The extinction program for Homo sapiens and cloning humans: trinucleotide expansion as a one-way track to extinction.

abstract：:Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and a...

journal_title：Medical hypotheses

authors： More N,Kapusetti G

更新日期：2017-10-01 00:00:00

abstract：:Ever since antimicrobial therapy was introduced, two phenomenons have been observed: drug resistance and host toxicity. Mutation(s) in microbes leads to the earlier, while off target effects of therapy cause the latter. Neither of these problems have yet to be resolved. All Microbes express specific antigens, against ...

journal_title：Medical hypotheses

authors： Singla M

更新日期：2007-01-01 00:00:00

abstract：:The natural tibiofemoral joint (TFJ) functions according to the asymmetrical joint surfaces and the rolling-gliding mechanism. In the sagittal section, the human TFG is the tibial plateau on the medial concave side and curved on the lateral convex. With the asymmetrical joint surfaces, the flexion of the knee consists...

journal_title：Medical hypotheses

authors： Wei H,Lu W,Niu S,Tian F,Tian H,Ni Y

更新日期：2014-09-01 00:00:00

abstract：:Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militar...

journal_title：Medical hypotheses

authors： Cappello F,Macario AJL

更新日期：2019-03-01 00:00:00

abstract：:A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...

journal_title：Medical hypotheses

authors： Verlangieri AJ,Kapeghian JC,el-Dean S,Bush M

更新日期：1985-01-01 00:00:00

abstract：:The current epidemic of obesity has developed at a rate that cannot be attributed to genetic drift. Attempts to treat obesity using diet and activity have been largely disappointing. Genes are fixed at conception, but genetic expression is known to be influenced by nutriture during the stages of growth and development...

journal_title：Medical hypotheses

authors： Blonz ER

更新日期：2006-01-01 00:00:00

abstract：:Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...

journal_title：Medical hypotheses

authors： Healy D

更新日期：2010-05-01 00:00:00

abstract：:Many parasites induce characteristic changes in their host. The effect of Toxoplasma gondii infection on the cerebrum and neuropsychiatric patients has been increasingly emphasized in recent years. T. gondii has a high affinity for brain tissue where tachyzoites may form tissue cysts and persist for a life long time. ...

journal_title：Medical hypotheses

authors： Zhu S

更新日期：2009-11-01 00:00:00

abstract：:Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progr...

journal_title：Medical hypotheses

authors： Ali ZA,El-Mallakh RS

更新日期：2020-11-01 00:00:00

abstract：:There are differences in male and female height throughout the growth period. Utilising reference standard height charts we calculated the difference in male and female height as a function of age. A triphasic relationship was observed with statistically significant peaks (males greater than females) at 8 months and 1...

journal_title：Medical hypotheses

authors： Schreiber G,Baron B

更新日期：1984-07-01 00:00:00

abstract：:Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

journal_title：Medical hypotheses

authors： Biran H,Ariel I,De Groot N,Hochberg A

更新日期：1994-08-01 00:00:00

abstract：:Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than card...

journal_title：Medical hypotheses

authors： Li LD,Zhang CT,Ruan L,Ni MK,Quan XQ

更新日期：2011-01-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00

abstract：:The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single l...

journal_title：Medical hypotheses

authors： Åm MK,Fougner AL,Ellingsen R,Hjelme DR,Bösch PC,Stavdahl Ø,Carlsen SM,Christiansen SC

更新日期：2019-11-01 00:00:00

abstract：:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocul...

journal_title：Medical hypotheses

authors： Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

更新日期：2020-11-01 00:00:00

abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...

journal_title：Medical hypotheses

authors： O'Kennedy N,Duttaroy AK

更新日期：2021-01-04 00:00:00

abstract：:Researchers have recently reported a possible inverse relationship between taking steroids or non-steroidal anti-inflammatory drugs, or both, and the development of Alzheimer's disease. In this article it is hypothesized that the reduction in the human body of the amount of available arachidonic acid, the precursor of...

journal_title：Medical hypotheses

authors： Newman PE

更新日期：1998-04-01 00:00:00

abstract：:For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attr...

