A novel deployment design of vena cava filters might be the solution to their blockage problem.

Abstract:

:The blockage of a vena cava filter (VCF) by the captured blood clots presents a serious problem to the patients. Commercially available cone-shaped VCFs such as the Gunther Tulip filter has an inherent structural flaw that leads the captured blood clots to be trapped in their front spire areas where the flow-induced shear stress is relatively low so that the clots cannot dissolve fast enough and will accumulate, gradually block the central passages of the filters. It is well known that for a Hagen-Poiseuille flow in a circular tube, the flow-induced shear stress is highest at the wall of the tube and lowest along its axis. Herein, we hypothesize that by reversely deploying a cone-shaped filter in the vena cava, the filter's blockage problem might be prevented. First of all, this kind of deployment scenario can force the captured blood clots to stay in the peripheral areas of the vena cava and keep the central passage of the filter unblocked. Secondly, this scenario can expose the captured blood clots to relatively high shear stress that may dissolve the clots faster.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Chen Z,Fan Y,Deng X

doi

10.1016/j.mehy.2011.08.028

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

990-2

issue

6

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(11)00420-8

journal_volume

77

pub_type

杂志文章
  • Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury.

    abstract::Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. In neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full under...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2008.10.032

    authors: Kumral A,Tuzun F,Yesilirmak D,Duman N,Ozkan H

    更新日期:2009-06-01 00:00:00

  • Can we find a solution to the human immunodeficiency virus/acquired immune deficiency syndrome controversy? Is acquired immune deficiency syndrome the consequence of continuous excessive stressing of the body?

    abstract::The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(96)90192-9

    authors: Hässig A,Wen-Xi L,Stampfli K

    更新日期:1996-04-01 00:00:00

  • Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: role of the amygdala in developmental co-ordination.

    abstract::Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.08.029

    authors: Anderson G

    更新日期:2011-01-01 00:00:00

  • L-arginine: a therapeutic option for AIDS/HIV infection?

    abstract::Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(92)90101-h

    authors: Wrightham MN,Cann AJ,Sewell HF

    更新日期:1992-07-01 00:00:00

  • Mechanism of increased mortality in hemodialysed patients with periodontitis.

    abstract::Periodontitis significantly decreases survival in hemodialysed patients with end stage renal disease (ESRD). Periodontitis-related microorganisms spreading into the bloodstream are thought to impair blood rheological parameters - for example, increasing whole blood viscosity, aggregating blood elements, and decreasing...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.04.053

    authors: Sedý J,Horká E,Foltán R,Spacková J,Dusková J

    更新日期:2010-02-01 00:00:00

  • Active sleep and its role in the prevention of apoptosis in the developing brain.

    abstract::The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2004.01.014

    authors: Morrissey MJ,Duntley SP,Anch AM,Nonneman R

    更新日期:2004-01-01 00:00:00

  • Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome.

    abstract::Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is primarily caused by mutations in the Methyl CpG binding prote...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.09.015

    authors: Ben-Zeev B,Aharoni R,Nissenkorn A,Arnon R

    更新日期:2011-02-01 00:00:00

  • Auto T cells expressing chimeric antigen receptor derived from auto antibody might be a new treatment for osteosarcoma.

    abstract::Osteosarcoma is the most common primary malignant tumor of bone. Except for the improvement in five-year survival achieved by the adoption of neoadjuvant chemotherapy strategy, there are nearly no improvement for the treatment of osteosarcoma in the past 30 years, especially for the patients with metastatic disease. I...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.01.038

    authors: Weibo P,Zhaoming Y

    更新日期:2012-05-01 00:00:00

  • A pendular mechanism for maintenance of the immune memory.

    abstract::A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1132

    authors: Seledtsov VI,Seledtsova GV

    更新日期:2001-02-01 00:00:00

  • 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.

    abstract::The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109754

    authors: Ahmad SI

    更新日期:2020-09-01 00:00:00

  • Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

    abstract::Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...

    journal_title:Medical hypotheses

    pub_type: 信件

    doi:10.1016/j.mehy.2020.110202

    authors: Avcilar H,Eken A

    更新日期:2020-11-01 00:00:00

  • Detection of hepatitis B virus transcriptional activity: an hypothesis.

    abstract::This paper outlines a method of demonstrating hepatitis B virus (HBV)-related transcriptional activity based on the random amplification of cDNA ends (RACE) protocol. Following RNA extraction from the appropriate tissue, cDNA is synthesized using a long oligo d(T) based primer containing unique 5' oligonucleotide sequ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(95)90056-x

    authors: Sallie R

    更新日期:1995-08-01 00:00:00

  • New neural theory of migraine.

    abstract::Insufficient attention has been given to reports in the literature describing patients with symptomatic migraine who, in addition to, or instead of, the well-recognized zones of hypofusion, have zones of hyperperfusion, which can be interpreted as hypermetabolism due to neuronal activation. A new neural theory of migr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1214

    authors: Eggers AE

    更新日期:2001-03-01 00:00:00

  • Of schizophrenia, pruning, and epigenetics: a hypothesis and suggestion.

    abstract::One area of relative agreement in schizophrenic research is that there is grey matter volume deficit in various cortical areas associated with this illness. One theory attempting to explain this involves an exaggerated action of the normal CNS pruning process. Various aspects of this process were discussed along with ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.03.038

    authors: Rosenthal R

    更新日期:2011-07-01 00:00:00

  • The role of the nucleus in organogenesis: Part 1.

    abstract::Organogenesis is the result of cell allocation followed by cell differentiation, and the processes involved are still to be elucidated. Present-day teaching suggests that the cytoplasmic membrane, the extracellular matrix and the cytoskeleton, in combination, are responsible, but the literature also suggests that othe...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(96)90249-2

    authors: Drummond R

    更新日期:1996-03-01 00:00:00

  • Can snus (Swedish moist snuff) be used as a treatment of Pyoderma gangrenosum?

    abstract::Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2012.01.039

    authors: Kluger N

    更新日期:2012-05-01 00:00:00

  • Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy.

    abstract::Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment....

