Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?

abstract：:Diabetes is a global public health challenge that imposes heavy burdens on communities and individuals. Metformin, the first-line medication for diabetes, has the superiority of reducing risk of macrovascular diseases, all-cause mortality and even possibly cancers. Recent observational studies, however, have demonstra...

journal_title：Medical hypotheses

authors： Xu L,Huang Z,He X,Wan X,Fang D,Li Y

更新日期：2013-08-01 00:00:00

abstract：:The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be hig...

journal_title：Medical hypotheses

authors： Norris V

更新日期：2011-05-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...

journal_title：Medical hypotheses

authors： Arendt T,Mönig H,Stüber E,Katsoulis S,Fölsch UR

更新日期：2000-04-01 00:00:00

abstract：:September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...

journal_title：Medical hypotheses

authors： Notturno MA

更新日期：2009-12-01 00:00:00

abstract：:It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent meta...

journal_title：Medical hypotheses

authors： Baldwin GS

更新日期：1992-05-01 00:00:00

abstract：:In literature, the cerebellum is given a substantial role in cognitive processes, in addition to traditional views on cerebellar function of regulating motor behaviour. The phenomenon of cerebellar damage causing impairments in memory and executive functioning was observed in various cerebellar disorders. Cerebellar c...

journal_title：Medical hypotheses

authors： Wijnia JW,Goossensen A

更新日期：2010-08-01 00:00:00

abstract：:One area of relative agreement in schizophrenic research is that there is grey matter volume deficit in various cortical areas associated with this illness. One theory attempting to explain this involves an exaggerated action of the normal CNS pruning process. Various aspects of this process were discussed along with ...

journal_title：Medical hypotheses

authors： Rosenthal R

更新日期：2011-07-01 00:00:00

abstract：:This article reviews the biochemical and physiological observations underpinning the synergism between ghrelin and ghrelin agonists with exercise, especially progressive resistance training that has been shown to increase muscle mass. The synergy of ghrelin agonists and physical exercise could be beneficial in conditi...

journal_title：Medical hypotheses

authors： Fuoco D,Kilgour RD,Vigano A

更新日期：2015-12-01 00:00:00

abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...

journal_title：Medical hypotheses

authors： White MW

更新日期：1992-12-01 00:00:00

abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...

journal_title：Medical hypotheses

authors： Stumvoll M,Meyer C,Mitrakou A,Gerich JE

更新日期：1999-05-01 00:00:00

abstract：:In view of the limited success of available treatment modalities for metastatic tumor, alternative and complementary strategies need to be developed. Oncolytic viruses are capable of selective replication in malignant cells and therefore offer levels of potency and specificity that are potentially far higher than conv...

journal_title：Medical hypotheses

authors： Deng W,Jia J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...

journal_title：Medical hypotheses

authors： Tilman V

更新日期：2016-01-01 00:00:00

abstract：:Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA),...

journal_title：Medical hypotheses

authors： Fischer KM

更新日期：1998-09-01 00:00:00

abstract：:Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of ...

journal_title：Medical hypotheses

authors： Wang JZ,Li L,Pan LL,Chen JH

更新日期：2015-11-01 00:00:00

abstract：:Both epidemiological and experimental studies have shown that impaired growth in utero due to maternal malnutrition, resulting in low birth weight, is associated with a high incidence of glucose intolerance, insulin resistance, and type 2 diabetes in adult life. Maternal malnutrition is a worldwide problem and unavoid...

journal_title：Medical hypotheses

authors： Ende N,Reddi AS

更新日期：2006-01-01 00:00:00

abstract：:Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...

journal_title：Medical hypotheses

authors： Holmqvist OH

更新日期：2000-03-01 00:00:00

abstract：:The malignant melanoma may display extremely variable forms of development, from clinical forms with a lethal course to the unforeseeable situations of spontaneous cures. The basic immunotherapeutic procedures, as well as hypotheses regarding the mechanisms involved in courses towards spontaneous regressions, are pres...

journal_title：Medical hypotheses

authors： Motofei IG

更新日期：1996-08-01 00:00:00

abstract：:Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...

