Abstract:
:Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (especially an imbalance between pro- and anti-inflammatory macrophages) triggers a "butterfly effect" within the arterial wall by initiating a sequence of processes that finally leads to atherosclerotic plaque development and progression. Therefore, pharmacological and non-pharmacological interventions aimed to prevent atherosclerosis development should be applied not only in the adult population over 40 years old (according to current American and European guidelines) but should start in early life.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Kowara M,Kasarełło K,Czarzasta K,Opolski G,Cudnoch-Jędrzejewska Adoi
10.1016/j.mehy.2018.10.026subject
Has Abstractpub_date
2019-01-01 00:00:00pages
106-110eissn
0306-9877issn
1532-2777pii
S0306-9877(18)30788-6journal_volume
122pub_type
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