Abstract:
:This study investigated whether or not the anesthetic effect of ketamine in rats is dependent on adrenal gland hormones. The study was performed on two main rat groups, intact and adrenalectomized. Rat were divided into subgroups and given appropriate doses of ketamine, metyrapone or metyrosine. Durations of anesthesia in the groups were then recorded. Endogenous catecholamine levels were measured in samples taken from peripheral blood. This experimental results showed that ketamine did not induce anesthesia in intact rats at doses of 15 or 30mg/kg, and that at 60mg/kg anesthesia was established for only 11min. However, ketamine induced significant anesthesia even at a dose of 30mg/kg in animals in which production of endogenous catecholamine (adrenalin, noradrenalin dopamine) was inhibited with metyrosine at a level of 45-47%. Ketamine at 60mg/kg in animals in which endogenous catecholamine was inhibited at a level of 45-47% established anesthesia for 47.6min. However, ketamine at 30 and 60mg/kg induced longer anesthesia in adrenalectomized rats with higher noradrenalin and dopamine levels but suppressed adrenalin production. Adrenalin plays an important role in the control of duration of ketamine anesthesia, while noradrenalin, dopamine and corticosterone have no such function. If endogenous adrenalin is suppressed, ketamine can even provide sufficient anesthesia at a 2-fold lower dose. This makes it possible for ketamine to be used in lengthy surgical procedures.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Aksoy M,Ince I,Ahiskalioglu A,Dostbil A,Celik M,Turan MI,Cetin N,Suleyman B,Alp HH,Suleyman Hdoi
10.1016/j.mehy.2014.03.033subject
Has Abstractpub_date
2014-07-01 00:00:00pages
103-7issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(14)00146-7journal_volume
83pub_type
杂志文章abstract::The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endotheli...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.11.049
更新日期:2009-12-01 00:00:00
abstract::Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (C...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109790
更新日期:2020-04-24 00:00:00
abstract::The dissimilarities in spin-lattice relaxation time (T1) of water proton from one tumor to the other is due to the yield of hypoxic fraction in the tumor. The yield of higher relaxation time (T1) in the KHT tumor compared to the RIF-1 tumor as a function of growth is due to the hypoxic fraction of the tumor. The hypox...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90007-y
更新日期:1992-01-01 00:00:00
abstract::An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00253-0
更新日期:2002-08-01 00:00:00
abstract::The article introduces the hypothesis that aquaporin 1 of intramuscular capillary endothelial cells may enhance the capability of the skeletal myofiber regeneration. Evidence for the hypothesis is based on the indication obtained from our previous muscle xenograft study into athymic nude mice, and the indications prop...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.07.056
更新日期:2007-01-01 00:00:00
abstract::Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90226-1
更新日期:1996-01-01 00:00:00
abstract::In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00325-6
更新日期:2004-01-01 00:00:00
abstract::The present analysis addresses the question of how it has been possible for academic medicine to grow and lose its creative productivity at the same time. A mathematical model is developed to simulate the mechanisms that govern growth of medical systems over time. Time-dependent growth of system size increases the occ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.02.028
更新日期:2005-01-01 00:00:00
abstract::The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90266-x
更新日期:1995-05-01 00:00:00
abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.12.040
更新日期:2013-04-01 00:00:00
abstract::Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110070
更新日期:2020-10-01 00:00:00
abstract::Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.08.026
更新日期:2018-12-01 00:00:00
abstract::The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90063-5
更新日期:1985-04-01 00:00:00
abstract::For American medical historiography, to borrow from Dickens, these are the best of times and the worst of times. These are the times when rigorous scholarship has been brought to bear on the field (with great improvement in the quality of research) and when medicine is disappearing from its own history. These are the ...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/0306-9877(92)90079-r
更新日期:1992-06-01 00:00:00
