A potential treatment of low intensity pulsed ultrasound on cavernous nerve injury for erectile dysfunction.

Abstract:

:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstrated that low-intensity pulsed ultrasound (LIPUS) accelerates bone healing and axonal regeneration after injury. LIPUS may also be able to stimulate neuronal activity and enhance the levels of neurotrophic factors. Evidence suggests that elevated levels of BDNF in the brain have protective effects against neurodegenerative diseases. Previous studies have shown that the treatment on cavernous nerve injury repair, and protective effect plus neuro-regeneration effect by low-intensity pulsed ultrasound. They shared the similar mechanism including several trophic factors stimulation, Pl3K/akt pathway activation, and anti-fibrosis mechanism. We hypothesized that due to its combined neuroregenerative and protective effects, the non-invasive and easy-to-use method of LIPUS stimulation could have a therapeutic effect on erectile dysfunction stemming from cavernous nerve injury.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Chiang PK,Yang FY

doi

10.1016/j.mehy.2018.10.014

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

19-21

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(18)30861-2

journal_volume

122

pub_type

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