Abstract:
:The data of literature are discordant about the role of mast cells in different types of neoplasms. In this paper the authors propose the hypothesis that tumor-associated mast cells may switch to different polarization states, conditioning the immunogenic capacities of the different neoplasms. Anti-inflammatory polarized mast cells should express cytokines such as interleukin-10 (IL-10) and then mast cells number should be inversely related to the intensity of inflammatory infiltrate. On the contrary, when mast cells do not express anti-inflammatory cytokines their number should be directly related to the intensity of the inflammatory infiltrate. In this paper we briefly argue around feasible approaches, based on the retrospective studies of tumor tissue samples from neoplasms considered "immunologically hot" and neoplasms considered "immunologically cold", through immunohistochemistry and immunofluorescence techniques (confocal microscopy). The establishment of the actual existence of a polarization interchange of mast cells, could lead to a new vision in prognostic terms, useful to contrive new approaches in immunotherapy of tumors.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Presta I,Donato A,Zaffino P,Spadea MF,Mancuso T,Malara N,Chiefari E,Donato Gdoi
10.1016/j.mehy.2019.109281subject
Has Abstractpub_date
2019-10-01 00:00:00pages
109281eissn
0306-9877issn
1532-2777pii
S0306-9877(19)30359-7journal_volume
131pub_type
杂志文章abstract::Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...
journal_title:Medical hypotheses
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