The broader autism phenotype constellations-disability matrix paradigm: Theoretical model for autism and the broader autism phenotype.

abstract：:Pulmonary congestion is a hallmark feature of heart failure and is a major reason for hospital admissions in this patient population. Heart failure patients often demonstrate restrictive and obstructive pulmonary function abnormalities; however, the mechanisms of these changes remain controversial. It has been suggest...

journal_title：Medical hypotheses

authors： Ceridon M,Wanner A,Johnson BD

更新日期：2009-09-01 00:00:00

abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2001-02-01 00:00:00

abstract：:Alzheimer's disease (AD) includes etiologically heterogeneous disorders characterized by senile or presenile dementia, extracellular amyloid protein aggregations containing an insoluble amyloid precursor protein derivative, and intracytoplasmic tau protein aggregations. Recent studies also show excess neuronal aneuplo...

journal_title：Medical hypotheses

authors： Swerdlow RH,Khan SM

更新日期：2004-01-01 00:00:00

abstract：:The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens bind to the regions of DNA to which steroid hormones bind and cause the deletion of genes in these regions. 2. The deletion of these genes may be responsible for a reduced number of ribosomes bound to the endoplasmic reticulum. 3. ...

journal_title：Medical hypotheses

authors： Money-Kyrle AF

更新日期：1977-07-01 00:00:00

abstract：:Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interpla...

journal_title：Medical hypotheses

authors： Fedorko ME

更新日期：1999-08-01 00:00:00

abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...

journal_title：Medical hypotheses

authors： Wee AKH

更新日期：2021-01-01 00:00:00

abstract：:Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still ...

journal_title：Medical hypotheses

authors： Nathan P

更新日期：2000-06-01 00:00:00

abstract：:In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. Genetic, viral, and endocrine factors interact during development to produce the syndrome. Many of the deficiencies of AKR mice are associated with gene action in chromosome 17, at or near the major histocompa...

journal_title：Medical hypotheses

authors： Vriend J

更新日期：1976-11-01 00:00:00

abstract：:For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attr...

journal_title：Medical hypotheses

authors： Mainardi P,Albano C

更新日期：2008-01-01 00:00:00

abstract：:Acute viral infection is characterised by high-level replication before prompt decline of viraemia and, commonly, viral clearance. This kinetic pattern is generally held to be due to immune control. However, infection with some viruses, notably hepatitis C (HCV), hepatitis B (HBV) and the human immunodeficiency virus ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...

journal_title：Medical hypotheses

authors： Schrier E,Dijkstra PU,Zeebregts CJ,Wolff AP,Geertzen JHB

更新日期：2018-12-01 00:00:00

abstract：:Parkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson's disease usi...

journal_title：Medical hypotheses

authors： Yaman O,Ertam F,Tuncer T

更新日期：2020-02-01 00:00:00

abstract：:Dizziness is one of the most common hemodialysis-associated symptoms, and has been thought to be caused by cerebral edema or intravascular hypovolemia. However, the possibility of a peripheral vestibular disturbance due to hemodialysis has not been addressed as a cause of hemodialysis-associated dizziness. In the pres...

journal_title：Medical hypotheses

authors： Kim CH,Shin JE,Park JH

更新日期：2019-08-01 00:00:00

abstract：:Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature. ...

journal_title：Medical hypotheses

authors： Yabrov A

更新日期：1986-03-01 00:00:00

abstract：:Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

journal_title：Medical hypotheses

authors： Biran H,Ariel I,De Groot N,Hochberg A

更新日期：1994-08-01 00:00:00

abstract：:The biophysical processes during electroconvulsive therapy (ECT) are discussed. The multilayer head structure causes a shunting and spreading of the major portions of the current all over the extracranial tissues. The final effect is that only a small percentage of the injected current passes into the brain. The secon...

journal_title：Medical hypotheses

authors： Zyss T

更新日期：1994-08-01 00:00:00

abstract：:The most important obstacle for preventing hypertension is the belief that systemic hypertension has no identifiable cause. This belief, hiding the main offender, sodium chloride, causes too much time wasting for combating against hypertension. Accepting that sodium chloride is a drug and re-evaluating the situation a...

