Sexual arousal and rhythmic synchronization: A possible effect of vasopressin.

abstract：:Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...

journal_title：Medical hypotheses

authors： Offringa-Hup A

更新日期：2020-04-01 00:00:00

abstract：:Transcendental mediation (TM) is a stylized form of physical and mental relaxation which is associated with changes in the secretion and release of several pituitary hormones. The hormonal changes induced by TM mimic the effects of the inhibitory neurotransmitter gamma aminobutyric acid (GABA). It is hypothesized that...

journal_title：Medical hypotheses

authors： Elias AN,Wilson AF

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

journal_title：Medical hypotheses

authors： Tavakol S

更新日期：2014-12-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00

abstract：:Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations...

journal_title：Medical hypotheses

authors： Robertson DS

更新日期：2005-01-01 00:00:00

abstract：:Educational expansion in western countries has been achieved mainly by adding years to full-time education; however, this process has probably reduced efficiency. Sooner or later, efficiency must improve, with a greater educational attainment per year. Future societies will probably wish more people to study science t...

journal_title：Medical hypotheses

authors： Charlton BG

更新日期：2006-01-01 00:00:00

abstract：:The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...

journal_title：Medical hypotheses

authors： Asencio JM,Vaquero J,Olmedilla L,García Sabrido JL

更新日期：2013-05-01 00:00:00

abstract：:Numerous studies indicate that aberrant amyloid precursor protein metabolism, elevated peroxidative damage, depressed energy metabolism and altered calcium homeostasis are four pivotal deleterious factors in the pathogenesis of Alzheimer's disease. Cumulative evidence further suggests that these four factors are intim...

journal_title：Medical hypotheses

authors： Ying W

更新日期：1996-05-01 00:00:00

abstract：:This article proposes the hypothesis that allantois is the anatomical homologue of bursa of Fabricius in mammalia. This hypothesis is based on immunohistochemical study of sections from hematopoietic organs of three fetuses with cloacal exstrophy. In the complex maldevelopment of cloacal exstrophy the common features ...

journal_title：Medical hypotheses

authors： Zarabi CM

更新日期：1990-06-01 00:00:00

abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

journal_title：Medical hypotheses

authors： Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

更新日期：2020-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) therapy has emerged as a potent therapeutic strategy to improve myocardial infarction. However MSCs therapy encounters a few obstacles regarding the poor viability of the transplanted cells. Therefore, it is important to explore a strategy to enhance post-transplanted MSC viability. To ov...

journal_title：Medical hypotheses

authors： Sharifi AM,Mottaghi S

更新日期：2012-04-01 00:00:00

abstract：:Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers. Copper has potent anti-fungal an...

journal_title：Medical hypotheses

authors： Borkow G,Zatcoff RC,Gabbay J

更新日期：2009-12-01 00:00:00

abstract：:The characteristic insoluble, senile (neuritic) plaques found extracellularly in brains of patients with Alzheimer's disease (AD) contain the fibrillar form of beta-amyloid (Abeta42). A substantial proportion of autopsied elderly brains have demonstrated DNA evidence of herpes simplex virus type 1 (HSV-1) infiltration...

journal_title：Medical hypotheses

authors： Kammerman EM,Neumann DM,Ball MJ,Lukiw W,Hill JM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...

journal_title：Medical hypotheses

authors： Tilman V

更新日期：2016-01-01 00:00:00

abstract：:A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial...

journal_title：Medical hypotheses

authors： Zhang L,Liang S,Zhang G,Kang X

更新日期：2013-11-01 00:00:00

abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...

journal_title：Medical hypotheses

authors： Lu DY,Chen XL,Ding J

更新日期：2007-01-01 00:00:00

abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...

journal_title：Medical hypotheses

authors： Beaugerie L,Langholz E,Nyboe-Andersen N,Pigneur B,Sokol H,ECCO Epicom.

更新日期：2018-06-01 00:00:00

abstract：:Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...

journal_title：Medical hypotheses

authors： Castelao JE,Gago-Dominguez M

更新日期：2008-01-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:In attempts to develop a rational anticancer strategy the same homologous tissue in 3 conditions were used side by side as targets: normal epidermis of the mouse back. Tween 60R-provoked benign epidermal hyperplasia, and carcinogen-provoked malignant condition. In contrast to the highest tolerated doses of the cytosta...

journal_title：Medical hypotheses

authors： Setälä K

更新日期：1982-03-01 00:00:00

abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...

journal_title：Medical hypotheses

authors： Saltuklaroglu T,Dayalu VN,Kalinowski J

更新日期：2002-01-01 00:00:00

abstract：:Ischaemic stroke ranks among the most important causes of death and disability in developed countries. Abnormal lipid metabolism is among the several factors that have a role in the pathogenesis of atherosclerosis. We hypothesize that the decreased resistance of low-density lipoproteins against oxidative stress is an ...

journal_title：Medical hypotheses

authors： Bereczki D,Balla G,Csiba L,Jeney V,Valikovics A,Magyar T,Balla J

更新日期：2001-06-01 00:00:00

abstract：:A search for control mechanisms involving embryonic genes is explored reviewing a variety of subject areas including, a) the methylation status of DNA and the globin gene, b) ethionine and steroid effects on expression of embryonic genes, c) alpha-fetoprotein gene activity induced by carcinogens and in hepatomas. Also...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1993-05-01 00:00:00

abstract：:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause el...

journal_title：Medical hypotheses

authors： Jennings T

更新日期：1990-08-01 00:00:00

abstract：:The author reviews the criticism aimed at medical education and suggests that its shortcomings could be corrected by modifying the curriculum so that irrelevant material is eliminated and replaced in part with the humanities. ...

journal_title：Medical hypotheses

authors： Prioreschi P

更新日期：1980-05-01 00:00:00

abstract：:Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-06-01 00:00:00

abstract：:Normally, the transport of allergens through the intestinal epithelia to the blood is limited. It is hypothesised that if these compounds arrive in the blood circulation, they must percolate through the epithelial cell layer. Thus, food allergy (and thus atopic eczema) implies an increased intercellular leakage of the...

journal_title：Medical hypotheses

authors： Bongaerts GP,Severijnen RS

更新日期：2005-01-01 00:00:00

abstract：:Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...

journal_title：Medical hypotheses

authors： Arbesman H

更新日期：1999-07-01 00:00:00

abstract：:Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

journal_title：Medical hypotheses

authors： Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

更新日期：2016-10-01 00:00:00

abstract：:It has been shown by Elmets et al. (1) that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certai...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1986-04-01 00:00:00