journal_title：Medical hypotheses

authors： Garcia-Garcia A

更新日期：2009-04-01 00:00:00

abstract：:Mood disturbances and depression are supposed to have a negative impact on patients' outcome in malignant tumour disease. On the other hand, poor prognosis in cancer patients is associated with chronic immune challenge which is paralleled by enhanced degradation of the essential amino acid tryptophan and thus decrease...

journal_title：Medical hypotheses

authors： Murr C,Widner B,Sperner-Unterweger B,Ledochowski M,Schubert C,Fuchs D

更新日期：2000-08-01 00:00:00

abstract：:We describe here a new technique for analyzing human growth curves using a first order kinetic representation. Plotting in ([h infinity-ht)/h infinity] vs time (where h infinity and ht represent the final and instantaneous heights) transforms growth curves into 3 linear phases and 2 interphases. These growth parameter...

journal_title：Medical hypotheses

authors： Schreiber G,Baron B

更新日期：1985-02-01 00:00:00

abstract：:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...

journal_title：Medical hypotheses

authors： Pallotti C,Pettazzoni P,Slawomirski MR

更新日期：1995-05-01 00:00:00

abstract：:A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues. To this aim, structural differences between eukaryotic and prokaryotic enzyme proteins involved in life processes are widely exploited. The membrane-bound enzyme complex ATP s...

journal_title：Medical hypotheses

authors： Nesci S,Ventrella V,Trombetti F,Pirini M,Pagliarani A

更新日期：2014-08-01 00:00:00

abstract：:In orthognathic surgery, many serious medical disputes and postsurgical dissatisfactions are not caused by the doctors' reasons, but due to the patients' psychological problems. These adverse events obsess not only surgeons, but also patients to a great extent. An effective method is expected to screen patients for or...

journal_title：Medical hypotheses

authors： Yu D,Fang B,Wang F,Wang X,Zhang W,Dai J,Shen SG

更新日期：2013-08-01 00:00:00

abstract：:The results described in this paper partially agree with the hypothesis that mesenteric lymph nodes (MLN) of depleted growing rats recover their antigen specific determinants after the oral administration of 20% casein for 5-9 days following the time course of antigen dependent changes observed in virgin lymph nodes. ...

journal_title：Medical hypotheses

authors： Langini SH,López MC,Slobodianik NH,Sanahuja JC,Rio ME,Roux ME

更新日期：1987-08-01 00:00:00

abstract：:Exacerbation of certain medical conditions during specific phases of the menstrual cycle has long been recognized. Mechanisms of the cyclic variations are poorly understood, but are often attributed to fluctuations in reproductive hormones. We hypothesize that normal variations in autonomic balance during the menstrua...

journal_title：Medical hypotheses

authors： Lee PY,Bazar KA,Yun AJ

更新日期：2004-01-01 00:00:00

abstract：:This hypothesis named Salerian Addictive Potential (SAP) suggests that the addictive potency of any substance may be calculated with an algebraic equation of A=E/T(max)xt(1/2), where A is the addictive potency, E represents the euphoric potency, T(max) is the time to reach peak plasma concentration, and t(1/2) is the ...

journal_title：Medical hypotheses

authors： Salerian AJ

更新日期：2010-06-01 00:00:00

abstract：:The hypothesis proposed is that restoration of functional capacity of denervated diaphragm may be achieved by reinervating it with vagus nerve. Following trauma, carcinomatose infiltration, and/or large thoracic surgery and neck surgery, phrenic nerve is frequently injured. Reinervation even in the most favourable con...

journal_title：Medical hypotheses

authors： Pavlovic D,Wendt M

更新日期：2003-03-01 00:00:00

abstract：:Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (C...

journal_title：Medical hypotheses

authors： Mani Mishra P,Uversky VN,Nandi CK

更新日期：2020-04-24 00:00:00

abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...

journal_title：Medical hypotheses

authors： Lu DY,Chen XL,Ding J

更新日期：2007-01-01 00:00:00