新日期：1993-11-01 00:00:00

abstract：:With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations betwee...

journal_title：Diabetes

authors： Elhadad MA,Jonasson C,Huth C,Wilson R,Gieger C,Matias P,Grallert H,Graumann J,Gailus-Durner V,Rathmann W,von Toerne C,Hauck SM,Koenig W,Sinner MF,Oprea TI,Suhre K,Thorand B,Hveem K,Peters A,Waldenberger M

更新日期：2020-12-01 00:00:00

abstract：:Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute regulation of glucokinase activity has been shown to occur via a regulatory protein found in liver parenchymal cells (Van Schaftingen E, Detheux M, Da Cunha MV....

journal_title：Diabetes

authors： Mookhtiar KA,Kalinowski SS,Brown KS,Tsay YH,Smith-Monroy C,Robinson GW

更新日期：1996-12-01 00:00:00

abstract：:Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression ...

journal_title：Diabetes

authors： Keildson S,Fadista J,Ladenvall C,Hedman ÅK,Elgzyri T,Small KS,Grundberg E,Nica AC,Glass D,Richards JB,Barrett A,Nisbet J,Zheng HF,Rönn T,Ström K,Eriksson KF,Prokopenko I,MAGIC Consortium.,DIAGRAM Consortium.,MuTHER

更新日期：2014-03-01 00:00:00

abstract：:Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...

journal_title：Diabetes

authors： Sandhu MS,Gibson JM,Heald AH,Dunger DB,Wareham NJ

更新日期：2003-06-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：:Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We recently showed that Munc13-1 is expressed in rodent and human islet beta-cells and that its levels are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 deficiency contributes to the abnor...

journal_title：Diabetes

authors： Kwan EP,Xie L,Sheu L,Nolan CJ,Prentki M,Betz A,Brose N,Gaisano HY

更新日期：2006-05-01 00:00:00

abstract：:This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...

journal_title：Diabetes

authors： Price SA,Agthong S,Middlemas AB,Tomlinson DR

更新日期：2004-07-01 00:00:00

abstract：:Leptin and glucagon-like peptide 1 (GLP-1) exhibit opposing actions in the endocrine pancreas. GLP-1 stimulates insulin biosynthesis, secretion, and islet growth, whereas leptin inhibits glucose-dependent insulin secretion and insulin gene transcription. In contrast, GLP-1 and leptin actions overlap in the central ner...

journal_title：Diabetes

authors： Scrocchi LA,Hill ME,Saleh J,Perkins B,Drucker DJ

更新日期：2000-09-01 00:00:00

abstract：:We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment of 3-hydroxy-Acyl-CoA-dehydrogenase (HAD) and cit...

journal_title：Diabetes

authors： Mogensen M,Sahlin K,Fernström M,Glintborg D,Vind BF,Beck-Nielsen H,Højlund K

更新日期：2007-06-01 00:00:00

abstract：:Rats with chronic streptozotocin (SZ) diabetes develop dilatation of the alimentary tract, loss of fecal consistency, and autonomic neuropathy involving unmyelinated axons of the extrinsic innervation of the small bowel. Diabetic autonomic neuropathy involving the ileal mesenteric nerves is characterized by modest to ...

journal_title：Diabetes

authors： Schmidt RE,Plurad SB,Olack BJ,Scharp DW

更新日期：1983-06-01 00:00:00