Abstract:
:Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson disease based on the acoustic features from the speech signals. In the proposed data sampling method, the one against all (OGA) has been used to divide the dataset into five equal parts. With applying the OGA to the PD dataset having two classes (healthy and Parkinson disease), the minority and majority classes have been obtained. First of all, for healthy class in the dataset (first case), five equal partitions have been composed and then for PD class in the dataset (second case), five equal partitions have been composed. To classify the these all data partitions, we have used three different classifiers including the weighted k-NN (nearest neighbor), Logistic Regression (LR), and support vector machine with medium Gaussian kernel function. In order to evaluate the performance of the proposed hybrid models (the combination of classifiers and OGA based data sampling), the classification accuracy, the confusion matrix, and area under the Receiver Operating Characteristic (ROC) curve (AUC) have been used. While the LR, SVM with Gaussian, and weighted k-NN classifiers achieved the classification accuracies of 77.50%, 83.80%, and 82.10% in the classification of PD with the acoustic features, the combinations of classifiers and OGA based data sampling (first case) obtained the 79.04%, 87.36%, and 88.48% using the LR, SVM with Gaussian, and weighted k-NN classifiers, respectively. In the second case, the obtained classification accuracies are the 84.30%, 88.76%, and 89.46% using the LR, SVM with Gaussian, and weighted k-NN classifiers with the OGA based data sampling, respectively. The achieved results have shown that the proposed the one against all (OGA) based data sampling could be used in the combination of classifier algorithms as the data pre-processing method in the classification of Parkinson's disease with acoustic features.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Polat K,Nour Mdoi
10.1016/j.mehy.2020.109678subject
Has Abstractpub_date
2020-03-16 00:00:00pages
109678eissn
0306-9877issn
1532-2777pii
S0306-9877(20)30318-2journal_volume
140pub_type
杂志文章abstract::Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothes...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.07.018
更新日期:2013-10-01 00:00:00
abstract::Random connection weight disturbances within an assembly of artificial neural networks (ANN) drive a progression of activation patterns that are tantamount to the memories and ideas nucleating within the brain's cortex. The numerical evaluation of these pattern-based notions by another, more placid system of ANNs gove...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.07.010
更新日期:2016-09-01 00:00:00
abstract::Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP ha...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.09.025
更新日期:2014-12-01 00:00:00
abstract::Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...
journal_title:Medical hypotheses
pub_type: 信件
doi:10.1016/j.mehy.2020.110244
更新日期:2020-10-01 00:00:00
abstract::Atherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109449
更新日期:2020-02-01 00:00:00
abstract::An unconventional interaction between a patient and parasites was recently reported, in which parasitic cells invaded host's tissues, establishing several tumors. This finding raises various intriguing hypotheses on unpredicted forms of interplay between a patient and infecting parasites. Here we present four unusual ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.06.012
更新日期:2016-09-01 00:00:00
abstract::The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.02.013
更新日期:2017-04-01 00:00:00
abstract::Bovine serum albumin and human serum transferrin modified by the water soluble carbodiimides N-ethyl-N'-(3-dimethyl propylamino) carbodiimide (CDI) or N-ethyl-N'-(3-trimethyl propylammonium) carbodiimide (Me+CDI) to yield N-acylurea proteins bind pBR322 DNA reversibly showing electrostatic and non-electrostatic compon...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90044-2
更新日期:1987-09-01 00:00:00
abstract::Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.04.012
更新日期:2016-06-01 00:00:00
abstract::Photodynamic therapy (PDT) is a new therapeutic approach for the treatment of malignant tumors. Hyperbaric oxygen (HBO(2)) shows beneficial effects in various modalities of cancer interventions. Tumor cells tend to accumulate large amount of iron. There is interaction between tissue content of oxygen, iron, free radic...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.12.052
更新日期:2006-01-01 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with pla...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.02.011
更新日期:2008-08-01 00:00:00
abstract::It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout th...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1140
更新日期:2001-03-01 00:00:00
abstract::A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy of positive a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1163
更新日期:2001-05-01 00:00:00
abstract::Mood expressions encompassing positive scales like "activity, elation, contemplation, calmness" and negative scales like "anger, excitement, depression, fatigue" were applied for introducing a new tool to assess the effects of acupuncture on brain structures. Traditional acupuncture points defined in the literature fo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.05.013
