Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.

abstract：:We previously described a prosthetic group methodology for incorporating 18F into peptides and showed that 18F-labeled insulin (18F-insulin) binds to insulin receptors on human cells (IM-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). We now report studies using 18F-insulin with positron emi...

journal_title：Diabetes

authors： Eastman RC,Carson RE,Jacobson KA,Shai Y,Channing MA,Dunn BB,Bacher JD,Baas E,Jones E,Kirk KL

更新日期：1992-07-01 00:00:00

abstract：:Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging mammals and are frequently associated with leptin resistance and increased plasma leptin levels. To examine whether leptin's failure in aging is due to aging per se or to changes in body fat mass or distribution, we studied a...

journal_title：Diabetes

authors： Gabriely I,Ma XH,Yang XM,Rossetti L,Barzilai N

更新日期：2002-04-01 00:00:00

abstract：:As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein-coupled inwardly rectifying potassium channels expressed in beta-cells (KCNJ3 and KCNJ7), glucagon (GCG), glucokinase regul...

journal_title：Diabetes

authors： Vionnet N,Hani EH,Lesage S,Philippi A,Hager J,Varret M,Stoffel M,Tanizawa Y,Chiu KC,Glaser B,Permutt MA,Passa P,Demenais F,Froguel P

更新日期：1997-06-01 00:00:00

abstract：:In this study, 92% of patients' serums known to contain antibodies against islet cells, including the Juvenile Diabetes Foundation provisional reference serum, had antibodies reacting with gastrointestinal carcinoid tumors. Twelve percent of the control serums from healthy individuals bound to carcinoid cells, and 2% ...

journal_title：Diabetes

authors： Miettinen A,Holthöfer H,Kontiainen S,Miettinen M,Andersson LC

更新日期：1989-05-01 00:00:00

abstract：:Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stre...

journal_title：Diabetes

authors： Okuno Y,Fukuhara A,Hashimoto E,Kobayashi H,Kobayashi S,Otsuki M,Shimomura I

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...

journal_title：Diabetes

authors： Varma V,Yao-Borengasser A,Bodles AM,Rasouli N,Phanavanh B,Nolen GT,Kern EM,Nagarajan R,Spencer HJ 3rd,Lee MJ,Fried SK,McGehee RE Jr,Peterson CA,Kern PA

更新日期：2008-02-01 00:00:00

abstract：:The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...

journal_title：Diabetes

authors： James EA,Mallone R,Kent SC,DiLorenzo TP

更新日期：2020-07-01 00:00:00

abstract：:Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of ty...

journal_title：Diabetes

authors： Knip M,Veijola R,Virtanen SM,Hyöty H,Vaarala O,Akerblom HK

更新日期：2005-12-01 00:00:00

abstract：:Altered proteoglycan metabolism may play a role in the development of diabetic glomerulopathy. This study was conducted to examine the effects of glucose on the production and physical characteristics of proteoglycans generated by rat mesangial cells in culture. Rat mesangial cells were exposed to elevated glucose med...

journal_title：Diabetes

authors： Silbiger S,Schlondorff D,Crowley S,Rosenberg L,Choi H,Hatcher V,Gordon P

更新日期：1993-12-01 00:00:00

abstract：:AS160 is a newly described substrate for the protein kinase Akt that links insulin signaling and GLUT4 trafficking. In this study, we determined the expression of and in vivo insulin action on AS160 in human skeletal muscle. In addition, we compared the effect of physiological hyperinsulinemia on AS160 phosphorylation...

journal_title：Diabetes

authors： Karlsson HK,Zierath JR,Kane S,Krook A,Lienhard GE,Wallberg-Henriksson H

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression might therefore prev...

journal_title：Diabetes

authors： Oeser JK,Parekh VV,Wang Y,Jegadeesh NK,Sarkar SA,Wong R,Lee CE,Pound LD,Hutton JC,Van Kaer L,O'Brien RM

更新日期：2011-11-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the biological activity of GIP in vivo is still largely unknown. In nonfasted anesthetized pigs given an intravenous infusion of ...

journal_title：Diabetes

authors： Deacon CF,Danielsen P,Klarskov L,Olesen M,Holst JJ

更新日期：2001-07-01 00:00:00

abstract：:The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...

journal_title：Diabetes

authors： Bingham EM,Hopkins D,Smith D,Pernet A,Hallett W,Reed L,Marsden PK,Amiel SA

更新日期：2002-12-01 00:00:00

abstract：:Defects in insulin secretion, resulting from loss of function or destruction of pancreatic beta-cells, trigger diabetes. Interleukin (IL)-1beta is a proinflammatory cytokine that is involved in type 1 and type 2 diabetes development and impairs beta-cell survival and function. Because effective insulin signaling is re...

