Abstract：
:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. In turn, HIF-1α regulates the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF). Ascribed to abnormal characteristics of tumor angiogenic networks, antiangiogenic therapy approaches can even worsen the hypoxic condition and can create cancer cells with stemness features. Hence oxygen delivery via perfluorocarbon (PFC) to hypoxic sites seems to result in unstable HIF expression and consequent inactivation of angiogenesis cascade and metastasis and therefore, inhibition of cancer cells stemness.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Farhadi P,Yarani R,Kiani S,Mansouri Kdoi
10.1016/j.mehy.2020.110357subject
Has Abstractpub_date
2021-01-01 00:00:00pages
110357eissn
0306-9877issn
1532-2777pii
S0306-9877(20)33248-5journal_volume
146pub_type
杂志文章abstract：:Mucous membrane pemphigoid (MMP) is a subtype of autoimmune subepidermal blistering diseases characterized by autoantibodies to structural components of the hemidesmosome primarily affecting mucous membranes. Inflammation-related progressive scarring can lead to serious complications, including blindness, and the dise...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.06.021
更新日期：2015-10-01 00:00:00
abstract：:Review of 18th and 19th century psychiatric therapies raises the possibility that several may have altered the activity of vasopressin or Na-K-ATPase. Bleeding, whirling, nausea created by medicines, and vagus nerve stimulation by application of electricity through the skin all perturb the hypothalamic hormone, argini...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/j.mehy.2003.10.007
更新日期：2004-01-01 00:00:00
abstract：:The possibility that Hematopoiesis is under CNS control has been discussed in the literature; but never been conclusively proved at the molecular level. Evidence in the form of antigenic similarity between murine brain and the Stem Cell, and the decline in the number of Stem Cells following the lesioning of the Locus ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90010-2
更新日期：1988-12-01 00:00:00
abstract：:Cystic fibrosis-related diabetes (CFRD) has emerged in the last thirty years as a critical complication of cystic fibrosis (CF) and is present in about 15% of CF patients with increasing prevalence with age approaching 50 for over 30 year olds. The mechanism of diabetes development in this group of patients is not ver...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.058
更新日期：2009-01-01 00:00:00
abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.09.041
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:There is widespread loss of acetylcholine and other neurotransmitters in Alzheimer's disease and vascular dementia. It has generally been assumed that death of neurons causes neurotransmitter loss, but alternatively neurotransmitter depletion itself may at least contribute to neurodegeneration. PRESENTATION...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.043
更新日期：2006-01-01 00:00:00
abstract：:The precise role of erythrophagocytosis in sickle cell disease is not known. Using hematological data from three studies and 791 subjects comprising of eight epidemiological groups, we found a strong statistical support for the hypothesis that erythrophagocytosis is increased in sickle cell trait, that neutrophils and...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.09.044
更新日期：2007-01-01 00:00:00
abstract：:The natural tibiofemoral joint (TFJ) functions according to the asymmetrical joint surfaces and the rolling-gliding mechanism. In the sagittal section, the human TFG is the tibial plateau on the medial concave side and curved on the lateral convex. With the asymmetrical joint surfaces, the flexion of the knee consists...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.04.015
更新日期：2014-09-01 00:00:00
abstract：:Organogenesis is the result of cell allocation followed by cell differentiation, and the processes involved are still to be elucidated. Present-day teaching suggests that the cytoplasmic membrane, the extracellular matrix and the cytoskeleton, in combination, are responsible, but the literature also suggests that othe...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90249-2
更新日期：1996-03-01 00:00:00
abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109754
更新日期：2020-09-01 00:00:00
abstract：:About 25-50% of children and adolescents with attention-deficit hyperactivity disorder (ADHD) experience sleep problems. An appropriate assessment and treatment of such problems might improve the quality of life in such patients and reduce both the severity of ADHD and the impairment it causes. According to data in th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.04.020
更新日期：2012-08-01 00:00:00
abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0752
更新日期：1999-09-01 00:00:00
abstract：:Incidental pituitary adenoma is the common finding during brain imaging. According to multistep model of pituitary tumourigenesis genetic alterations provide the initiating event that transforms cells while hormones play a role in promoting cell proliferation. Development of pituitary adenoma in a case of excessive hy...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.11.044
更新日期：2007-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.11.030
更新日期：2016-01-01 00:00:00
abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90194-1
更新日期：1989-07-01 00:00:00
abstract：:The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0663
更新日期：1999-05-01 00:00:00
abstract：:The exact aetiology of mitral valve prolapse (MVP) is unknown, although this is the most common cardiac valvular abnormality currently detected. MVP has high incidence in young individuals, particularly during the second and third decades. These individuals are usually of a slender body habitus indicating higher rates...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0016
更新日期：2000-02-01 00:00:00
abstract：:The persistent use of different forms of nicotine replacement therapy (NRT) is an under-investigated issue in medical research. While the data concerning the proportion of long-term users in the population of total NRT users seems reassuring at first glance, we must recognize that the small relative numbers (proportio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.08.045
更新日期：2011-12-01 00:00:00
abstract：:Chronic Fatigue Syndrome is a physiological state in which the patient feels high levels of fatigue without an obvious organic cause, which affects around 1 in 400 people in the developed world. A wide range of causes have been suggested, including immune or hormonal dysfunction, viral or bacterial infection, and psyc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.02.022
更新日期：2008-10-01 00:00:00
abstract：:We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.05.007
更新日期：2019-07-01 00:00:00
abstract：:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90152-6
更新日期：1987-06-01 00:00:00
abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1452
更新日期：2002-01-01 00:00:00
abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90060-8
更新日期：1981-09-01 00:00:00
abstract：:Plasticity of adult cells has been identified in several post-natal tissues in the past few years and has attracted special attention in regenerative medicine. Skin is the biggest organ in the body. Adult skin consists of epidermis, dermis and appendages such as hairs and glands which are linked to the epidermis but p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.022
更新日期：2004-01-01 00:00:00
abstract：:In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90261-v
更新日期：1991-10-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a common and underdiagnosed medical disorder. OSA is associated with the symptoms of excessive daytime sleepiness (EDS). These patients typically follow a sedentary lifestyle, and sedentary behavior is related to impaired fluid dynamics in the lower body, particularly the legs. In a su...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：:HIV may induce subclinical neuroendocrine dysfunctions in some seropositive patients and these dysfunctions may be one of the co-factors that determine the pathogenesis of AIDS. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90090-4
更新日期：1988-09-01 00:00:00
abstract：:The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hyp...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.01.014
更新日期：2018-03-01 00:00:00
abstract：:The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90085-s
更新日期：1990-09-01 00:00:00
abstract：:The data of literature are discordant about the role of mast cells in different types of neoplasms. In this paper the authors propose the hypothesis that tumor-associated mast cells may switch to different polarization states, conditioning the immunogenic capacities of the different neoplasms. Anti-inflammatory polari...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109281
更新日期：2019-10-01 00:00:00
