Abstract:
:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocular transmission of SRS-CoV-2. Hence, it is hypothesized that topical ocular prophylaxis using biocompatible polymers with reported in-vitro and in-vivo evidence of ACE inhibition and antiviral activity appears to be a promising strategy for preventing ocular transmission of Covid-19 to healthcare workers. They are capable of binding to ACE-2 receptors which may provide highly potential trails to block virus entry to host cells. Further biopolymers imparting antiviral activities greatly improve their protective performance. They not only provide prolong protection but also are safe for long-term use. This article discusses the description of structural and functional attributes of ACE-2 to identify appropriate polymer with better binding affinity. Furthermore, potential polymers with appropriate concentration are suggested for evaluation through a hypothesis to consider them for Covid-19 implication.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath Gdoi
10.1016/j.mehy.2020.110288subject
Has Abstractpub_date
2020-11-01 00:00:00pages
110288eissn
0306-9877issn
1532-2777pii
S0306-9877(20)31764-3journal_volume
144pub_type
杂志文章abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...
journal_title:Medical hypotheses
pub_type: 杂志文章
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abstract::In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...
journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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更新日期:2020-08-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.04.023
更新日期:2011-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.08.027
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90256-2
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pub_type: 历史文章,杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.041
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/0306-9877(92)90079-r
更新日期:1992-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.mehy.2008.11.049
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90011-e
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pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.029
更新日期:2012-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.05.023
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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