Tannins, salivary proline-rich proteins and oesophageal cancer.

abstract：:Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of ...

journal_title：Medical hypotheses

authors： Wang JZ,Li L,Pan LL,Chen JH

更新日期：2015-11-01 00:00:00

abstract：:Clinical studies have shown that moderately intense physical activity effectively treats various types of depression. Beneficial effects have been reported in the acute phase of the disease as well as in a long-term perspective. In addition, epidemiological studies have shown that inactivity increases the risk of depr...

journal_title：Medical hypotheses

authors： Stenman E,Lilja A

更新日期：2013-01-01 00:00:00

abstract：:Doppler sonography is used as a routine test for detection of renal artery stenosis (RAS). Although increased peak systolic velocity at the site of the narrowing is a widely accepted method for assessing main renal artery stenosis, tardus parvus phenomenon detected on the downstream blood flow has been used as an alte...

journal_title：Medical hypotheses

authors： Cavalcante Araújo N

更新日期：2019-03-01 00:00:00

abstract：:Although many risk factors influence atherogenesis, LDL appears to play a primary role in this process. In prospective epidemiology, coronary risk increases as LDL cholesterol increases, throughout the entire range of concentrations encountered in healthy humans. Coronary risk is minimal in individuals and populations...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2005-01-01 00:00:00

abstract：:Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss t...

journal_title：Medical hypotheses

authors： Corrigan FM,MacDonald S,Brown A,Armstrong K,Armstrong EM

更新日期：1994-10-01 00:00:00

abstract：:The apparent association of laryngeal cancer with asbestos and possibly other occupational exposures can be accounted for by the hypothesis that chronic vocal abuse peculiar to certain working conditions will act as a promoting factor for active carcinogens found mainly in tobacco smoke. ...

journal_title：Medical hypotheses

authors： Chovil A

更新日期：1981-07-01 00:00:00

abstract：:This paper treats evidence for an increasing recognition of a force with intangible properties in biosystems with special reference to its ability to transport electrons at near 0 degree Kelvin. It is implied that such force, whose demonstration at these temperatures is an experimental contrivance to emphasise its str...

journal_title：Medical hypotheses

authors： Reid BL

更新日期：1995-06-01 00:00:00

abstract：:Fetal death recurrence is an important problem in reproductive health that is poorly understood. Based on preliminary epidemiologic evidence, we propose an "event memory" hypothesis which posits that when fetal death occurs the event is retained (memorized) as a program that is replayed in future pregnancies. We descr...

journal_title：Medical hypotheses

authors： Salihu HM

更新日期：2008-01-01 00:00:00

abstract：:Ebola virus (EBOV) infection is associated with modulation of cytokine expression in infected patients. EBOV has been shown to interact directly with immune cells (at minimum with macrophages and dendritic cells) and modulation of cytokine expression has also been observed in vitro, which is similar to that in vivo. T...

journal_title：Medical hypotheses

authors： Denner J

更新日期：2015-09-01 00:00:00

abstract：:Homeostasis, or the maintenance of constant internal environment in the organism, is disrupted by injury. In this case, pathological defence reactions such as inflammation and healing take place in order to restore it. They succeed if etiological harmful factors are eliminated. In the opposite case, constant injury le...

journal_title：Medical hypotheses

authors： Beranek JT

更新日期：1991-10-01 00:00:00

abstract：:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for pro...

journal_title：Medical hypotheses

authors： Altschuler EL

更新日期：2001-12-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) experience co-morbid illnesses, including cardiovascular disease and retinopathy. Sevelamer hydrochloride (Renagel®); a non-calcium phosphate binder reduces coronary artery and aortic calcification as compared to calcium containing phosphate binders and additionally effects i...

journal_title：Medical hypotheses

authors： Draca N,Lazic R,Simic P,Dumic-Cule I,Luetic AT,Gabric N

更新日期：2013-04-01 00:00:00

abstract：AIMS:To investigate the role of urinary BK polyoma virus (BKPyV) in the pathophysiology and prognosis of patients with painful bladder syndrome/interstitial cystitis (PBS/IC). METHODS:Urine samples were collected from 15 patients with PBS/IC and 8 control patients (with urolithiasis, overactive bladder and benign pros...

journal_title：Medical hypotheses

authors： Van der Aa F,Beckley I,de Ridder D

更新日期：2014-09-01 00:00:00

abstract：:Recent studies confirm that dietary methionine restriction increases both mean and maximal lifespan in rats and mice, achieving "aging retardant" effects very similar to those of caloric restriction, including a suppression of mitochondrial superoxide generation. Although voluntary caloric restriction is never likely ...