abstract::Bovine serum albumin and human serum transferrin modified by the water soluble carbodiimides N-ethyl-N'-(3-dimethyl propylamino) carbodiimide (CDI) or N-ethyl-N'-(3-trimethyl propylammonium) carbodiimide (Me+CDI) to yield N-acylurea proteins bind pBR322 DNA reversibly showing electrostatic and non-electrostatic compon...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90044-2
更新日期:1987-09-01 00:00:00
abstract::The theory presented herewith provides a unified explanation for neoplasia and teratogenesis, both regarded here as stem cell disorders. Proliferating cells in the organism form two mutually exclusive classes, immortal stem cells and transitional cells whose life span is limited. Any lasting change in the organism e.g...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90013-1
更新日期:1985-03-01 00:00:00
abstract::Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in pas...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2018.03.019
更新日期:2018-06-01 00:00:00
abstract::It has been shown previously that the precipitator hypothesis of causation is able to account for certain key features of the epidemiological evidence that conflict with initiator and promoter hypotheses. The precipitator hypothesis states that the carcinogenic risk depends linearly in the average rate of smoking at a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90145-6
更新日期:1981-12-01 00:00:00
abstract::The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(98)90277-8
更新日期:1998-06-01 00:00:00
abstract::Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.07.028
更新日期:2008-12-01 00:00:00
abstract::Oral water irrigation devices (WIDs) are widely used for oral physiotherapy in homes and dental clinics throughout the world. A major area of concern in the use of WIDs has been the possibility of injury to the sulcular epithelium and underlying tissue. There are several documented clinical cases of tissue injury with...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90110-0
更新日期:1985-12-01 00:00:00
abstract::Previous research from our group suggests that patients with lesions in the left inferior parietal lobule (IPL)-which is concerned with abstract numerical cognition and cross-modal association (which is consistent with its strategic location at the crossroads between the temporal, parietal and occipital lobes) have di...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.01.033
更新日期:2014-06-01 00:00:00
abstract::A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.1026
更新日期:2000-07-01 00:00:00
abstract::Articles dealing with the epidemiological aspects of asthma were carefully reviewed in order to support or reject our clinical impression of increased rate of asthma among immigrants. Particular emphasis was put on data on very high or very low rates of asthma. The proposed theories to explain these differences were c...
journal_title:Medical hypotheses
pub_type: 杂志文章,meta分析
doi:10.1016/s0306-9877(98)90047-0
更新日期:1998-10-01 00:00:00
abstract:UNLABELLED:Teeth start as bi-layered epithelial soft tissue follicles within bony jaws. Follicles grow into teeth and erupt. Early third molar follicles are detectable 8-9 years (±9 months). Intra-oral dental arches of jaws have finite space accommodating formed crowns. The last teeth to erupt are third molars. When th...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.05.031
更新日期:2012-09-01 00:00:00
abstract::Goldberger discovered human pellagra was a non-infectious disease, affecting mostly the small and the timid in overcrowded institutions. Symptoms were diarrhoea, dermatitis and dementia. The staff and older children escaped the disease. They ate the meat and left the small and timid with the gravy. The 'Goldberger syn...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90009-f
更新日期:1993-05-01 00:00:00
abstract::This paper will show that the fractional difference in the human gender ratio (GR) between the GR(at death) for those born in solar cycle peak years (maxima) and the GR(at death) in those born in solar cycle non-peak years (minima), e.g., 0.023, divided by Pi, yields a reasonable approximation of the quantum mechanica...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.028
更新日期:2009-09-01 00:00:00
abstract::Evidence is reviewed supporting a hypothesis of an anticarcinogenic effect of magnesium. Animal studies reported increased cancer in rodents maintained on magnesium deficient diets and a preventive effect for rodents fed excess levels of magnesium. Epidemiologic evidence is presented that magnesium levels in water, fo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(80)90010-9
更新日期:1980-08-01 00:00:00
abstract::Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theorie...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.01.008
更新日期:2017-03-01 00:00:00
abstract::The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.03.004
更新日期:2015-06-01 00:00:00