Medical education, irrelevancy and the humanities.

abstract：:IGF-I acts on vascular endothelium to activate nitric oxide synthase, thereby promoting vascular health; there is reason to believe that this protection is especially crucial to the cerebral vasculature, helping to ward off thrombotic strokes. IGF-I may also promote the structural integrity of cerebral arteries, there...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2003-09-01 00:00:00

abstract：:Cognitive plasticity, a developmental trait that promotes acquisition of complex skills such as language or playing musical instruments, diminishes substantially during puberty. The loss of plasticity has been attributed to surge of sex steroids during adolescence, but the phenomenon remains poorly understood. We hypo...

journal_title：Medical hypotheses

authors： Yun AJ,Bazar KA,Lee PY

更新日期：2004-01-01 00:00:00

abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...

journal_title：Medical hypotheses

authors： Huang Y,Liu A,Liu L,Wang B,Liang G

更新日期：2020-02-01 00:00:00

abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...

journal_title：Medical hypotheses

authors： Visser JJ,Hoekman K

更新日期：1994-11-01 00:00:00

abstract：:Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

journal_title：Medical hypotheses

authors： Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:This study investigated whether or not the anesthetic effect of ketamine in rats is dependent on adrenal gland hormones. The study was performed on two main rat groups, intact and adrenalectomized. Rat were divided into subgroups and given appropriate doses of ketamine, metyrapone or metyrosine. Durations of anesthesi...

journal_title：Medical hypotheses

authors： Aksoy M,Ince I,Ahiskalioglu A,Dostbil A,Celik M,Turan MI,Cetin N,Suleyman B,Alp HH,Suleyman H

更新日期：2014-07-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to have a higher incidence of cancer. It is suggested that several factors, including hyperinsulinemia, dyslipidemia, raised estrogen levels, chronic inflammation, and reduced apoptosis are responsible for this association. However, in this paper we propose t...

journal_title：Medical hypotheses

authors： Mravec B,Tibensky M

更新日期：2020-01-01 00:00:00

abstract：:Non-union after bone fracture is rather common with an increasing frequency of incidence rate due to poorly treated early operations, among which the mechanism of atrophic non-union remains unclear. Previous opinions showed that impaired blood supply of affected limbs might mostly contribute to the atrophic non-union,...

journal_title：Medical hypotheses

authors： Sun D,Yuan D,Zhang X

更新日期：2011-07-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothes...

journal_title：Medical hypotheses

authors： Hristova MG

更新日期：2013-10-01 00:00:00

abstract：:The CoV-19 infection appears to be unusual among patients with type 1 Diabetes Mellitus, although they are considered a fragile population. We think that this in part due to the peculiar immune condition that leads to the destruction of the Beta cells. ...

journal_title：Medical hypotheses

authors： Tatti P,Tonolo G,Zanfardino A,Iafusco D

更新日期：2020-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a major cause of morbidity and mortality among older individuals. Although the causes of Parkinson's disease are multifactorial, considerable evidence indicates that elevated labile iron in the substantia nigra pars compacta plays an important role in producing oxyradicals which subsequentl...

journal_title：Medical hypotheses

authors： Edwin Shackelford R,Manuszak RP,Heard SC,Link CJ,Wang S

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis and the acquisition of an angiogenic phenotype is important for cancer cell proliferation. Copper in an essential trace element that participates in many enzymatic complexes like the cytochrome c, superoxide dismutase and lysyl oxidase and it is involved in processes, like embryogenesis, growth, angiogene...

journal_title：Medical hypotheses

authors： Antoniades V,Sioga A,Dietrich EM,Meditskou S,Ekonomou L,Antoniades K

更新日期：2013-12-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：:Periodontitis significantly decreases survival in hemodialysed patients with end stage renal disease (ESRD). Periodontitis-related microorganisms spreading into the bloodstream are thought to impair blood rheological parameters - for example, increasing whole blood viscosity, aggregating blood elements, and decreasing...

journal_title：Medical hypotheses

authors： Sedý J,Horká E,Foltán R,Spacková J,Dusková J

更新日期：2010-02-01 00:00:00

abstract：:'Electrohypersensitivity' is often explained as a psychological syndrome. Our modern environment contains a lot of different substances and some of them are toxic. Mycotoxins are types of toxins that are biologically very active and that affect living organisms. Mycotoxins and fungi capable of producing toxins have be...

journal_title：Medical hypotheses

authors： Anttila K

更新日期：2000-09-01 00:00:00

abstract：:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocul...

journal_title：Medical hypotheses

authors： Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

更新日期：2020-11-01 00:00:00

abstract：:The physical interaction between the red blood cells and colloidal silica leads to hemolysis. We propose that the nature of the red-cell elimination as the result of this interaction is not random. As the negatively charged silica particles at the physiological conditions electrostatically react with the positive site...

journal_title：Medical hypotheses

authors： Gerashchenko BI,Gerashchenko II,Pantazis CG

更新日期：1996-07-01 00:00:00

abstract：:Chronic Interstitial Nephritis in Agricultural Communities (CINAC) continues to attract controversy in the scientific community. It was previously known as Chronic Kidney Disease of Unknown Etiology (CKDu) and is not associated with the common aetiological factors such as diabetes. There is general acceptance that it ...

journal_title：Medical hypotheses

authors： Rodrigo C,Nawarathne P,Jayasinghe S

更新日期：2021-01-01 00:00:00

abstract：:Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

journal_title：Medical hypotheses

authors： Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2004-01-01 00:00:00

abstract：:As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...

journal_title：Medical hypotheses

authors： Miric D,Hallet-Mathieu AM,Amar G

更新日期：2005-01-01 00:00:00

abstract：:In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC. We hypothesize t...

journal_title：Medical hypotheses

authors： Manerio E,Rodas VL,Costas E,Hernandez JM

更新日期：2008-01-01 00:00:00

abstract：:Along with oxygen, glucose is an essential macronutrient for most cells, a source of carbons for biosynthesis and energy. However, alongside this indispensable role for cell survival and growth, glucose is intrinsically toxic by reacting with primary amines such as lysine in proteins in a non-enzymatic glycation proce...

journal_title：Medical hypotheses

authors： Szwergold BS

更新日期：2005-01-01 00:00:00

abstract：:We present a plausible and powerful explanation for nicotine addiction that is consistent with recent findings. Sleep apnea, the periodic cessation of breathing during sleep, may be responsible for the addictive nature of nicotine. The main symptoms of sleep apnea are somnolence and obesity. Nicotine has been shown to...

journal_title：Medical hypotheses

authors： Schrand JR

更新日期：1996-12-01 00:00:00

abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...

journal_title：Medical hypotheses

authors： Singer P,Richter-Heinrich E

更新日期：1991-09-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...

journal_title：Medical hypotheses

authors： Elkadi OA,Abdelbasset M

更新日期：2016-04-01 00:00:00

abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

journal_title：Medical hypotheses

authors： Cohen SR,Cohen EP

更新日期：2013-02-01 00:00:00

abstract：:Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA),...

journal_title：Medical hypotheses

authors： Fischer KM

更新日期：1998-09-01 00:00:00