Abstract:
:For many years, the ketogenic diet, including recent variants such the medium-chain triglyceride (MCT) diet, has been used with good clinical results in the management of refractory epilepsies, particularly in children. The antiepileptic effects of the diet, like the antiepileptic effects of starvation, have been attributed to accumulation of ketones, and there are experimental data in animal models to support this hypothesis. Recently, new data about the neuroendocrine response to the acute phase reaction (stress) have emerged, indicating involvement of various neuropeptides, including neuropeptide Y (NPY), which is considered as an endogenous anticonvulsant. The release of NPY is also stimulated by nutrients in the gut, particularly fats. Long-chain and, to a greater extent, medium-chain triglycerides, which are components of the ketogenic diet, stimulate NPY secretion. This effect may explain the improvement in seizure control after starvation, use of the classical ketogenic diet, and use of the MCT diet.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Mainardi P,Albano Cdoi
10.1016/j.mehy.2007.05.054subject
Has Abstractpub_date
2008-01-01 00:00:00pages
536-9issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00462-8journal_volume
70pub_type
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