Enhancement of noncoronary collateral circulation: the hypothesis of an alternative treatment for ischemic heart disease.

abstract：:Most cancer cells differ from normal cells in that they show higher beta-glucuronidase activity and lower pH of their cytoplasm. Anti-cancer drugs can be designed which take advantage of these gradients to deliver maximal toxicity to tumors and minimal toxicity to normal tissue. Many design criteria are suggested here...

journal_title：Medical hypotheses

authors： Rubin DM,Rubin EJ

更新日期：1980-01-01 00:00:00

abstract：:Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...

journal_title：Medical hypotheses

authors： Xu C,Liu W,Wang Y,Chen Z,Ji Y

更新日期：2009-02-01 00:00:00

abstract：:Many of the movement disorders seen in psychiatric patients are determined, in large part, by the dynamic balance of dopamine and acetylcholine in the basal ganglia. Gamma aminobutyric acid has effects on various neurotransmitters in the brain including dopamine and acetylcholine and is therefore relevant to a discuss...

journal_title：Medical hypotheses

authors： Menza M

更新日期：1988-12-01 00:00:00

abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...

journal_title：Medical hypotheses

authors： Levy M,Ehrenfeld M,Gallily R,Eliakim M

更新日期：1981-01-01 00:00:00

abstract：:The DSM is not brain-related and is thus unable to relate clinical assessments to putative brain disturbances. 'Clinical brain profiling' (CBP) involves the rearrangement of clinical findings to assess the relevant disturbances in brain dynamics. CBP has three major pathological dimensions, (1) disorders of basic brai...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2009-08-01 00:00:00

abstract：:The clinical syndrome of hypoxic ischemic encephalopathy (HIE) which occurs in association with birth asphyxia, is thought to represent a reperfusion injury consequent upon the generation of cytotoxic oxygen derived free radicals. It has recently been suggested that resuscitation of asphyxiated infants with unrestrict...

journal_title：Medical hypotheses

authors： Ballot DE,Rothberg AD,Davies VA,Smith J,Kirsten G

更新日期：1993-10-01 00:00:00

abstract：:The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...

journal_title：Medical hypotheses

authors： Milder DG

更新日期：2006-01-01 00:00:00

abstract：:Fissured tongue (FT) is a condition frequently seen in the general population. Clinically, FT is characterized by grooves that vary in depth and are noted along the dorsal and/or dorsolateral aspects of the tongue. Furthermore, FT presents many enlarged, smooth filiform papillae and subepithelial inflammatory infiltra...

journal_title：Medical hypotheses

authors： Järvinen J,Mikkonen JJ,Kullaa AM

更新日期：2014-06-01 00:00:00

abstract：:Preliminary reports have demonstrated that anterior nucleus thalamus high-frequency electrical stimulation (ANT-HFS) is an effective treatment for patients who suffer from medically refractory epilepsy. However, its extensive application has been hampered by the high cost and the unpredictable outcome before the opera...

journal_title：Medical hypotheses

authors： Yan N,Chen N,Lu J,Wang Y,Wang W

更新日期：2013-09-01 00:00:00

abstract：:The interstitial space (ISS) can be thought of as an organ of translocation. Defined in this way the concentration of any substance in the ISS is equal to the ratio of an input to a clearance function. When substances accumulate, there is a disturbance of one or both functions. The three phase anatomy of the ISS give ...

journal_title：Medical hypotheses

authors： Katz MA

更新日期：1980-09-01 00:00:00

abstract：:Bovine serum albumin and human serum transferrin modified by the water soluble carbodiimides N-ethyl-N'-(3-dimethyl propylamino) carbodiimide (CDI) or N-ethyl-N'-(3-trimethyl propylammonium) carbodiimide (Me+CDI) to yield N-acylurea proteins bind pBR322 DNA reversibly showing electrostatic and non-electrostatic compon...

journal_title：Medical hypotheses

authors： Ariatti M,Hawtrey AO

更新日期：1987-09-01 00:00:00

abstract：:The hypothesis of the evolutionary origin of bipolar disorder (EOBD) synthesized ideas about the biological clock and seasonal shifts in mood (Rosenthal, Wehr) with theorizing that bipolar disorder descends from a pyknic (compact, cold-adapted) group (Kretchmer). The hypothesis suggested that bipolar behaviors evolved...

journal_title：Medical hypotheses

authors： Sherman JA

更新日期：2012-01-01 00:00:00

abstract：:The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...

