Abstract:
:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstrated that low-intensity pulsed ultrasound (LIPUS) accelerates bone healing and axonal regeneration after injury. LIPUS may also be able to stimulate neuronal activity and enhance the levels of neurotrophic factors. Evidence suggests that elevated levels of BDNF in the brain have protective effects against neurodegenerative diseases. Previous studies have shown that the treatment on cavernous nerve injury repair, and protective effect plus neuro-regeneration effect by low-intensity pulsed ultrasound. They shared the similar mechanism including several trophic factors stimulation, Pl3K/akt pathway activation, and anti-fibrosis mechanism. We hypothesized that due to its combined neuroregenerative and protective effects, the non-invasive and easy-to-use method of LIPUS stimulation could have a therapeutic effect on erectile dysfunction stemming from cavernous nerve injury.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Chiang PK,Yang FYdoi
10.1016/j.mehy.2018.10.014subject
Has Abstractpub_date
2019-01-01 00:00:00pages
19-21eissn
0306-9877issn
1532-2777pii
S0306-9877(18)30861-2journal_volume
122pub_type
杂志文章abstract::Parkinson disease (PD) is a chronic progressive degenerative disorder that affects over 6 million people worldwide. It is manifested by motor and psychiatric signs. The latter inflicts up to 88% of PD patients. With the prolongation of life expectancy, it is presumed that the prevalence of PD will further rise, togeth...
journal_title:Medical hypotheses
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pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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更新日期:2019-03-01 00:00:00
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2012.01.001
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Medical hypotheses
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