abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...

journal_title：Medical hypotheses

authors： O'Kennedy N,Duttaroy AK

更新日期：2021-01-04 00:00:00

abstract：:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...

journal_title：Medical hypotheses

authors： Farhadi P,Yarani R,Kiani S,Mansouri K

更新日期：2021-01-01 00:00:00

abstract：:Low carbohydrate high fat (LCHF) diets are emerging in popularity. Several athletics have adopted LCHF diets in an attempt to improve exercise performance and body composition by enhancing fat utilization. However, these diets impair maximal and supramaximal exercise performance due to limited glycogen stores as well ...

journal_title：Medical hypotheses

authors： Kaviani M,Izadi A,Heshmati J

更新日期：2021-01-01 00:00:00

abstract：:The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...

journal_title：Medical hypotheses

authors： Venkatesh R,Reddy NG,Chhablani J

更新日期：2021-01-01 00:00:00

abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...

journal_title：Medical hypotheses

authors： Wee AKH

更新日期：2021-01-01 00:00:00

abstract：:Chronic Interstitial Nephritis in Agricultural Communities (CINAC) continues to attract controversy in the scientific community. It was previously known as Chronic Kidney Disease of Unknown Etiology (CKDu) and is not associated with the common aetiological factors such as diabetes. There is general acceptance that it ...

journal_title：Medical hypotheses

authors： Rodrigo C,Nawarathne P,Jayasinghe S

更新日期：2021-01-01 00:00:00

abstract：:Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative diseases of oral mucosa affecting an estimate of 20% of the world's population. Majority of the people affected by RAS are under 30 years of age. RAS is located on the lining (non-keratinized) oral mucosa, i.e. buccal mucosa, lateral side of the tongue,...

journal_title：Medical hypotheses

authors： Pärssinen M,Jäsberg H,Mikkonen JJW,Kullaa AM

更新日期：2021-01-01 00:00:00

abstract：:The prevalence of autism has increased dramatically over the last 60 years, and the cause of this increase is unclear. In this paradigm-shift paper, I propose an explanatory paradigm for the cause of autism and its increased prevalence in the general population. I also discuss how social and historical contexts may ha...

journal_title：Medical hypotheses

authors： McDonald TAM

更新日期：2021-01-01 00:00:00

abstract：:At the end of 2019, an emerging outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first reported from Wuhan, China. The first manifestations of patients infected with SARS-CoV-2 was flu-like symptoms, while other type of manifestations, especially gastrointestinal manifestations were...

journal_title：Medical hypotheses

authors： Nejadghaderi SA,Nazemalhosseini-Mojarad E,Asadzadeh Aghdaei H

更新日期：2020-12-31 00:00:00

abstract：:Several studies have described unusually high incidence of vascular thrombosis in coronavirus disease-2019 (COVID-19) patients. Pathogenesis of the vascular thrombosis in COVID-19 is least understood for now and presents a challenge to the treating physicians. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-...

journal_title：Medical hypotheses

authors： Kumar A,Narayan RK,Kumari C,Faiq MA,Kulandhasamy M,Kant K,Pareek V

更新日期：2020-12-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：:Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progr...

journal_title：Medical hypotheses

authors： Ali ZA,El-Mallakh RS

更新日期：2020-11-01 00:00:00

abstract：:Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the largest current health challenge for the society. At the moment, the therapeutic strategies to deal with this disease are only supportive. It is well known that zinc (Zn) possesses a variety of dir...

journal_title：Medical hypotheses

authors： Kumar A,Kubota Y,Chernov M,Kasuya H

更新日期：2020-11-01 00:00:00

abstract：:The menstrual cycle appears to have evolved in humans and some other species to improve reproductive efficiency by enabling progesterone production without the presence of the fetus. This phenomenon is termed spontaneous decidualization. Repeated menstruation is produced in modern women because of better general healt...

journal_title：Medical hypotheses

authors： Goldstuck ND

更新日期：2020-11-01 00:00:00

abstract：:Burnout is a state of physical or mental collapse caused by overwork or stress. Burnout during residency training has gained significant attention secondary to concerns regarding job performance and patient care. The new COVID-19 pandemic has raised public health problems around the world and required a reorganization...

journal_title：Medical hypotheses

authors： Dimitriu MCT,Pantea-Stoian A,Smaranda AC,Nica AA,Carap AC,Constantin VD,Davitoiu AM,Cirstoveanu C,Bacalbasa N,Bratu OG,Jacota-Alexe F,Badiu CD,Smarandache CG,Socea B

更新日期：2020-11-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:In the present study, we used the potential of bioinformatics and computational analysis to predict the existence and biological relevance of zinc finger (ZF) motifs in heamagglutinin (HA) protein of Avian Influenza (AI) virus. Sequence data of Avian Influenza (AI) viruses were retrieved from accessible databases (Gen...

journal_title：Medical hypotheses

authors： Muraina IA,Meseko CA,Fasina FO

更新日期：2020-11-01 00:00:00

abstract：:Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Speci...

journal_title：Medical hypotheses

authors： Balaji A,Bhuvaneswari S,Kumar DN

更新日期：2020-11-01 00:00:00

abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...

journal_title：Medical hypotheses

authors： Ma S,Lu Q,Hu H,Du XJ

更新日期：2020-11-01 00:00:00

abstract：:Concerning the damage to back muscles and posterior ligament complex (PLC) by posterior open approach for lumbar spinal stenosis (LSS), the oblique lateral intervertebral fusion (OLIF) is pretty popular nowadays. However, oblique lateral approach has obvious drawbacks, which are limited vision and operative scope for ...

