The association between vitamin deficiency and otolaryngologic diseases: A therapeutic target.

Abstract:

:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large number of clinical manifestations including xerophthalmia, nyctalopia, hyperpigmentation, vitiligo, jaundice, megaloblastic anemia, glossitis, scurvy, stroke, cancer, coronary heart disease, Alzheimer's disease, multiple sclerosis and Parkinson's disease. In recent years, more and more researches have focused on the relationship between vitamin family and otorhinolaryngologic diseases. This review will summarize the current knowledge of vitamin family and vitamin-mediated regulating role in those related otorhinolaryngologic diseases.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Huang Y,Liu A,Liu L,Wang B,Liang G

doi

10.1016/j.mehy.2019.109448

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

109448

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(19)31089-8

journal_volume

135

pub_type

杂志文章,评审
  • Can the 'yin and yang' BDNF hypothesis be used to predict the effects of rTMS treatment in neuropsychiatry?

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2008.02.011

    authors: Brunoni AR,Boggio PS,Fregni F

    更新日期:2008-08-01 00:00:00

  • Does latitude as a zeitgeber affect the course of bipolar affective disorder?

    abstract:BACKGROUND:Bipolar disorder (BD) is characterized by recurrent episodes of mood dysregulations and depression is considered as the most frequent form of relapse. However, there is some evidence that in tropical countries, the course might be different with fewer depressive episodes. This study aims to examine the frequ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.06.017

    authors: Narayanaswamy JC,Moily N,Kubendran S,Reddy YC,Jain S

    更新日期:2014-09-01 00:00:00

  • Sensory gating deficits, pattern completion, and disturbed fronto-limbic balance, a model for description of hallucinations and delusions in schizophrenia.

    abstract::Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.03.054

    authors: Javanbakht A

    更新日期:2006-01-01 00:00:00

  • Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.

    abstract::An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(02)00253-0

    authors: Lin YP,Cheng TJ

    更新日期:2002-08-01 00:00:00

  • A theory of marks and mind: the effect of notational systems on hominid brain evolution and child development with an emphasis on exchanges between mothers and children.

    abstract::A model of human language requires a theory of meaningful marks. Humans are the only species who use marks to think. A theory of marks identifies children's scribbles as significant behavior, while hypothesizing the importance of rotational systems to hominid brain evolution. By recognizing the importance of children'...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2004.09.002

    authors: Sheridan SR

    更新日期:2005-01-01 00:00:00

  • Are B lymphocytes involved in allograft/tumor rejection and GVH?

    abstract::Several earlier observations by us and other investigators led us to propose a thesis that B lymphocytes, when activated by a virus, allo-antigen or bacterial protein would enter into effector arm of the immune response and cause allograft and tumor rejection or GVH-type of lesion in immunosuppressed animals. These ef...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(90)90071-l

    authors: Krishnan G

    更新日期:1990-05-01 00:00:00

  • Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy?

    abstract::Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome that is estimated to affect 4-8 million US adults. The exact molecular mechanisms underlying this illness remain unclear, rendering most clinical treatment and management techniques relatively ineffective. It is now known that abnormalities in both noci...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.01.052

    authors: Recla JM,Sarantopoulos CD

    更新日期:2009-08-01 00:00:00

  • Centenarian scientists: an unusual cluster newly formed in the 20th century.

    abstract::From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章

    doi:10.1054/mehy.2001.1480

    authors: Sri Kantha S

    更新日期:2001-12-01 00:00:00

  • Black bile: are elevated monoamines an etiological factor in some cases of major depression?

    abstract::It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.03.023

    authors: Fitzgerald PJ

    更新日期:2013-06-01 00:00:00

  • Treatment of trauma with lithium to forestall the development of posttraumatic stress disorder by pharmacological induction of a mild transient amnesia.

    abstract::Posttraumatic stress disorder (PTSD) is a severe anxiety disorder that develops after exposure to trauma. Symptoms include persistent reexperiencing, persistent avoidance, persistent numbing, and persistent hyperarousal. Subsequent to trauma exposure, the onset of symptoms of an acute stress reaction can typically dev...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.02.017

    authors: Wallace J

    更新日期:2013-06-01 00:00:00

  • Differences between responsive and intractable chronic lymphocytic leukemia.

    abstract::About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(90)90001-u

    authors: Schrek R

    更新日期:1990-02-01 00:00:00

  • Tannins, salivary proline-rich proteins and oesophageal cancer.

    abstract::No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90060-6

    authors: Warner TF,Azen EA

    更新日期:1988-06-01 00:00:00

  • Cancer prevention and therapy.

    abstract::Based on a consideration of biochemical mechanisms, rational methods for the prevention of cancer and for its positive regression are presented. It is demonstrated that the means employed are fundamentally opposed so that if the preventive method were to be used after the onset of cancer, it would only accelerate its ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90030-x

    authors: Duchesne J

    更新日期:1981-04-01 00:00:00

  • Of schizophrenia, pruning, and epigenetics: a hypothesis and suggestion.

    abstract::One area of relative agreement in schizophrenic research is that there is grey matter volume deficit in various cortical areas associated with this illness. One theory attempting to explain this involves an exaggerated action of the normal CNS pruning process. Various aspects of this process were discussed along with ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.03.038

    authors: Rosenthal R

    更新日期:2011-07-01 00:00:00

  • Melatonin as a principal component of red light therapy.

