Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.

abstract：:Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality. Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evol...

journal_title：Medical hypotheses

authors： Hála M

更新日期：2007-01-01 00:00:00

abstract：:The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...

journal_title：Medical hypotheses

authors： Baggot MG

更新日期：1991-06-01 00:00:00

abstract：:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...

journal_title：Medical hypotheses

authors： Pallotti C,Pettazzoni P,Slawomirski MR

更新日期：1995-05-01 00:00:00

abstract：:Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes. Increased production of IL-17 has been linked to the induction of cytokines, chemokines and adhesion molecules in various cell types, effects that likely contribute to a number of inflammatory diseases including rheumatoid arthri...

journal_title：Medical hypotheses

authors： Csiszar A,Ungvari Z

更新日期：2004-01-01 00:00:00

abstract：:Proteins are assumed to contain all the information necessary for unambiguous folding and specific interaction with each other. However, ab initio structure prediction is often not successful because the amino acid sequence itself is simply not sufficient to guide between endless folding possibilities. It seems to be ...

journal_title：Medical hypotheses

authors： Biro JC

更新日期：2006-01-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...

journal_title：Medical hypotheses

authors： Guinet E,Mimaud V,Rossignol P,Hameau L,Benboudjema L,Jasmin C,Tovey MG,Bélec L,Lang MC

更新日期：2003-02-01 00:00:00

abstract：:The title enzyme, peptidylglycine alpha-hydroxylating monooxygenase (PHM), is essential to the in vivo generation of a wide variety of physiologically significant alpha-amidated peptide hormones from the corresponding C-terminal glycine-extended prohormones. Over a 20-year period of time a massive amount of experiment...

journal_title：Medical hypotheses

authors： Owen TC,Merkler DJ

更新日期：2004-01-01 00:00:00

abstract：:A general theory of neural circuitry is proposed wherein neural impulses travel in a continuous circuit from the brain to the extremities and back to the brain. At the extremities the impulse may be modified by the environment there. At the spinal column the return signal is compared with the outgoing signal and the a...

journal_title：Medical hypotheses

authors： Kingham DJ

更新日期：1994-05-01 00:00:00

abstract：:Increased level of oxalates in urine and plasma can be attributed to endogenous overproduction, increased ingestion or excessive intestinal absorption. When a supersaturation status is reached, oxalates combine with calcium and crystallize to form 80% of the urinary stones. Several cardiovascular diseases such as coro...

journal_title：Medical hypotheses

authors： Arafa A,Eshak ES,Iso H

更新日期：2020-04-01 00:00:00

abstract：:Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are w...

journal_title：Medical hypotheses

authors： Dalton K

更新日期：1990-04-01 00:00:00

abstract：:Cerebral ischemia is still one of the most confusing and enigmatic neurological disorders with least understood injuries. The EEG measures have been traditionally used to detect residual neural dysfunctions after cerebral ischemia although having several shortcomings, yielding controversial and inconsistent results. I...

journal_title：Medical hypotheses

authors： Bhattacharya P,Pandey AK,Paul S,Patnaik R

更新日期：2013-09-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) has gained prominence since 1988 and a substantial amount of research has been done in this domain. However, it is still regarded as a controversial condition. Moreover, most of the symptoms of CFS itself are non-specific, occurring in many illnesses; some of the symptoms are also common...

journal_title：Medical hypotheses

authors： Van Hoof E,Cluydts R,De Meirleir K

更新日期：2003-07-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine foramen. Over l...

journal_title：Medical hypotheses

authors： Kairo AK,Kumar R,Sharma SC

更新日期：2020-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a new therapeutic approach for the treatment of malignant tumors. Hyperbaric oxygen (HBO(2)) shows beneficial effects in various modalities of cancer interventions. Tumor cells tend to accumulate large amount of iron. There is interaction between tissue content of oxygen, iron, free radic...

