Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19.

Abstract:

:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocular transmission of SRS-CoV-2. Hence, it is hypothesized that topical ocular prophylaxis using biocompatible polymers with reported in-vitro and in-vivo evidence of ACE inhibition and antiviral activity appears to be a promising strategy for preventing ocular transmission of Covid-19 to healthcare workers. They are capable of binding to ACE-2 receptors which may provide highly potential trails to block virus entry to host cells. Further biopolymers imparting antiviral activities greatly improve their protective performance. They not only provide prolong protection but also are safe for long-term use. This article discusses the description of structural and functional attributes of ACE-2 to identify appropriate polymer with better binding affinity. Furthermore, potential polymers with appropriate concentration are suggested for evaluation through a hypothesis to consider them for Covid-19 implication.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

doi

10.1016/j.mehy.2020.110288

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

110288

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(20)31764-3

journal_volume

144

pub_type

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