Abstract:
:Gas formed in tissues and the circulating blood due to decompression is thought to be a significant factor in the progression of decompression illness (DCI). DCI is a potential problem for a growing population of professional and recreational divers. We hypothesise that these gas bubbles are not the causative agent in progression of DCI, rather an exacerbating factor. Endothelial dysfunction caused by a temporary loss of haemostasis due to increased total oxidant status is postulated to be the cause in this at-depth endothelial dysfunction hypothesis. Breathing oxygen at any pressure increases the oxidant status in the circulation causing vasoconstriction; this increase can be prevented by antioxidants, such as Vitamin C, maintaining haemostasis and preventing activation of endothelium, leukocyte recruitment and subsequent localised inflammation. Bubbles have the potential to exacerbate the situation on decompression by damaging the vascular endothelium either through ischemia/reperfusion, physical contact with the endothelium or by an increase in shear stress. Furthermore, this damage may manifest itself in the release of endothelial membrane fragments (microparticles).
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Madden LA,Laden Gdoi
10.1016/j.mehy.2008.11.022subject
Has Abstractpub_date
2009-04-01 00:00:00pages
389-92issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(08)00601-4journal_volume
72pub_type
杂志文章abstract::Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore...
journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
abstract::The DSM is not brain-related and is thus unable to relate clinical assessments to putative brain disturbances. 'Clinical brain profiling' (CBP) involves the rearrangement of clinical findings to assess the relevant disturbances in brain dynamics. CBP has three major pathological dimensions, (1) disorders of basic brai...
journal_title:Medical hypotheses
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更新日期:2009-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.02.032
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109318
更新日期:2019-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.01.010
更新日期:2017-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.08.028
更新日期:2011-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.059
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90305-4
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.05.013
更新日期:2015-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.12.030
更新日期:2010-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0756
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1995-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00