journal_title：Medical hypotheses

authors： Al-Waili NS,Butler GJ

更新日期：2006-01-01 00:00:00

abstract：:There are many observations regarding the behaviour of melanoma which points away from sunshine as the main cause of this tumour. Incidence data shows that the increase is mostly seen for thin melanomas which cannot be attributed to sun exposure but increasing screening over the last 20 years. Melanoma behaves in a si...

journal_title：Medical hypotheses

authors： Bataille V

更新日期：2013-11-01 00:00:00

abstract：:Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative diseases of oral mucosa affecting an estimate of 20% of the world's population. Majority of the people affected by RAS are under 30 years of age. RAS is located on the lining (non-keratinized) oral mucosa, i.e. buccal mucosa, lateral side of the tongue,...

journal_title：Medical hypotheses

authors： Pärssinen M,Jäsberg H,Mikkonen JJW,Kullaa AM

更新日期：2021-01-01 00:00:00

abstract：:Dupuytren's disease is a pathological condition of the palmar fascia characterized by the formation of contractile disease cords that result in permanent finger contracture. This condition is believed to progress from a myofibroblast-rich nodule in the early clinical stages of the disease to a contractile disease cord...

journal_title：Medical hypotheses

authors： Vi L,Gan BS,O'Gorman DB

更新日期：2010-03-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00

abstract：:We develop here the hypothesis that polycystic kidneys (PCK) may maintain, to a certain extent, the ability to perform endocrine functions. We know that patients with adult polycystic kidney disease (APCKD) produce more erythropoietin and maintain a higher hematocrit than patients with other primary diseases of the ki...

journal_title：Medical hypotheses

authors： Rotellar C,Gelfand MC

更新日期：1989-09-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...

journal_title：Medical hypotheses

authors： Elkadi OA,Abdelbasset M

更新日期：2016-04-01 00:00:00

abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

journal_title：Medical hypotheses

authors： Altschuler E

更新日期：1999-07-01 00:00:00

abstract：:Foster found areas with the highest incidence of SIDS in USA in 1983-1984 coincided with the highest areas recorded with the highest incidence of goitre in First World War troops (1). Reid compared the two populations described as having the highest incidence of SIDS worldwide. Both were selenium deficient areas (King...

journal_title：Medical hypotheses

authors： Reid G,Tervit H

更新日期：1994-04-01 00:00:00

abstract：:Cognitive plasticity, a developmental trait that promotes acquisition of complex skills such as language or playing musical instruments, diminishes substantially during puberty. The loss of plasticity has been attributed to surge of sex steroids during adolescence, but the phenomenon remains poorly understood. We hypo...

journal_title：Medical hypotheses

authors： Yun AJ,Bazar KA,Lee PY

更新日期：2004-01-01 00:00:00

abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

journal_title：Medical hypotheses

authors： Cohen SR,Cohen EP

更新日期：2013-02-01 00:00:00

abstract：:Recent studies have shown that increased hepatic gluconeogenesis is the predominant contributor to fasting hyperglycemia - the hallmark of type 2 diabetes. Although it has been known for a long time that over-supply of fat is able to stimulate gluconeogenesis both in-vitro and in-vivo, neither the leading substrate no...

journal_title：Medical hypotheses

authors： Song S

更新日期：2000-05-01 00:00:00

abstract：:The interstitial space (ISS) can be thought of as an organ of translocation. Defined in this way the concentration of any substance in the ISS is equal to the ratio of an input to a clearance function. When substances accumulate, there is a disturbance of one or both functions. The three phase anatomy of the ISS give ...

journal_title：Medical hypotheses

authors： Katz MA

更新日期：1980-09-01 00:00:00

abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:Vasogenic brain edema occurs as a result of a diverse spectrum of central nervous system pathology. The fundamental physiologic abnormality of vasogenic brain edema is an increase in cerebral capillary permeability. It is hypothesized that the recent development of new, potent, synthetic vasopressin antagonists will m...

journal_title：Medical hypotheses

authors： Weinand ME

更新日期：1988-05-01 00:00:00