Enhanced polymorphonuclear chemotaxis - a common feature of diseases responsive to colchicine.

abstract：:Immunology has many effects on atherogenesis. In addition to their usual action risk factors for atherosclerosis have an immunomodulating effect and immunomodulation may be a new treatment of atherosclerosis. ...

journal_title：Medical hypotheses

authors： Clerc G

更新日期：1991-09-01 00:00:00

abstract：:Endophthalmitis following pars-plana procedures such as a vitrectomy vitreo-retinal procedures has been infrequently reported in literature. The cited incidence is about 0.1% to 0.2%. In the 8 cases of endophthalmitis that have been reported in literature, the prognosis has been indicated as very poor due to a delay i...

journal_title：Medical hypotheses

authors： Venkatesh P,Verma L,Tewari H

更新日期：2002-06-01 00:00:00

abstract：:Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

journal_title：Medical hypotheses

authors： Javanbakht A

更新日期：2006-01-01 00:00:00

abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...

journal_title：Medical hypotheses

authors： Wrightham MN,Cann AJ,Sewell HF

更新日期：1992-07-01 00:00:00

abstract：:It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant). Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment,...

journal_title：Medical hypotheses

authors： Garrison RL,Breeding PC

更新日期：2003-08-01 00:00:00

abstract：:Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...

journal_title：Medical hypotheses

authors： Wachtel LE,Dhossche DM

更新日期：2010-07-01 00:00:00

abstract：:Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All select...

journal_title：Medical hypotheses

authors： Ghika J

更新日期：2008-11-01 00:00:00

abstract：:There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proi...

journal_title：Medical hypotheses

authors： Myint AM,Kim YK

更新日期：2003-11-01 00:00:00

abstract：:To explain why subjects vary in body fat content despite similar nutrient intake and physical activity, a hypothesis is proposed invoking individual variability in the potentially vast quantities of energy utilizable for such biomechanical functions as cellular motility processes, and for protein mobility. The collect...

journal_title：Medical hypotheses

authors： Roncari DA

更新日期：1987-05-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:Traumatic iris sphincter tear has been thought to occur secondary to anteroposterior compression of the globe with defined forces lead to equatorial expansion and active pull along the corneoscleral junction and sphincter tear. However, here in this report, we elaborate the additional forces involved in the traumatic ...

journal_title：Medical hypotheses

authors： Pujari A,Agarwal D,Kumar Behera A,Bhaskaran K,Sharma N

更新日期：2019-01-01 00:00:00

abstract：:High level contamination by natural and industrial sources of the alkali earth metal, barium (Ba) has been identified in the ecosystems/workplaces that are associated with high incidence clustering of multiple sclerosis (MS) and other neurodegenerative diseases such as the transmissible spongiform encephalopathies (TS...

journal_title：Medical hypotheses

authors： Purdey M

更新日期：2004-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight ...

journal_title：Medical hypotheses

authors： Hayes CE,Donald Acheson E

更新日期：2008-01-01 00:00:00

abstract：:In normal and hypertensive subjects, many stimuli which increase ACTH secretion also increase blood pressure and conversely, many drugs which decrease ACTH secretion also decrease blood pressure. We postulate that the hypothalamopituitary adrenal axis plays a role in blood pressure regulation in normal and hypertensiv...

journal_title：Medical hypotheses

authors： Whitworth JA,McLachlan-Troup N,Scoggins BA

更新日期：1987-07-01 00:00:00

abstract：:Purpura fulminans is a life threatening complication of many septic states, most notably meningococcaemia. It can also occur due to congenital deficiency of anticoagulant proteins. The pathophysiology of purpura fulminans is complex and not fully understood, but involves abnormalities of coagulation pathways, damage t...

journal_title：Medical hypotheses

authors： Oram J,Bodenham A

更新日期：2008-01-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...

journal_title：Medical hypotheses

authors： Brown DW

更新日期：1994-06-01 00:00:00

abstract：:Cancer is the second cause of death worldwide, but current therapies are often insufficient or linked with toxicity. Initial evidence in scientific literature seems to support the role of non-pharmacological strategies, including hypoglycemia, in cancer treatment. The biological rationale for hypoglycemia-based treatm...

journal_title：Medical hypotheses

authors： Baiardo Redaelli M,Zangrillo A,Gregorc V,Ciceri F,Dagna L,Tshomba Y,Navalesi P,Landoni G

更新日期：2019-09-01 00:00:00

abstract：:Alzheimer's disease (AD) includes etiologically heterogeneous disorders characterized by senile or presenile dementia, extracellular amyloid protein aggregations containing an insoluble amyloid precursor protein derivative, and intracytoplasmic tau protein aggregations. Recent studies also show excess neuronal aneuplo...

journal_title：Medical hypotheses

authors： Swerdlow RH,Khan SM

更新日期：2004-01-01 00:00:00

abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...

journal_title：Medical hypotheses

authors： Julu POO,Shah M,Monro JA,Puri BK

更新日期：2018-01-01 00:00:00

abstract：:From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...

journal_title：Medical hypotheses

authors： Sri Kantha S

更新日期：2001-12-01 00:00:00

abstract：:A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...

journal_title：Medical hypotheses

authors： Brietzke E,Mansur RB,Grassi-Oliveira R,Soczynska JK,McIntyre RS

更新日期：2012-05-01 00:00:00

abstract：:Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin sepa...

journal_title：Medical hypotheses

authors： Megson MN

更新日期：2000-06-01 00:00:00

abstract：:The hypterphosphorylation of tau proteins is a well-established step in the expression of the pathological features in Alzheimer's disease (AD). While a primary event that links aluminum and AD, the so-called 'aluminum hypotheses', is far from being demonstrated, however, the metal ion could be an important etiologica...

journal_title：Medical hypotheses

authors： Zatta PF

更新日期：1995-03-01 00:00:00

abstract：:To compensate for the high metabolic costs of lactation, the likelihood of re-impregnation shortly after childbirth is normally reduced due to hormonal changes triggered by breast feeding during the postpartum period. Nowadays, however, bottle feeding as a substitute for breast feeding precludes such changes and leads...

journal_title：Medical hypotheses

authors： Gallup GG Jr,Hobbs DR

更新日期：2011-09-01 00:00:00

abstract：:Although fibrosis and emphysema are in many ways on opposite ends of the pulmonary parenchymal disease spectrum, they seem to share common pathomechanistic steps. This is illustrated by the coexistence of both entities in lungs of individuals with combined pulmonary fibrosis and emphysema. Macroproteins elastin and co...

journal_title：Medical hypotheses

authors： Janssen R,de Brouwer B,von der Thüsen JH,Wouters EFM

更新日期：2018-11-01 00:00:00

abstract：:Schizophrenia has a polygenic mode of inheritance and an estimated heritability of over 80%, but success in understanding its genetic underpinnings to date has been modest. Unlike in trinucleotide neurodegenerative disorders, the phenomenon of genetic anticipation observed in schizophrenia or bipolar disorder has not ...

journal_title：Medical hypotheses

authors： Hegde MV,Saraph AA

更新日期：2011-08-01 00:00:00

abstract：:Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...

journal_title：Medical hypotheses

authors： Ozdemir F,Ari A,Kilcik MH,Hanbay D,Sahin I

更新日期：2020-10-01 00:00:00

abstract：:Atherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that t...

journal_title：Medical hypotheses

authors： Nesnawy S,Tolba K,Roshdy I,Abdel Kader M

更新日期：2020-02-01 00:00:00