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.01.084

    authors: Zhang DW,Yang QS,Zhu JY,Cao XR,Li LW,Zhu QS

    更新日期:2007-01-01 00:00:00

  • CRPS: A contingent hypothesis with prostaglandins as crucial conversion factor.

    abstract:UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2015.07.017

    authors: van der Veen P

    更新日期:2015-11-01 00:00:00

  • Role of the prostate in the regulation of pituitary secretion of follicle stimulating hormone.

    abstract::The secretion of Follicle Stimulating Hormone by the pituitary gland is not regulated entirely by the negative feedback from gonadal steroids. There is ample evidence that the secretion of FSH is regulated by a non-steroidal hormone of gonadal origin termed "inhibin". Using a radioimmunoassay procedure, immunoreactive...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(84)90119-1

    authors: Sheth AR,Vanage GR,Hurkadli KS,Sheth NA

    更新日期:1984-10-01 00:00:00

  • Can chronic increased intracranial pressure or exposure to repetitive intermittent intracranial pressure elevations raise your risk for Alzheimer's disease?

    abstract::Over a decade ago, I formulated the hypothesis that cumulative effects of exposure to high intracranial pressure (ICP) may contribute to the development of Alzheimer's disease (AD), though not necessarily in an exclusive way. In addition to individual ICP characteristics (high 'physiological' ICP) and diseases causing...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2004.01.013

    authors: Wostyn P

    更新日期:2004-01-01 00:00:00

  • Sulfite oxidase deficiency: a high risk factor in SO2, sulfite, and bisulfite toxicity?

    abstract::It has been hypothesized that sulfite oxidase deficient persons may be at increased risk to toxicity from SO2 and dietary sulfites widely used for food preservation. Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Human and animal studies have shown ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90110-9

    authors: Calabrese E,Sacco C,Moore G,DiNardi S

    更新日期:1981-02-01 00:00:00

  • Could cells from menstrual blood be a new source for cell-based therapies?

    abstract::Human endometrium is a highly regenerative tissue and contains a low number of cells which have high replicative ability and differentiation efficiency. This has been identified by many scientists. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capab...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2008.10.021

    authors: Zhang MJ,Liu B,Xia W,Sun ZY,Lu KH

    更新日期:2009-03-01 00:00:00

  • Balanced intakes of natural triglycerides for optimum nutrition: an evolutionary and phytochemical perspective.

    abstract::Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(97)90210-3

    authors: Broadhurst CL

    更新日期:1997-09-01 00:00:00

  • Lipoproteins versus structural glycoproteins: atherosclerosis as an analogue and competitor of normal connective tissue interactions.

    abstract::There is a striking resemblance, in amino-acid composition and properties, between one class of structural glycoproteins from connective tissue and the apo low density lipoproteins (LDL) of blood plasma. It is suggested that there is a structurally specific analogy between the early atherogenic accumulation of LDL (an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(76)90039-6

    authors: Bowness JM

    更新日期:1976-09-01 00:00:00

  • A new therapy for refractory partial epilepsy: current shunt.

    abstract::A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.07.046

    authors: Zhang L,Liang S,Zhang G,Kang X

    更新日期:2013-11-01 00:00:00

  • Atherosclerosis as an immune disease?

    abstract::Immunology has many effects on atherogenesis. In addition to their usual action risk factors for atherosclerosis have an immunomodulating effect and immunomodulation may be a new treatment of atherosclerosis. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(91)90159-v

    authors: Clerc G

    更新日期:1991-09-01 00:00:00

  • Musculoskeletal overuse injuries and heart rate variability: Is there a link?

    abstract::Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2015.12.003

    authors: Gisselman AS,Baxter GD,Wright A,Hegedus E,Tumilty S

    更新日期:2016-02-01 00:00:00

  • A new therapeutic approach for the treatment of sepsis.

    abstract::Despite important advances in understanding its pathophysiology, therapy for septic shock remains largely symptomatic and supportive. Aiming to elevate the systemic arterial blood pressure by using vasoconstrictor manoeuvers are preferred without paying much attention to the ischaemia produced at the peripheral tissue...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2003.11.009

    authors: Iskit AB,Guc MO

    更新日期:2004-01-01 00:00:00

  • Water pipe smoking and human oral cancers.

    abstract::While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, th...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.10.013

    authors: Rastam S,Li FM,Fouad FM,Al Kamal HM,Akil N,Al Moustafa AE

    更新日期:2010-03-01 00:00:00

  • Aluminum-containing antacids as a cause of idiopathic Parkinson's disease.

    abstract::The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1997.0701

    authors: Altschuler E

    更新日期:1999-07-01 00:00:00