journal_title：Medical hypotheses

authors： Du C,Wu T,Mao T,Jia F,Hai B,Zhu B,Liu X

更新日期：2020-11-01 00:00:00

abstract：:Shear wave sonoelastography is a valuable additional technique in differentiation between benign and malignant breast lesions. In this paper, a hypothesis of the potential role of this additional ultrasound technique as a very useful tool in differentiation of a medullary breast cancer subtype is proposed. Medullary b...

journal_title：Medical hypotheses

authors： Biondić Špoljar I,Ivanac G,Radović N,Divjak E,Brkljačić B

更新日期：2020-11-01 00:00:00

abstract：:The understanding of the renin-angiotensin system (RAS) has significantly expanded over the last two decades. The elucidation of angiotensin-converting enzyme 2 (ACE2) that converts angiotensin (Ang) II into Ang (1-7) led to the discovery of the cardio-protective axis of the RAS. In addition, novel components of the s...

journal_title：Medical hypotheses

authors： Jha S,Speth RC,Macheroux P

更新日期：2020-11-01 00:00:00

abstract：:Mainstream researchers explain the etiology of SIDS with the cardiorespiratory paradigm. This has been the focus of intense study for many decades without providing consistent supporting data to link CNS findings to epidemiological risk factors or to the usual clinicopathological findings. Despite this, and the appare...

journal_title：Medical hypotheses

authors： Goldwater PN

更新日期：2020-11-01 00:00:00

abstract：HYPOTHESIS:The delayed lung damage after SARS-CoV-2 infection may be caused by an autoimmune response to ACE2 induced by forced presentation of the ACE2 protein in a complex with CoV Spike in Fc Receptor positive Antigen Presenting Cells in the lung. The likelihood that this hypothesis is valid is low, but it is easily...

journal_title：Medical hypotheses

authors： Townsend A

更新日期：2020-11-01 00:00:00

abstract：:It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/H...

journal_title：Medical hypotheses

authors： Bhattacharyya D

更新日期：2020-11-01 00:00:00

abstract：:Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine foramen. Over l...

journal_title：Medical hypotheses

authors： Kairo AK,Kumar R,Sharma SC

更新日期：2020-11-01 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming incr...

journal_title：Medical hypotheses

authors： Tao H,Bai J,Zhang W,Zheng K,Guan P,Ge G,Li M,Geng D

更新日期：2020-11-01 00:00:00

abstract：:Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...

journal_title：Medical hypotheses

authors： Avcilar H,Eken A

更新日期：2020-11-01 00:00:00

abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

journal_title：Medical hypotheses

authors： Du W,Han W,Dong J

更新日期：2020-11-01 00:00:00

abstract：:Chronic otitis media with cholesteatoma can cause erosion of the dense labyrinthine bone overlying the inner ear organs, and this labyrinthine fistula allows pressure or mass-induced motion of the underlying perilymphatic and endolymphatic compartment, evoking vestibular symptoms. While the mechanism of a positive fis...

journal_title：Medical hypotheses

authors： Jeong H,Lee DH,Shin JE,Kim CH

更新日期：2020-11-01 00:00:00

abstract：:(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence hig...

journal_title：Medical hypotheses

authors： Demongeot J,Seligmann H

更新日期：2020-11-01 00:00:00

abstract：:The contribution of various modes of transmission of SARS-CoV-2 has been the subject of recent intensive debate. The predominant route of the viral transmission is via exhaled droplets of different sizes which can be inhaled by nearby exposed individuals or deposited on peoples and surfaces. Touching contaminated surf...

journal_title：Medical hypotheses

authors： Przekwas A,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated w...

journal_title：Medical hypotheses

authors： Räisänen IT,Umeizudike KA,Pärnänen P,Heikkilä P,Tervahartiala T,Nwhator SO,Grigoriadis A,Sakellari D,Sorsa T

更新日期：2020-11-01 00:00:00

abstract：:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocul...

journal_title：Medical hypotheses

authors： Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

更新日期：2020-11-01 00:00:00

abstract：:There must be pathophysiological reason why "cold" viruses like SARS-CoV-2 show proclivity to nasal cavity, oral cavity, pharyngeal cavity and upper airways which have lower temperature than core body temperature. Henceforth, facemasks' "therapeutic" role against SARS-CoV-2 must be explored because personal "therapeut...

journal_title：Medical hypotheses

authors： Gupta D

更新日期：2020-10-01 00:00:00

abstract：:Oxidative stress-mediated neurodegeneration is responsible for 12% mortality around the globe. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most prevalent neurodegenerative diseases, associated with modulation of acetylcholine levels and amyloid beta accumulation & dopamine level and alpha-synuclein o...

journal_title：Medical hypotheses

authors： Krishnaswamy VKD,Alugoju P,Periyasamy L

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...

journal_title：Medical hypotheses

authors： Poonsiri J,van Putten SWE,Ausma AT,Geertzen JHB,Dijkstra PU,Dekker R

更新日期：2020-10-01 00:00:00

abstract：:SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatm...

journal_title：Medical hypotheses

authors： Abeygunasekera A,Jayasinghe S

更新日期：2020-10-01 00:00:00

abstract：:Prepulse inhibition (PPI) of acoustic startle reflex is a measure of sensorimotor gating that may reflect the biological processes underlying gaiting impairments in schizophrenia. Although PPI is clinically useful, why PPI is inhibited in schizophrenia is largely unknown. Prepulse inhibition is mediated by M2-like mus...

journal_title：Medical hypotheses

authors： Sato K

更新日期：2020-10-01 00:00:00