journal_title：Medical hypotheses

authors： McCarty MF,Barroso-Aranda J,Contreras F

更新日期：2009-02-01 00:00:00

abstract：:The mechanism of dermatomyositis/polymyositis (DM/PM) is unknown. There are multiple probable trigger mechanisms. Internal malignancy is a specific trigger for some cases of DM/PM. It is known that there are marked changes in the extracellular matrix around tumors and that various fractions of depolymerized glycosamin...

journal_title：Medical hypotheses

authors： Stone OJ

更新日期：1993-07-01 00:00:00

abstract：:Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...

journal_title：Medical hypotheses

authors： Sprietsma JE

更新日期：1997-07-01 00:00:00

abstract：:Endophthalmitis following pars-plana procedures such as a vitrectomy vitreo-retinal procedures has been infrequently reported in literature. The cited incidence is about 0.1% to 0.2%. In the 8 cases of endophthalmitis that have been reported in literature, the prognosis has been indicated as very poor due to a delay i...

journal_title：Medical hypotheses

authors： Venkatesh P,Verma L,Tewari H

更新日期：2002-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...

journal_title：Medical hypotheses

authors： Polat K,Nour M

更新日期：2020-03-16 00:00:00

abstract：:Although it is well established that components of wheat gluten and structurally-related cereal proteins produce intestinal damage in Coeliac disease (CD), the primary defect which confers upon the host susceptibility to these dietary substances remains a mystery. To date, three main hypotheses have been framed to exp...

journal_title：Medical hypotheses

authors： Davidson AG,Bridges MA

更新日期：1988-07-01 00:00:00

abstract：:Stressful events occur in the lives of millions of individuals each year. Such events, or "stressors", are experiences that threaten personal well-being, and include traumatic events such as motor vehicle collision, infectious illness, and situations such as military deployment. While most individuals recover from suc...

journal_title：Medical hypotheses

authors： McLean SA,Clauw DJ

更新日期：2004-01-01 00:00:00

abstract：:Immunoreactive prolactin in high concentration was detected in the human semen. Therefore, the effect of prolactin on the various metabolic parameters of the human spermatozoa was studied. It was found that prolactin brought about many of the biochemical changes in the spermatozoa which are known to be associated with...

journal_title：Medical hypotheses

authors： Shah GV,Sheth AR

更新日期：1979-08-01 00:00:00

abstract：:The paper discusses the unifying concept that cell hydration is the primary factor in the mechanism of carcinogenesis. The concept includes the following hypotheses: (1) Increased cell hydration causes cancer not only by promoting cell division and oncogene expression, but also by inactivating genes inducing cell diff...

journal_title：Medical hypotheses

authors： McIntyre GI

更新日期：2006-01-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that occurs predominantly in children <5 years of age. For the etiopathogenesis of KD, there is no agreement even as to whether KD is an infectious disease or an immune-mediated disease. The epidemiologic characteristics of KD, including...

journal_title：Medical hypotheses

authors： Lee KY,Han JW,Lee JS

更新日期：2007-01-01 00:00:00

abstract：:ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal exp...

journal_title：Medical hypotheses

authors： Hoffman I,Saltzman B

更新日期：2003-04-01 00:00:00

abstract：:Trypanosomiasis (whether African sleeping sickness, or American Chaga's disease) is caused by an infection with a protozoan parasite, i.e. the trypanosome. This carries fatal sequences in the untreated host. Currently available chemotherapeutic drugs (some of which cure by involving reactive oxygen species (ROS] are n...

journal_title：Medical hypotheses

authors： Eze MO

更新日期：1991-11-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...

journal_title：Medical hypotheses

authors： Elkadi OA,Abdelbasset M

更新日期：2016-04-01 00:00:00

abstract：:An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic r...

journal_title：Medical hypotheses

authors： Gourov AV

更新日期：2011-12-01 00:00:00

abstract：:The review briefly describes the evolution of hypotheses about cronic thyroiditis, the escape of colloid hypothesis, basement membrane destruction, the auto-immune theory and the role of disregulatory genes. ...

journal_title：Medical hypotheses

authors： Stuart A

更新日期：2011-09-01 00:00:00

abstract：:There are many observations regarding the behaviour of melanoma which points away from sunshine as the main cause of this tumour. Incidence data shows that the increase is mostly seen for thin melanomas which cannot be attributed to sun exposure but increasing screening over the last 20 years. Melanoma behaves in a si...

journal_title：Medical hypotheses

authors： Bataille V

更新日期：2013-11-01 00:00:00

abstract：:So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring lat...

journal_title：Medical hypotheses

authors： Laumbacher B,Fellerhoff-Loesch B,Wank R

更新日期：2017-02-01 00:00:00