Abstract:
:It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and differentiation during hominid evolution, particularly of the regions liable to Alzheimer pathology, and further occur in Down syndrome [suggesting that genes on chromosome 21 are included in G(x)]. If genes which promoted human brain evolution contribute to the value of G(x), a better understanding of the genomic events which promoted this evolution, using molecular biological techniques, should elucidate the genetic basis of Alzheimer's disease, and vice versa.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Rapoport SIdoi
10.1016/0306-9877(89)90185-0subject
Has Abstractpub_date
1989-07-01 00:00:00pages
147-50issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(89)90185-0journal_volume
29pub_type
杂志文章abstract::The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...
journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 社论
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pub_type: 杂志文章
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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journal_title:Medical hypotheses
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