Abstract:
:Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods present disadvantages in clinical practice. Studies have shown that patients with glaucoma often suffer negative emotion like anxiety and depression which is related to abnormal or reduced amygdala. Moreover, selective reduction of fMRI responses to transient achromatic stimuli in the superficial layer of the superior colliculus was found in the early glaucoma patients. By summarizing previous studies, we developed a hypothesis: superior colliculus-pulvinar-amygdala subcortical visual pathway may be involved in the incidence or progression of glaucoma. Validating this hypothesis would further clarify the mechanism of glaucoma and lead to the development of a more sensitive method for making an early diagnosis of glaucoma.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sun Y,Huang W,Li F,Li H,Wang L,Huang Y,Zhang Xdoi
10.1016/j.mehy.2018.12.020subject
Has Abstractpub_date
2019-02-01 00:00:00pages
47-49eissn
0306-9877issn
1532-2777pii
S0306-9877(18)31053-3journal_volume
123pub_type
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