Prediction of neuropathy, neuropathic pain and kinesiophobia in patients with type 2 diabetes and design of computerized clinical decision support systems by using artificial intelligence.

abstract：:Hyperemesis gravidarum (HG) is the most severe form of illness within the spectrum of nausea and vomiting of pregnancy. Liver disease, usually consisting of mild serum transaminase elevation, occurs in almost 50% of patients with HG. While multiple risk factors have been proposed, the etiology and underlying mechanism...

journal_title：Medical hypotheses

authors： Outlaw WM,Ibdah JA

更新日期：2005-01-01 00:00:00

abstract：:The aetiology of multiple sclerosis suggests that its occurrence depends on a combination of factors, including viral infection in early childhood, genotype and an initiating event within the central nervous system. The resulting damage may be caused by events initiated by free radicals. Free radicals themselves may c...

journal_title：Medical hypotheses

authors： Cooper RL

更新日期：1997-10-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...

journal_title：Medical hypotheses

authors： Sabayan B,Zolghadrasli A

更新日期：2007-01-01 00:00:00

abstract：:No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

journal_title：Medical hypotheses

authors： Warner TF,Azen EA

更新日期：1988-06-01 00:00:00

abstract：:Restless legs syndrome (RLS) exhibits sensorimotor symptoms. In familial cases, a gene at chromosomal location 9p-24-22 is linked to RLS and the expressed mutation is Dopamine Receptor Specific Individual Sensitivity (DRSIS). The symptoms are triggered during changes in alertness, generally at sleep hours, resulting f...

journal_title：Medical hypotheses

authors： Akpinar S

更新日期：2009-08-01 00:00:00

abstract：:Meditation is used worldwide by millions of people for relaxation and stress relief. Given sufficient practice, meditators may also experience a variety of altered states of consciousness. These states can lead to a variety of unusual experiences, including physical, emotional and psychic disturbances. This paper high...

journal_title：Medical hypotheses

authors： Lindsay S

更新日期：2014-10-01 00:00:00

abstract：:It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of differen...

journal_title：Medical hypotheses

authors： Fang CH,Li JJ,Hui RT

更新日期：2005-01-01 00:00:00

abstract：:In idiopathic scoliosis the convexity of the thoracic curve of the vertebral column is most commonly directed toward the right side. The right lung is normally larger than the left lung. This asymmetry acting through chest wall movement is hypothesized to exert rotatory forces on the vertebral column. The result, in p...

journal_title：Medical hypotheses

authors： Del Bigio MR

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

journal_title：Medical hypotheses

authors： Tavakol S

更新日期：2014-12-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...

journal_title：Medical hypotheses

authors： El-Badri NS,Groer M

更新日期：2012-10-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...

journal_title：Medical hypotheses

authors： Verlangieri AJ,Kapeghian JC,el-Dean S,Bush M

更新日期：1985-01-01 00:00:00

abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

journal_title：Medical hypotheses

authors： Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

更新日期：2011-07-01 00:00:00

abstract：:As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...

journal_title：Medical hypotheses

authors： Gerashchenko BI,Murata-Hori M,Hosoya H

更新日期：2000-05-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a severe, occlusive, thrombotic microangiopathy characterized by a systemic platelet aggregation, organ ischemia, profound thrombocytopenia and erythrocyte fragmentation. Recent observations have documented that a deficiency of a von Willebrand factor (VWF)-cleaving proteas...

journal_title：Medical hypotheses

authors： Franchini M

更新日期：2005-01-01 00:00:00

abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

journal_title：Medical hypotheses

authors： Cai DW

更新日期：1995-05-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00

abstract：:Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...

journal_title：Medical hypotheses

authors： Carlyle IP

更新日期：1997-12-01 00:00:00

abstract：:Acute carbon monoxide (CO) poisoning causes the neurologic symptoms and brain lesions during both acute and delayed phase. We propose that catecholamine crises in globus pallidus and deep white matter are the key pathophysiological factors causing acute and delayed brain injuries respectively. Increased sympathetic ac...

journal_title：Medical hypotheses

authors： Park EJ,Min YG,Kim GW,Cho JP,Maeng WJ,Choi SC

更新日期：2014-08-01 00:00:00

abstract：:Recent studies suggest that blood-borne metabolites of gut microbiota, such as trimethylamine N-oxide (TMAO) are involved in the aetiology of cardiovascular diseases and may serve as markers of cardiovascular risk. To enter the bloodstream the microbiota-derived molecules need to pass the gut-blood barrier (GBB). The ...

journal_title：Medical hypotheses

authors： Ufnal M,Pham K

更新日期：2017-01-01 00:00:00

abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

journal_title：Medical hypotheses

authors： Kawano T

更新日期：2003-05-01 00:00:00

abstract：:The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...

journal_title：Medical hypotheses

authors： Morrissey MJ,Duntley SP,Anch AM,Nonneman R

更新日期：2004-01-01 00:00:00

abstract：:Obstructive sleep apnea is characterized by episodes of intermittent hypoxia that occur while the afflicted person sleeps, and is believed to affect and have a negative impact on many people worldwide. Both observational evidence in obstructive sleep apnea patients and direct studies in mice mimicking the disease stro...

journal_title：Medical hypotheses

authors： Johnson PR

更新日期：2008-10-01 00:00:00

abstract：:The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...

journal_title：Medical hypotheses

authors： Falkenbach A,Klauke S,Althoff PH

更新日期：1990-09-01 00:00:00

abstract：:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstra...

journal_title：Medical hypotheses

authors： Chiang PK,Yang FY

更新日期：2019-01-01 00:00:00

abstract：:A recent published model described the phenomenon of a global panic reaction (GPR) on the stock markets based on two remarkable stock market crashes in the months of January and March [Sperling W, Bleich S, Reulbach U, Black Monday on stock markets throughout the world - a new phenomenon of collective panic disorder? ...

journal_title：Medical hypotheses

authors： Sperling W,Biermann T

更新日期：2009-11-01 00:00:00

abstract：:Lactic acid produced by the malignant tumor is what keeps the malignancy going. Suppression or the removal of lactic acid is the prerequisite for any cancer treatment. ...

journal_title：Medical hypotheses

authors： Niakan B

更新日期：2001-05-01 00:00:00

abstract：:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

journal_title：Medical hypotheses

authors： Walker LC,Herndon JG

更新日期：2010-06-01 00:00:00