journal_title：Medical hypotheses

authors： Lim D,Flicker L,Dharamarajan A,Martins RN

更新日期：2003-06-01 00:00:00

abstract：:The high rate of mutation which is inherent in reverse transcription of the HIV genome is a result of the lack of proof-reading function of the reverse transcriptase enzyme. This has allowed the HIV virus to develop resistance to multiple antiviral agents. It may be possible to use this viral property to advantage by ...

journal_title：Medical hypotheses

authors： Peasley K

更新日期：2000-11-01 00:00:00

abstract：:We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extr...

journal_title：Medical hypotheses

authors： Hajek D,Kolar P,Maini PK,Starha P

更新日期：2005-01-01 00:00:00

abstract：:Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder (ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In the present article, we hypothesize that ADHD, TS, and RLS may be part of a spectrum, and that iron deficiency contributes to the pathophysio...

journal_title：Medical hypotheses

authors： Cortese S,Lecendreux M,Bernardina BD,Mouren MC,Sbarbati A,Konofal E

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...

journal_title：Medical hypotheses

authors： Damar U,Gersner R,Johnstone JT,Schachter S,Rotenberg A

更新日期：2017-02-01 00:00:00

abstract：:Parkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson's disease usi...

journal_title：Medical hypotheses

authors： Yaman O,Ertam F,Tuncer T

更新日期：2020-02-01 00:00:00

abstract：:Is sleep especially beneficial in times of illness? Despite the widespread use of hypnotics, the medical position on this question is equivocal, for hospital practices seem rarely designed to encourage maximum sleeping. Sleep promotion is defined as the arrangement of conditions so that patients can achieve as much sl...

journal_title：Medical hypotheses

authors： Cumming G

更新日期：1984-09-01 00:00:00

abstract：:The aim of this study is to identify a possible function of Active Sleep (AS), also known as Rapid Eye Movement Sleep (REM) in humans, as a protective state during early Central Nervous System (CNS) development. Previous research suggest pharmacological agents that inhibit high levels of neuronal activity in the CNS (...

journal_title：Medical hypotheses

authors： Morrissey MJ,Duntley SP,Anch AM,Nonneman R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...

journal_title：Medical hypotheses

authors： Anderson G,Maes M,Berk M

更新日期：2012-06-01 00:00:00

abstract：:The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal ...

journal_title：Medical hypotheses

authors： Szabo AJ

更新日期：2019-01-01 00:00:00

abstract：:Genetic and environmental influences are both known to be causal factors in the development and maintenance of obesity. Stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting increased glucocorticoid exposure are known to be important pathophysiological mechanisms in the deve...

journal_title：Medical hypotheses

authors： Mutschler J,Kiefer F

更新日期：2011-03-01 00:00:00

abstract：:IGF-I acts on vascular endothelium to activate nitric oxide synthase, thereby promoting vascular health; there is reason to believe that this protection is especially crucial to the cerebral vasculature, helping to ward off thrombotic strokes. IGF-I may also promote the structural integrity of cerebral arteries, there...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2003-09-01 00:00:00

abstract：:Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interpla...

journal_title：Medical hypotheses

authors： Fedorko ME

更新日期：1999-08-01 00:00:00

abstract：:A localized graft-versus-host reaction was used to assess the cellular immunity of mice supporting progressive growth of an allogeneic tumor. It was found that early in tumor development anti-tumor-cellular-mediated immunity was hyper-responsive, and that adherent phagocytic cells isolated from the neoplasm would inhi...

journal_title：Medical hypotheses

authors： Parks RC

更新日期：1979-09-01 00:00:00

abstract：:The symptom spectra of several 'popular press' diagnoses are examined and compared to Diagnostic and Statistical Manual of Mental Disorders-IIIR criteria for somatization disorder, depression, and generalized anxiety disorder. While there is much overlap, there are clear distinctions, and these psychiatric terms do no...

journal_title：Medical hypotheses

authors： Elks ML

更新日期：1996-04-01 00:00:00

abstract：:Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

journal_title：Medical hypotheses

authors： Mladina R,Skitarelić N

更新日期：2010-10-01 00:00:00

abstract：:Vaccines are effective in preventing disease by stimulating the immune system and sustaining an immune response towards eradication of pathogens and diseased cells. However, designing successful vaccines is not always straightforward. For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated...

journal_title：Medical hypotheses

authors： Ilag LL

更新日期：2011-10-01 00:00:00

abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

journal_title：Medical hypotheses

authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

更新日期：2018-08-01 00:00:00