Immune modulation and disease patterns in population groups.

abstract：:Researchers have recently reported a possible inverse relationship between taking steroids or non-steroidal anti-inflammatory drugs, or both, and the development of Alzheimer's disease. In this article it is hypothesized that the reduction in the human body of the amount of available arachidonic acid, the precursor of...

journal_title：Medical hypotheses

authors： Newman PE

更新日期：1998-04-01 00:00:00

abstract：:During the last 10 years, we have witnessed major progress in the genetic study of schizophrenia, but gene-mapping efforts have been hampered by the complex mode of inheritance and the likelihood of multiple genes of small effect. In view of the complexity, it may be instructive to understand the biological bases for ...

journal_title：Medical hypotheses

authors： Peng ZW,Chen XG,Wei Z

更新日期：2007-01-01 00:00:00

abstract：:There are many observations regarding the behaviour of melanoma which points away from sunshine as the main cause of this tumour. Incidence data shows that the increase is mostly seen for thin melanomas which cannot be attributed to sun exposure but increasing screening over the last 20 years. Melanoma behaves in a si...

journal_title：Medical hypotheses

authors： Bataille V

更新日期：2013-11-01 00:00:00

abstract：:Preterm birth is an important perinatal health problem. Several possible mechanisms have been proposed but it may be important to have a testable mechanistic hypothesis that can explain the possible common mechanism for preterm births around the globe. Altered metabolism of micronutrients, like folic acid, vitamin B(1...

journal_title：Medical hypotheses

authors： Sundrani DP,Chavan Gautam PM,Mehendale SS,Joshi SR

更新日期：2011-11-01 00:00:00

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：:The present analysis addresses the question of how it has been possible for academic medicine to grow and lose its creative productivity at the same time. A mathematical model is developed to simulate the mechanisms that govern growth of medical systems over time. Time-dependent growth of system size increases the occ...

journal_title：Medical hypotheses

authors： Sonnenberg A

更新日期：2005-01-01 00:00:00

abstract：:The assumption is introduced that there are two types of adaptive responses in central neurons in response to significantly changed circuit activity. Morphological synaptic modifications and synapse turnover are thought to be involved in both of these responses, in such a way that in the first case they are to restore...

journal_title：Medical hypotheses

authors： Benusková L

更新日期：1991-05-01 00:00:00

abstract：:The repair and reconstruction of tissue defects and organ loss are severe problems, and many patients are eager to find avenues to these matters. Up until now, the number of methods used to repair tissue defects has increased, but all of these have their own advantages and inconveniences, and do not seem to have been ...

journal_title：Medical hypotheses

authors： Yang M,Liu L

更新日期：2008-01-01 00:00:00

abstract：:While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, th...

journal_title：Medical hypotheses

authors： Rastam S,Li FM,Fouad FM,Al Kamal HM,Akil N,Al Moustafa AE

更新日期：2010-03-01 00:00:00

abstract：:Puberty is starting earlier than ever before and there are serious physiological and sociological implications as a result of this development. Current research has focused on the potential role of high caloric, and commensurate high adiposity, contributions to early puberty. However, girls with normal BMI also appear...

journal_title：Medical hypotheses

authors： Pitynski D,Flynn FW,Skinner DC

更新日期：2015-10-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to have a higher incidence of cancer. It is suggested that several factors, including hyperinsulinemia, dyslipidemia, raised estrogen levels, chronic inflammation, and reduced apoptosis are responsible for this association. However, in this paper we propose t...

journal_title：Medical hypotheses

authors： Mravec B,Tibensky M

更新日期：2020-01-01 00:00:00

abstract：:Aspirin, today, is an established drug in the regime for the prevention of myocardial infarction, especially in high-risk groups. This use of aspirin has given it a new lease of life in its tenth decade of clinical use. Aspirin is probably the oldest synthetic drug in the Pharmacopoeias today; thus one would have imag...

journal_title：Medical hypotheses

authors： Ghooi RB,Thatte SM,Joshi PS

更新日期：1995-02-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:The weight of available evidence suggests that leukaemogenesis is a multi-step, complex process. Since there are different types of leukaemia, it seems likely that a variety of distinct molecular mechanisms are involved, arising from different combinations of genetic defects. It is not therefore surprising that studie...