更新日期:2015-09-01 00:00:00
abstract::Geographic patterns with diminishing rates from north to south toward the equator have been described for a number of diseases, putatively related largely to "western" lifestyle. Among these the inflammatory bowel diseases; Crohn's (CD) and Ulcerative colitis (UC) have been prominent in sharing distributions with a nu...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.10.001
更新日期:2016-11-01 00:00:00
abstract::The mechanisms of fibroproliferation disease (FPD) of the skin, such as keloids and hypertrophic scars, are still unknown. Since mechanical stress appears to be an important factor for FPD generation, we have studied the intervening factors that connect mechanical stress with keloid and scar formation. Hence, we intro...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.01.032
更新日期:2008-01-01 00:00:00
abstract::Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.02.020
更新日期:2016-05-01 00:00:00
abstract::The concept of reentry as the most important element in a hypothesis for consciousness proposed by Edelman and Tononi is reviewed. Reentry, is a process of ongoing parallel and recursive signalling between separate neuronal groups along parallel reciprocally fibers that link these groups anatomically. Reentry alters t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.007
更新日期:2004-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common neurodegenerative disease and oligodendrocyte degeneration and white matter damage play a critical role in the pathogenesis of AD. FGF/FGF receptor signaling have been implicated in diverse cellular processes including cell apoptosis, survival, adhesion, migration, different...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.12.008
更新日期:2013-04-01 00:00:00
abstract::The author, in an attempt to clarify whether the rise of alternative medicine is a phenomenon characteristic of our time or whether it existed in the past as well, has identified at least three alternative medicines, which developed in ancient Rome, ancient India and in the medieval Islamic world. The circumstances le...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1054/mehy.2000.1061
更新日期:2000-10-01 00:00:00
abstract::Hepatic encephalopathy (HE) is a common neuropsychiatric complication of liver disease affecting about 20-30% patients with cirrhosis. HE may only affect quality of life (e.g. impairments in attention; coordination; driving ability), but in some patients this progresses to coma and death; defining mortality in those w...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.12.061
更新日期:2007-01-01 00:00:00
abstract::This paper treats evidence for an increasing recognition of a force with intangible properties in biosystems with special reference to its ability to transport electrons at near 0 degree Kelvin. It is implied that such force, whose demonstration at these temperatures is an experimental contrivance to emphasise its str...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90517-0
更新日期:1995-06-01 00:00:00
abstract::So-called 'limited life span' of diploid cells does not depend on their unresponsiveness to growth factors from the data obtained by complete protein-free culture of tumor cells. Limited proliferation (called limited life span) of diploid cells is one of the 'ad-hoc' negative regulatory mechanisms in animals, and can ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90090-d
更新日期:1993-10-01 00:00:00
abstract::At present no good method of assisting the right ventricle of the heart exists. This paper presents a new and effective approach to assisting the right ventricle of the heart which can be utilized independently or during cardiac surgery. Through implementation of this method, and timed inflation and deflation of sever...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90003-3
更新日期:1979-11-01 00:00:00
abstract::The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00013-6
更新日期:2003-04-01 00:00:00
abstract::Several experiments show that there is a cell to cell communication by light in different cell types. This article describes theoretical mechanisms and subcellular structures that could be involved in this phenomenon. Special consideration is given to the nervous system, since it would have excellent conditions for su...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/S0306-9877(03)00308-6
更新日期:2004-01-01 00:00:00
abstract::A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.02.003
更新日期:2017-04-01 00:00:00
abstract::Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/s0306-9877(97)90065-7
更新日期:1997-12-01 00:00:00
abstract::Hyperuricemia has been labeled both a risk factor and marker for cardiovascular pathology in addition to being associated with gout and kidney disease. Uric acid in vitro acts as a potent antioxidant capable of scavenging hydroxy radicals and peroxynitrite and reacting with nitric oxide. Some clinical studies have pro...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1221
更新日期:2001-06-01 00:00:00
abstract::There is a striking resemblance, in amino-acid composition and properties, between one class of structural glycoproteins from connective tissue and the apo low density lipoproteins (LDL) of blood plasma. It is suggested that there is a structurally specific analogy between the early atherogenic accumulation of LDL (an...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(76)90039-6
更新日期:1976-09-01 00:00:00