journal_title：Diabetes

authors： Emanuelli B,Glondu M,Filloux C,Peraldi P,Van Obberghen E

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages. RESEARCH DESIGN AND METHODS:We determined cytokine pro...

journal_title：Diabetes

authors： Su D,Coudriet GM,Hyun Kim D,Lu Y,Perdomo G,Qu S,Slusher S,Tse HM,Piganelli J,Giannoukakis N,Zhang J,Dong HH

更新日期：2009-11-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3'-UTR of IKZF1 with C-ALL susceptibility, we tested...

journal_title：Diabetes

authors： Swafford AD,Howson JM,Davison LJ,Wallace C,Smyth DJ,Schuilenburg H,Maisuria-Armer M,Mistry T,Lenardo MJ,Todd JA

更新日期：2011-03-01 00:00:00

abstract：:Misregulated hormone secretion from the islet of Langerhans is central to the pathophysiology of diabetes. Although insulin plays a key role in glucose regulation, the importance of glucagon is increasingly acknowledged. However, the mechanisms that regulate glucagon secretion from α-cells are still unclear. We used p...

journal_title：Diabetes

authors： Reissaus CA,Piston DW

更新日期：2017-04-01 00:00:00

abstract：:This article examines the role of the autonomic nervous system in mediating the increase of glucagon secretion observed during insulin-induced hypoglycemia (IIH). In the first section, we briefly review the importance of the alpha-cell response in recovery from hypoglycemia under both physiologic conditions and pathop...

journal_title：Diabetes

authors： Taborsky GJ Jr,Ahrén B,Havel PJ

更新日期：1998-07-01 00:00:00

abstract：:Repeated large-volume blood withdrawals started at a young age previously appeared to correct lymphopenia and prevent diabetes in Ottawa diabetes-prone BB (BBdp) rats. Therefore, we sought an early effect 24 h after withdrawal of 25% of estimated blood volume and then reexamined the long-term effects in BBdp rats. The...

journal_title：Diabetes

authors： Marliss EB,Métroz-Dayer MD,Montambault M,Faucher M,Grose M

更新日期：1990-09-01 00:00:00

abstract：:The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

journal_title：Diabetes

authors：

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:Phogrin and IA-2, autoantigens in insulin-dependent diabetes, have been shown to be involved in insulin secretion in pancreatic beta-cells; however, implications at a molecular level are confusing from experiment to experiment. We analyzed biological functions of phogrin in beta-cells by an RNA interference t...

journal_title：Diabetes

authors： Torii S,Saito N,Kawano A,Hou N,Ueki K,Kulkarni RN,Takeuchi T

更新日期：2009-03-01 00:00:00

abstract：:Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endog...

journal_title：Diabetes

authors： Dhawan S,Dirice E,Kulkarni RN,Bhushan A

更新日期：2016-05-01 00:00:00

abstract：:To evaluate the effects of gestational hyperglycemia on glucose metabolism and its regulation in the fasted rat during the early postnatal period, unrestrained rats were continuously infused with glucose during the last week of pregnancy. Control rats were infused with distilled water. Newborns were studied during the...

journal_title：Diabetes

authors： Nurjhan N,Ktorza A,Ferre P,Girard JR,Picon L

更新日期：1985-10-01 00:00:00

abstract：:An accelerated accumulation of advanced glycation end products (AGEs) occurs in diabetes secondary to the increased glycemic burden. In this study, we investigated the contribution of AGEs to intravascular oxidant stress by examining their action on the neutrophil burst of reactive oxygen species (ROS); this may be a ...

journal_title：Diabetes

authors： Wong RK,Pettit AI,Davies JE,Ng LL

更新日期：2002-09-01 00:00:00

abstract：:O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment ofN-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. Glucose-induced insulin resistance is mediated by increased ac...

journal_title：Diabetes

authors： Akimoto Y,Kreppel LK,Hirano H,Hart GW

更新日期：1999-12-01 00:00:00

abstract：:Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progres...

journal_title：Diabetes

authors： Triolo G,Davi' G,Giardina E,Cardella F,Meli F,La Grutta A,Strano A,Bompiani GD

更新日期：1984-08-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：:Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

journal_title：Diabetes

authors： Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

更新日期：2003-07-01 00:00:00

abstract：:Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma MGO levels are associated with incident CVD in people with type 1 diabetes is unknown. We included 159 individuals with pers...

journal_title：Diabetes

authors： Hanssen NMJ,Scheijen JLJM,Jorsal A,Parving HH,Tarnow L,Rossing P,Stehouwer CDA,Schalkwijk CG

更新日期：2017-08-01 00:00:00