Is the antiepileptic effect of the ketogenic diet due to ketones?

Abstract:

:For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attributed to accumulation of ketones, and there are experimental data in animal models to support this hypothesis. Recently, new data about the neuroendocrine response to the acute phase reaction (stress) have emerged, indicating involvement of various neuropeptides, including neuropeptide Y (NPY), which is considered as an endogenous anticonvulsant. The release of NPY is also stimulated by nutrients in the gut, particularly fats. Long-chain and, to a greater extent, medium-chain triglycerides, which are components of the ketogenic diet, stimulate NPY secretion. This effect may explain the improvement in seizure control after starvation, use of the classical ketogenic diet, and use of the MCT diet.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Mainardi P,Albano C

doi

10.1016/j.mehy.2007.05.054

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

536-9

issue

3

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(07)00462-8

journal_volume

70

pub_type

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