Abstract:
:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuitive. However, carbon dioxide stimulates the chemosensitive area of the medulla, known as the central respiratory chemoreceptor, which activates the respiratory groups of neurones in the brainstem and stimulates inspiration thereby initiating oxygen intake during normal breathing. This vital initiation of normal breathing is via a reduction in the pH of the cerebrospinal fluid and the medullary interstitial fluid. We hypothesise that in cases of type I respiratory failure in which the PaCO2 is low, administration of carbon dioxide by inhalation would stimulate the respiratory groups of brainstem neurones and facilitate breathing, which would be of therapeutic value. Preliminary clinical evidence in favour of this hypothesis is presented and we recommend that a formal randomised study be carried out.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Julu POO,Shah M,Monro JA,Puri BKdoi
10.1016/j.mehy.2017.11.010subject
Has Abstractpub_date
2018-01-01 00:00:00pages
101-104eissn
0306-9877issn
1532-2777pii
S0306-9877(17)31090-3journal_volume
110pub_type
杂志文章abstract::Schizophrenia has a polygenic mode of inheritance and an estimated heritability of over 80%, but success in understanding its genetic underpinnings to date has been modest. Unlike in trinucleotide neurodegenerative disorders, the phenomenon of genetic anticipation observed in schizophrenia or bipolar disorder has not ...
journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.11.045
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2004.02.010
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.08.027
更新日期:2010-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.03.031
更新日期:2012-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.06.012
更新日期:2013-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90080-a
更新日期:1993-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90192-9
更新日期:1996-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2012-01-01 00:00:00