journal_title：Medical hypotheses

authors： Mainardi P,Albano C

更新日期：2008-01-01 00:00:00

abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...

journal_title：Medical hypotheses

authors： Du Toit PJ,Theron JJ,Grobler AS,Steinmann CM,Van Papendorp DH

更新日期：1996-09-01 00:00:00

abstract：:Condylar cartilage is absolutely necessary for the normal function of temporomandibular joint (TMJ). Unfortunately, condylar cartilage defect or missing is also one of the common clinical problems. Repair or reconstruction of cartilage is always a hot topic. Cell based cartilage regeneration is suggested as novel ther...

journal_title：Medical hypotheses

authors： Dai J,Wang X,Shen G

更新日期：2011-07-01 00:00:00

abstract：:Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (espec...

journal_title：Medical hypotheses

authors： Kowara M,Kasarełło K,Czarzasta K,Opolski G,Cudnoch-Jędrzejewska A

更新日期：2019-01-01 00:00:00

abstract：:I hypothesize that the intermediates of the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) degradation kynurenic acid (KA) and quinolinic acid (QA) play opposite roles in inflammatory diseases, with KA being antiinflammatory and QA being immunosuppressant. Darlington et al. have demonstrated a decrease in the ratio...

journal_title：Medical hypotheses

authors： Badawy AA

更新日期：2018-09-01 00:00:00

abstract：:Reversing chronic conditions remains an elusive goal of medicine. The modern medical paradigm based on blocking overactive pathways or augmenting deficient pathways offers symptomatic benefit, but tolerance to therapy can develop and treatment cessation can produce rebound symptoms due to compensatory mechanisms. We p...

journal_title：Medical hypotheses

authors： Yun AJ,Lee PY,Bazar KA

更新日期：2005-01-01 00:00:00

abstract：:The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...

journal_title：Medical hypotheses

authors： Asencio JM,Vaquero J,Olmedilla L,García Sabrido JL

更新日期：2013-05-01 00:00:00

abstract：:Parkinson disease (PD) is a chronic progressive degenerative disorder that affects over 6 million people worldwide. It is manifested by motor and psychiatric signs. The latter inflicts up to 88% of PD patients. With the prolongation of life expectancy, it is presumed that the prevalence of PD will further rise, togeth...

journal_title：Medical hypotheses

authors： Raskin S,Durst R

更新日期：2010-12-01 00:00:00

abstract：:The universal 24-hour circadian clock has a profound impact on many daily biological processes. Disturbance of circadian rhythms has been implicated in the etiologies of many chronic illnesses, including cancer; with correlations most profoundly found among hormone-related breast and prostate cancers. Given the fact t...

journal_title：Medical hypotheses

authors： Zhu Y,Zheng T

更新日期：2008-01-01 00:00:00

abstract：:A nutraceutical that has exploded onto the prescription pad in recent years is the fat soluble vitamin, vitamin D. This is due to an increasing medical interest in the utility of the vitamin in the treatment and prevention of an array of diseases and ailments. Despite the continued debate over the correct dose, form a...

journal_title：Medical hypotheses

authors： Braithwaite MC,Kumar P,Tyagi C,Tomar LK,Choonara YE,Pillay V

更新日期：2013-10-01 00:00:00

abstract：:We present a plausible and powerful explanation for nicotine addiction that is consistent with recent findings. Sleep apnea, the periodic cessation of breathing during sleep, may be responsible for the addictive nature of nicotine. The main symptoms of sleep apnea are somnolence and obesity. Nicotine has been shown to...

journal_title：Medical hypotheses

authors： Schrand JR

更新日期：1996-12-01 00:00:00

abstract：:Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the largest current health challenge for the society. At the moment, the therapeutic strategies to deal with this disease are only supportive. It is well known that zinc (Zn) possesses a variety of dir...

journal_title：Medical hypotheses

authors： Kumar A,Kubota Y,Chernov M,Kasuya H

更新日期：2020-11-01 00:00:00

abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...

journal_title：Medical hypotheses

authors： Li J,Wang B,Liu P

更新日期：2008-08-01 00:00:00