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For ischemic brain damage, is preclinical evidence of neuroprotection by presynaptic blockade of glutamate release enough?

Abstract：

:Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimate quantitatively the current state of the knowledge concerning the neuroprotective effect of drugs inhibiting glutamate release and to attempt to resolve the apparent controversy in relation to the neuroprotective properties of these drugs, a meta-analysis was performed. It identified a significant difference between drugs blocking glutamate release and controls. Therefore, we hypothesize that inhibition of presynaptic glutamate release could be a major goal in neuroprotection when ischemic brain damage is present and that meta-analysia could be a useful tool for preclinical studies,

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

doi

10.1054/mehy.1998.0831

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

77-9

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306987798908313

journal_volume

54

pub_type

杂志文章

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