Abstract:
:p27(Kip1) (here after referred to as p27) is a member of a family of cyclin-dependent kinase inhibitors that control cell cycle. There is a considerable evidence that p27 plays a pivotal role in multiple foundational cellular processes, including cell proliferation, cell differentiation, and apoptosis. A large number of studies have characterized p27 as an independent prognostic factor in various human cancers and as a target for cancer therapeutics. The function of p27 is regulated by changes in its intracellular concentration as well as in its sub-cellular localization in the cell. Many tumor cells show p27 down-regulated or no detectable expression, p27 might act as an adverse prognostic marker for various types of cancers. Until recently, displacement of p27 into the cytoplasm has been identified as a mechanism of which cancer cells promote cancerogenesis in human. But much less is known about the molecular mechanisms of its abnormal expression and mislocalization in tumor cell. p27 protein has various interacting molecules. The different formation of p27 complexes maybe cause disregulation of p27 expression and localization in human cancer. We hypothesize here that different interacting protein profile may be a fundamentional step for the abnormal expression and cytoplasmic localization in tumor cells.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Guan X,Chen L,Wang Jdoi
10.1016/j.mehy.2007.01.034subject
Has Abstractpub_date
2007-01-01 00:00:00pages
580-3issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00099-0journal_volume
69pub_type
杂志文章abstract::The morphological changes used to confirm a diagnosis of coeliac disease (CD) are precisely those predicted if the surface energy of the interface between duodenal epithelium and the luminal contents were raised to levels comparable to those demonstrated by the hydrophobic nature of the stomach wall. This hypothesis p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90126-y
更新日期:1990-07-01 00:00:00
abstract::Recent studies confirm that dietary methionine restriction increases both mean and maximal lifespan in rats and mice, achieving "aging retardant" effects very similar to those of caloric restriction, including a suppression of mitochondrial superoxide generation. Although voluntary caloric restriction is never likely ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.07.044
更新日期:2009-02-01 00:00:00
abstract::Neuronal degeneration in the post-menopausal term leads to cognitive symptoms such as anxiety, difficulty in concentrating, overreacting to minor upsets, quickly becoming irritated and forgetfulness in approximately 70-80% of all women around the world. These symptoms, which result from microtubule damage in the axon ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.06.013
更新日期:2013-09-01 00:00:00
abstract::So-called 'limited life span' of diploid cells does not depend on their unresponsiveness to growth factors from the data obtained by complete protein-free culture of tumor cells. Limited proliferation (called limited life span) of diploid cells is one of the 'ad-hoc' negative regulatory mechanisms in animals, and can ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90090-d
更新日期:1993-10-01 00:00:00
abstract::We propose that in any acid-base disturbance there is a predictable mathematical relationship between the changes in the individual serum anionic concentrations of chloride, bicarbonate and the unmeasured anion gap. Two indices were developed, from the ratios of the changes in these anionic concentrations, that are us...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90063-7
更新日期:1989-11-01 00:00:00
abstract::Immunology has many effects on atherogenesis. In addition to their usual action risk factors for atherosclerosis have an immunomodulating effect and immunomodulation may be a new treatment of atherosclerosis. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90159-v
更新日期:1991-09-01 00:00:00
abstract::Individuals with Down syndrome have signs of possible brain damage prior to birth. In addition to slowed and reduced mental development, they are much more likely to have cognitive deterioration and develop dementia at an earlier age than individuals without Down syndrome. Some of the cognitive impairments are likely ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.08.020
更新日期:2005-01-01 00:00:00
abstract::This paper will show that the fractional difference in the human gender ratio (GR) between the GR(at death) for those born in solar cycle peak years (maxima) and the GR(at death) in those born in solar cycle non-peak years (minima), e.g., 0.023, divided by Pi, yields a reasonable approximation of the quantum mechanica...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.028
更新日期:2009-09-01 00:00:00
abstract::In Burkitt's lymphoma, dental structures may provide the route for Epstein-Barr virus (EBV) in saliva to penetrate the jaws, thereby promoting tumor formation. In children, EBV could enter tooth sockets exposed following deciduous tooth loss and thereby contact jaw marrow lymphocytes stimulating neoplastic transformat...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(83)90105-6