    abstract::Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y Acad Sci 1996;786:362-78]. Moreover, melatonin has been shown to ret...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.12.041

    authors: Yeager RL,Oleske DA,Sanders RA,Watkins JB 3rd,Eells JT,Henshel DS

    更新日期:2007-01-01 00:00:00

  • Vulvodynia and fungal association: a preliminary report.

    abstract::Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2013.04.043

    authors: Ventolini G,Gygax SE,Adelson ME,Cool DR

    更新日期:2013-08-01 00:00:00

  • Over-the-counter nicotine replacement therapy for everyone: is it the best solution?

    abstract::The persistent use of different forms of nicotine replacement therapy (NRT) is an under-investigated issue in medical research. While the data concerning the proportion of long-term users in the population of total NRT users seems reassuring at first glance, we must recognize that the small relative numbers (proportio...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.08.045

    authors: Dome P

    更新日期:2011-12-01 00:00:00

  • From terra firma to terra plana--danger is shaking the foundations: deconstructing the 'immune system'.

    abstract::The paradigm of an immune system presumes that a system arose specifically to combat infection -- hence its name. This paradigm gained credibility with the discovery of antibodies and anamnestic immunity, even though these are relatively late arrivals in evolution. Another presumption has been that thymus-dependent T ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1997.0645

    authors: Cunliffe J

    更新日期:1999-03-01 00:00:00

  • Permanent His bundle pacing to replace biventricular pacing for cardiac resynchronization therapy.

    abstract:INTRODUCTION:Cardiac resynchronization therapy (CRT) or biventricular pacing (BIVP) has become a common procedure for the treatment of ventricular dyssynchrony in patients with heart failure, particularly in those with bundle branch block patterns (QRS durations >150ms) on the electrocardiogram (ECG). However, a large ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.09.026

    authors: Scherlag BJ,Papaila A

    更新日期:2017-11-01 00:00:00

  • Speckle tracking technology for quantifying lung sliding.

    abstract::Ultrasound (US) is gaining recognition as a useful tool for assessing lung physiology and pathology. Yet, currently the skill of performing lung US is taught by experienced operators to novice ones, mainly by recognizing expected patterns. Recognizing the latter may be difficult and subjective. In this hypothesis we p...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2016.04.019

    authors: Dori G,Jakobson DJ

    更新日期:2016-06-01 00:00:00

  • Adding cetuximab to stereotactic radiotherapy for non-small cell lung cancer might reduce local failure rates.

    abstract::Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.01.001

    authors: Nieder C,Andratschke N

    更新日期:2012-04-01 00:00:00

  • A novel promising therapy for skin aging: dermal multipotent stem cells against photoaged skin by activation of TGF-β/Smad and p38 MAPK signaling pathway.

    abstract::Skin photoaging, the most common skin damage, is caused by chronic UV irradiation. It is involved in the reduction, aging and apoptosis of fibroblasts (FBs) as well as the blockage of transforming growth factor-beta (TGF-β)/Smad and p38 mitogen-actived protein kinase (MAPK) signaling pathways. Dermal multipotent stem ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.10.035

    authors: Zhong J,Hu N,Xiong X,Lei Q,Li L

    更新日期:2011-03-01 00:00:00

  • A nucleoside analogue of 2, 4-difluoropyridine has potential as an antiretroviral agent with multiple and unique mechanisms of action, and may be effective against the HIV organism.

    abstract::The high rate of mutation which is inherent in reverse transcription of the HIV genome is a result of the lack of proof-reading function of the reverse transcriptase enzyme. This has allowed the HIV virus to develop resistance to multiple antiviral agents. It may be possible to use this viral property to advantage by ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1077

    authors: Peasley K

    更新日期:2000-11-01 00:00:00

  • Cannabinoid hyperemesis syndrome: A disorder of the HPA axis and sympathetic nervous system?

    abstract::Cannabinoid hyperemesis syndrome (CHS), a variant of cyclic vomiting syndrome, is an enigmatic and challenging clinical disorder. As cannabis legalization, use, and potency has increased worldwide over the past decade, so has the prevalence of CHS. These patients often require acute care and inpatient treatment for re...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.04.018

    authors: Richards JR

    更新日期:2017-06-01 00:00:00

  • Shellfish consumption: a major risk factor for colorectal cancer.

    abstract::In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC. We hypothesize t...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2007.03.041

    authors: Manerio E,Rodas VL,Costas E,Hernandez JM

    更新日期:2008-01-01 00:00:00

  • Diabetes and enterovirus autoimmunity in glacial Europe.

    abstract::The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1997.0663

    authors: Wendorf MA

    更新日期:1999-05-01 00:00:00

  • Expanded (CAG)n, (CGG)n and (GAA)n trinucleotide repeat microsatellites, and mutant purine synthesis and pigmentation genes cause schizophrenia and autism.

    abstract::Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA),...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/s0306-9877(98)90080-9

    authors: Fischer KM

    更新日期:1998-09-01 00:00:00

  • Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.04.013

    authors: Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

    更新日期:2019-06-01 00:00:00

  • Haemopoietic stem cells and basophils.

    abstract::In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(94)90144-9

    authors: Drummond R

    更新日期:1994-09-01 00:00:00

  • Aluminum-containing antacids as a cause of idiopathic Parkinson's disease.

    abstract::The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1997.0701

    authors: Altschuler E

    更新日期:1999-07-01 00:00:00