Abstract：
:Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients' lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Ali ZA,El-Mallakh RSdoi
10.1016/j.mehy.2020.109947subject
Has Abstractpub_date
2020-11-01 00:00:00pages
109947eissn
0306-9877issn
1532-2777pii
S0306-9877(20)31293-7journal_volume
144pub_type
杂志文章abstract：:An association between Alzheimer's Disease (AD) and low CSF and serum vitamin B12 (B12) has recently been described (1, 2, 3). This is apparently independent of nutritional intake (4). It has been suggested that such patients may exhibit an atypical form of cobalamin deficiency (3, 4). It is therefore proposed that th...
journal_title：Medical hypotheses
pub_type： 杂志文章
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abstract：:Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG® a polymer based contraceptive device has b...
journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.05.026
更新日期：2009-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.031
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
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doi：10.1016/j.mehy.2020.109737
更新日期：2020-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90057-w
更新日期：1993-08-01 00:00:00
abstract：:Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is primarily caused by mutations in the Methyl CpG binding prote...
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doi：10.1016/j.mehy.2010.09.015
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1252
更新日期：2001-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.12.021
更新日期：2012-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109869
更新日期：2020-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90277-8
更新日期：1998-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.058
更新日期：2009-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1176
更新日期：2001-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.11.022
更新日期：2013-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00150-6
更新日期：2003-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.05.014
更新日期：2018-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.02.032
更新日期：2018-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.01.039
更新日期：2012-05-01 00:00:00
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journal_title：Medical hypotheses
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doi：10.1016/j.mehy.2013.03.023
更新日期：2013-06-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2017-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
abstract：:September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...
journal_title：Medical hypotheses
pub_type： 传,社论,历史文章
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更新日期：2009-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.04.030
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0306-9877(93)90069-3
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.11.007
更新日期：2013-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.03.042
更新日期：2013-08-01 00:00:00
