Abstract:
:Neurofibromatosis 1 is a common heritable disorder. The gene causing neurofibromatosis 1 had been recognized and the protein encoded by this gene, neurofibromin, was supposed to play a role in development of various tissues. Neurofibromin was found to have GTP-ase (GAP) domain against small p21 ras. IQGAP1 is another human ras-specific GAP that was found to have calmodulin-binding motifs. Spinal deformities in cases of neurofibromatosis 1 are generally classified into dystrophic and non-dystrophic. Aetiologies of both types are still unknown. We hypothesize that muscle pathology could be the initiating factor for non-dystrophic curves due to neurofibromin deficiency and/or increase of the level of IQGAP. Dystrophic curves might begin as a developmental error due to neurofibromin deficiency in bone. Melatonin deficiency, increased serotonin level with disturbed melatonin-serotonin interactions and calmodulin antagonism by increased IQGAP1 may be responsible for progression of both types of spinal deformities in neurofibromatosis 1.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Abdel-Wanis ME,Kawahara Ndoi
10.1054/mehy.2000.1232keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
400-4issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(00)91232-5journal_volume
56pub_type
杂志文章abstract::Microbial resistance to conventional as well as newly introduced drugs is a hallmark feature of several infectious diseases, notably tuberculosis. It is hypothesized that the greater the selective pressure exerted by increasingly potent drugs, the more rapidly is an organism able to adapt to a drug-containing environm...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90215-5
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pub_type: 临床试验,杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.01.034
更新日期:2007-01-01 00:00:00
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更新日期:2012-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.10.008
更新日期:2014-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.04.015
更新日期:2014-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.07.007
更新日期:2017-09-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.005
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1987-07-01 00:00:00