Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome.

abstract：:Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

journal_title：Medical hypotheses

authors： Mladina R,Skitarelić N

更新日期：2010-10-01 00:00:00

abstract：:The results described in this paper partially agree with the hypothesis that mesenteric lymph nodes (MLN) of depleted growing rats recover their antigen specific determinants after the oral administration of 20% casein for 5-9 days following the time course of antigen dependent changes observed in virgin lymph nodes. ...

journal_title：Medical hypotheses

authors： Langini SH,López MC,Slobodianik NH,Sanahuja JC,Rio ME,Roux ME

更新日期：1987-08-01 00:00:00

abstract：:The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...

journal_title：Medical hypotheses

authors： Oliveira DBG

更新日期：2018-03-01 00:00:00

abstract：:Although the classical ideal is that scientific theories are evaluated by a careful teasing-out of their internal logic and external implications, and checking whether these deductions and predictions are in-line-with old and new observations; the fact that so many vague, dumb or incoherent scientific theories are app...

journal_title：Medical hypotheses

authors： Charlton BG

更新日期：2008-09-01 00:00:00

abstract：:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

journal_title：Medical hypotheses

authors： Zhang L,Liang S,Zhang G,Kang X

更新日期：2013-11-01 00:00:00

abstract：:Atherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that t...

journal_title：Medical hypotheses

authors： Nesnawy S,Tolba K,Roshdy I,Abdel Kader M

更新日期：2020-02-01 00:00:00

abstract：:We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0...

journal_title：Medical hypotheses

authors： Szczuko M,Splinter J,Zapałowska-Chwyć M,Ziętek M,Maciejewska D

更新日期：2019-07-01 00:00:00

abstract：:Persistently infecting DNA viruses depend heavily on host cell DNA synthesis machinery. Replication of cellular and viral DNA is inhibited by mutagenic stress. It is hypothesized that diurnal regulation of viral DNA replication may occur at the level of cell cycle checkpoints and DNA repair, to protect DNA from exposu...

journal_title：Medical hypotheses

authors： Shadan FF

更新日期：2007-01-01 00:00:00

abstract：:Growing evidence has indicated the existence of deleterious networks in the brains of neurodegenerative disorders, including Alzheimer's disease. Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. The deleterious networks are formed on the basis of the intimate interactions among the key path...

journal_title：Medical hypotheses

authors： Ying W

更新日期：1996-10-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

journal_title：Medical hypotheses

authors： Kawano T

更新日期：2003-05-01 00:00:00

abstract：:Structures which morphologically resemble treponemes have been found in material from patients suffering from latent or late latent syphilis, many of whom have received treatment in the past. These structures were also found in the blood or spinal fluid (SF) of asymptomatic patients with both positive and negative ser...

journal_title：Medical hypotheses

authors： Ghinsberg RC,Nitzan Y

更新日期：1992-09-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on t...

journal_title：Medical hypotheses

authors： Ventolini G,Gygax SE,Adelson ME,Cool DR

更新日期：2013-08-01 00:00:00

abstract：:This article proposes the hypothesis that allantois is the anatomical homologue of bursa of Fabricius in mammalia. This hypothesis is based on immunohistochemical study of sections from hematopoietic organs of three fetuses with cloacal exstrophy. In the complex maldevelopment of cloacal exstrophy the common features ...

journal_title：Medical hypotheses

authors： Zarabi CM

更新日期：1990-06-01 00:00:00

abstract：:The levator ani muscles in women are overloaded by constant supporting abdominal contents, and counteracting rises of abdominal pressure at the level of the urethra. The excessive load leads to a decrease in their type II fibers. This results in stress urinary incontinence due to loss of the fibers responsible for add...

journal_title：Medical hypotheses

authors： Jóźwik M

更新日期：1993-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a major cause of morbidity and mortality among older individuals. Although the causes of Parkinson's disease are multifactorial, considerable evidence indicates that elevated labile iron in the substantia nigra pars compacta plays an important role in producing oxyradicals which subsequentl...