更新日期:1983-12-01 00:00:00
abstract::Antidepressants, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and serotonin-noradrenalin reuptake inhibitors, are the main biological treatment for major depression. However, not all depressed patients improve clinically despite appropriate treatment. Thus,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.10.011
更新日期:2006-01-01 00:00:00
abstract::Previous reports of specific patterns of increased fragility at common chromosomal fragile sites (CFS) found in association with certain neurobehavioural disorders did not attract attention at the time due to a shift towards molecular approaches to delineate neuropsychiatric disorder candidate genes. Links with miRNA,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.05.039
更新日期:2010-05-01 00:00:00
abstract::Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical "malignancy". Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone des...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.011
更新日期:2008-01-01 00:00:00
abstract::It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2007.12.004
更新日期:2008-01-01 00:00:00
abstract::Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90034-a
更新日期:1992-08-01 00:00:00
abstract::The constant level of various proteins including albumin and cellular components in intravascular pool in vivo is strictly controlled by an unknown homeostatic mechanism, although there are fluctuations seen in pathologic conditions. Because the majority of the IgG in the serum is regarded as self-reactive natural aut...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.04.011
更新日期:2006-01-01 00:00:00
abstract::Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cel...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.05.037
更新日期:2017-07-01 00:00:00
abstract::One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90020-3
更新日期:1984-11-01 00:00:00
abstract::Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1997.0695
更新日期:1999-06-01 00:00:00
abstract::Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(91)90220-s
更新日期:1991-03-01 00:00:00
abstract::It is hypothesized that a topical application of a sulfonylurea drug, which can inhibit the ATP-sensitive potassium-gated channels (Kir6.X/SUR) present in human hair bulb tissues, will inhibit hair growth in a targeted manner. Diazoxide is used to treat severe hypoglycemia due to hyperinsulinism of infancy. However, t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.08.025
更新日期:2015-12-01 00:00:00
abstract::Review of 18th and 19th century psychiatric therapies raises the possibility that several may have altered the activity of vasopressin or Na-K-ATPase. Bleeding, whirling, nausea created by medicines, and vagus nerve stimulation by application of electricity through the skin all perturb the hypothalamic hormone, argini...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/j.mehy.2003.10.007
更新日期:2004-01-01 00:00:00
abstract::The nasal mucosa is very vascular, receiving more blood flow per cubic centimeter of tissue than does muscle, brain or liver (Drettner and Aust, 1974; [1]). This vascularity can present a major problem during sinus surgery. Surgeons routinely use topical vasoconstrictors in endoscopic sinus surgery however, the optima...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.03.009
更新日期:2014-06-01 00:00:00
abstract::Vasopressin is now commonly used to control bleeding during surgery of the cervix. In larger intravenous doses, vasopressin can cause coronary artery vasoconstriction and increase systemic vascular resistance. Nicotine has a similar effect on the coronary circulation. The effects of combining both these drugs has not ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90036-5
更新日期:1996-07-01 00:00:00
abstract::Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90247-n
更新日期:1993-09-01 00:00:00
abstract::The present analysis addresses the question of how it has been possible for academic medicine to grow and lose its creative productivity at the same time. A mathematical model is developed to simulate the mechanisms that govern growth of medical systems over time. Time-dependent growth of system size increases the occ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.02.028
更新日期:2005-01-01 00:00:00
abstract::NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...
journal_title:Medical hypotheses
pub_type: 信件
doi:10.1016/j.mehy.2020.109968
更新日期:2020-11-01 00:00:00
abstract::Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2007.10.016
更新日期:2008-01-01 00:00:00
abstract::Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes tak...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.10.027
更新日期:2016-12-01 00:00:00
abstract::We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extr...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.06.026
更新日期:2005-01-01 00:00:00
abstract::Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the curre...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.02.018
更新日期:2012-06-01 00:00:00