journal_title：Medical hypotheses

authors： Tekol Y

更新日期：2006-01-01 00:00:00

abstract：:The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and ...

journal_title：Medical hypotheses

authors： Venkatesh R,Reddy NG,Chhablani J

更新日期：2021-01-01 00:00:00

abstract：:Several disorders or abnormalities observed in medicine and psychology are not explicable (or not fully explicable) by genetics and environmental influences, either alone or together. These include phobias and philias observed in early infancy, unusual play in childhood, homosexuality, gender identity disorder, a chil...

journal_title：Medical hypotheses

authors： Stevenson I

更新日期：2000-04-01 00:00:00

abstract：:We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extr...

journal_title：Medical hypotheses

authors： Hajek D,Kolar P,Maini PK,Starha P

更新日期：2005-01-01 00:00:00

abstract：:The author reviews the criticism aimed at medical education and suggests that its shortcomings could be corrected by modifying the curriculum so that irrelevant material is eliminated and replaced in part with the humanities. ...

journal_title：Medical hypotheses

authors： Prioreschi P

更新日期：1980-05-01 00:00:00

abstract：:The affected individual of hair loss demands help, because hair is viewed as a sign of youth and good health. Nowadays treatment of alopecia includes drug therapy and hair transplantation. Some drugs may promote hair growth, at least temporarily, but the treatment is effective only in milder alopecia, instead of exten...

journal_title：Medical hypotheses

authors： Zhao J,Liu LQ,Wang YJ,Yang W,Geng WX,Wei J,Li LW,Chen FL

更新日期：2008-01-01 00:00:00

abstract：:Homeostasis, or the maintenance of constant internal environment in the organism, is disrupted by injury. In this case, pathological defence reactions such as inflammation and healing take place in order to restore it. They succeed if etiological harmful factors are eliminated. In the opposite case, constant injury le...

journal_title：Medical hypotheses

authors： Beranek JT

更新日期：1991-10-01 00:00:00

abstract：:Limbic associated pelvic pain is a proposed pathophysiology designed to explain features commonly encountered in patients with chronic pelvic pain, including the presence of multiple pain diagnoses, the frequency of previous abuse, the minimal or discordant pathologic changes of the involved organs, the paradoxical ef...

journal_title：Medical hypotheses

authors： Fenton BW

更新日期：2007-01-01 00:00:00

abstract：:The dissimilarities in spin-lattice relaxation time (T1) of water proton from one tumor to the other is due to the yield of hypoxic fraction in the tumor. The yield of higher relaxation time (T1) in the KHT tumor compared to the RIF-1 tumor as a function of growth is due to the hypoxic fraction of the tumor. The hypox...

journal_title：Medical hypotheses

authors： Akber SF

更新日期：1992-01-01 00:00:00

abstract：:Although frequently encountered, no available consensus about the association between skeletal abnormalities and skin pigmentation. Several syndromes are characterized by the presence of skin pigmentation in association with skeletal disorders like neurofibroamtosis 1, McCune-Albright Syndrome, Jaffe-Campanacci Syndro...

journal_title：Medical hypotheses

authors： Abdel-Wanis ME,Kawahara N

更新日期：2003-11-01 00:00:00

abstract：:A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...

journal_title：Medical hypotheses

authors： Gjorgov AN

更新日期：1978-03-01 00:00:00

abstract：:Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in respon...

journal_title：Medical hypotheses

authors： Pienta KJ,Ward WS

更新日期：1994-01-01 00:00:00

abstract：:In idiopathic scoliosis the convexity of the thoracic curve of the vertebral column is most commonly directed toward the right side. The right lung is normally larger than the left lung. This asymmetry acting through chest wall movement is hypothesized to exert rotatory forces on the vertebral column. The result, in p...

journal_title：Medical hypotheses

authors： Del Bigio MR

更新日期：1989-04-01 00:00:00

abstract：:Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CTCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy b...

journal_title：Medical hypotheses

authors： Ren C,Chen H,Han C,Jin G,Wang D,Wang D,Tang D

更新日期：2013-06-01 00:00:00