journal_title：Medical hypotheses

authors： Edwin Shackelford R,Manuszak RP,Heard SC,Link CJ,Wang S

更新日期：2005-01-01 00:00:00

abstract：:It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...

journal_title：Medical hypotheses

authors： Charlton BG,Andras P

更新日期：2008-01-01 00:00:00

abstract：:Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...

journal_title：Medical hypotheses

authors： Schrier E,Dijkstra PU,Zeebregts CJ,Wolff AP,Geertzen JHB

更新日期：2018-12-01 00:00:00

abstract：:This paper compares two models of the sense of smell and demonstrates that the new model has advantages over the accepted model with implications for medical research. The accepted transduction model had an odourant or pheromone contacting an aqueous sensory lymph then movement through it to a receptor membrane beneat...

journal_title：Medical hypotheses

authors： Nicholson B

更新日期：2001-09-01 00:00:00

abstract：:Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island of Guam,a very high incidence of sALS occ...

journal_title：Medical hypotheses

authors： Stommel EW,Field NC,Caller TA

更新日期：2013-02-01 00:00:00

abstract：:Secretion of ovarian hormones directly into the peritoneal cavity has been repeatedly demonstrated for 25 years, but the consequences of this pathway of secretion have not been fully considered. Circumstantial evidence suggests the following hypotheses: (1) Hormones enter the endometrial cavity through the tubes and i...

journal_title：Medical hypotheses

authors： Foster EA

更新日期：2003-06-01 00:00:00

abstract：:This hypothesis named Salerian Addictive Potential (SAP) suggests that the addictive potency of any substance may be calculated with an algebraic equation of A=E/T(max)xt(1/2), where A is the addictive potency, E represents the euphoric potency, T(max) is the time to reach peak plasma concentration, and t(1/2) is the ...

journal_title：Medical hypotheses

authors： Salerian AJ

更新日期：2010-06-01 00:00:00

abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...

journal_title：Medical hypotheses

authors： Levy M,Ehrenfeld M,Gallily R,Eliakim M

更新日期：1981-01-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:Cardiovascular calcification (CVC) associated with conditions such as ageing, diabetes or renal impairment, results from the deposition of hydroxyapatite in the endothelium or media of blood vessels. Key medical management options are directed towards controlling plasma calcium and phosphate concentrations (e.g. parat...

journal_title：Medical hypotheses

authors： Joubert P,Ketteler M,Salcedo C,Perello J

更新日期：2016-09-01 00:00:00

abstract：:Complex Regional Pain Syndrome (CRPS) has defied a clear unified pathological explanation to date. Not surprisingly, treatments for the condition are limited in number, efficacy and their ability to enact a cure. Whilst many observations have been made of physiological abnormalities, how these explain the condition an...

journal_title：Medical hypotheses

authors： Russo M,Georgius P,Santarelli DM

更新日期：2018-10-01 00:00:00

abstract：:It is suggested that apart from aflatoxins, plant medicinal preparations containing active compounds imperatorin, dictamine, marmesin and heraclenin may be responsible for some human cancers in Nigeria and perhaps other parts of Africa. Therefore, in this paper, a hypothesis is put forward that these compounds or thei...

journal_title：Medical hypotheses

authors： Adekunle AA,Adekunle LV

更新日期：1983-07-01 00:00:00

abstract：:The etiology of intra-abdominal adhesions is explained by hydrolysis of the peritoneal phospholipid layer caused by phospholipase A2 activity. This view could unify the pre-existing hypotheses that intra-abdominal adhesions are due to ischemia or increased plasminogen activator activity. New therapeutic approaches are...

journal_title：Medical hypotheses

authors： Snoj M

更新日期：1993-12-01 00:00:00

abstract：:Sickle cell anaemia confirms that minor mutations in protein sequence can have catastrophic effects. However, RNA transcription depends on polymerases that have low fidelity and introduce errors at a rate of 10(-5) substitutions/base synthesised. For many large proteins translation of these errors could result in sign...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00