Abstract：
:A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy of positive and negative feedback stress hormone receptors by their natural ligands due to inhibition of specific enzymes which function to limit receptor occupancy. Specifically, it is suggested that PG inhibits 11-beta hydroxysteroid dehydrogenase one and ES inhibits catechol- O -methyl transferase, both of which reside in close proximity to stress hormone receptors and catalyse the degradation of stress hormones into inactive compounds. In addition, it is suggested that the increased energy said to result from PG and ES may be a consequence of their increasing the occupancy of stress hormone receptors which function to redistribute the body's energy reserves from regeneration to activity.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Gaffney BT,Hügel HM,Rich PAdoi
10.1054/mehy.2000.1163keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
567-72issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(00)91163-0journal_volume
56pub_type
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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