journal_title：Medical hypotheses

authors： Francis GE

更新日期：1987-03-01 00:00:00

abstract：:The function of the gallbladder is questioned in a hypothesis postulating that all bile which enters this reservoir is totally absorbed to the liver and none of it flows back to the cystic duct and duodenum. Cholecystokinesis is believed to increase and maintain a gradient of intravesical pressure which increases the ...

journal_title：Medical hypotheses

authors： Al-Hilli F

更新日期：1986-10-01 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...

journal_title：Medical hypotheses

authors： Reid GM,Tervit H

更新日期：1999-06-01 00:00:00

abstract：:In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...

journal_title：Medical hypotheses

authors： Krommydas G,Gourgoulianis KI,Andreou G,Kotrotsiou E,Raftopulos V,Paralikas T,Molyvdas PA

更新日期：2004-01-01 00:00:00

abstract：:Mild traumatic brain injury, often referred to as concussion, is a common, potentially debilitating, and costly condition. One of the main challenges in diagnosing and managing concussion is that there is not currently an objective test to determine the presence of a concussion and to guide return-to-play decisions fo...

journal_title：Medical hypotheses

authors： Cartwright MS,Dupuis JE,Bargoil JM,Foster DC

更新日期：2015-09-01 00:00:00

abstract：:This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadv...

journal_title：Medical hypotheses

authors： Siefkes D

更新日期：1993-10-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:Schmorl's nodes (SNs) are common abnormalities in the human spine, which represent herniation of the nucleus pulposus of the intervertebral disc into the adjacent cartilaginous endplate of the vertebra. However, the principle mechanism of SNs is still not fully understood. And the relationship of SNs in the spine and ...

journal_title：Medical hypotheses

authors： Zhang N,Li FC,Huang YJ,Teng C,Chen WS

更新日期：2010-03-01 00:00:00

abstract：:Human endometrium is a highly regenerative tissue and contains a low number of cells which have high replicative ability and differentiation efficiency. This has been identified by many scientists. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capab...

journal_title：Medical hypotheses

authors： Zhang MJ,Liu B,Xia W,Sun ZY,Lu KH

更新日期：2009-03-01 00:00:00

abstract：:Although once considered by biologists almost exclusively for their toxicity, reactive oxygen (ROS) and nitrogen (RNS) species produced within normal cells under baseline physiological conditions are now appreciated as redox regulators of a wide range of protein functions. Two families of enzymes, the NADPH oxidases (...

journal_title：Medical hypotheses

authors： Stuart JA,Aibueku O,Bagshaw O,Moradi F

更新日期：2019-08-01 00:00:00

abstract：:This study investigated whether or not the anesthetic effect of ketamine in rats is dependent on adrenal gland hormones. The study was performed on two main rat groups, intact and adrenalectomized. Rat were divided into subgroups and given appropriate doses of ketamine, metyrapone or metyrosine. Durations of anesthesi...

journal_title：Medical hypotheses

authors： Aksoy M,Ince I,Ahiskalioglu A,Dostbil A,Celik M,Turan MI,Cetin N,Suleyman B,Alp HH,Suleyman H

更新日期：2014-07-01 00:00:00

abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...

journal_title：Medical hypotheses

authors： Levy M,Ehrenfeld M,Gallily R,Eliakim M

更新日期：1981-01-01 00:00:00

abstract：:I have previously assumed that stem tumour cells are 'para-embryonal cells' (PECs) poor or missing in major histocompatibility complex (MHC) antigens. PECs might induce adjoining differentiated hyperplastic cells to also express tumoral phenotype and properties, thus transforming them into 'differentiated para-embryon...

journal_title：Medical hypotheses

authors： Manzo G

更新日期：1998-05-01 00:00:00

abstract：:The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several in...

journal_title：Medical hypotheses

authors： Walton RG,Monte WC

更新日期：2015-10-01 00:00:00

abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...

journal_title：Medical hypotheses

authors： Visser JJ,Hoekman K

更新日期：1994-11-01 00:00:00

abstract：:Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...

journal_title：Medical hypotheses

authors： Ozdemir F,Ari A,Kilcik MH,Hanbay D,Sahin I

更新日期：2020-10-01 00:00:00

abstract：:In this study, after having formed the hypothesis of the existence of a "Compensating Center" (cerebral?) that orders the increase in the function of one kidney in case of deterioration of its congener, we propose two mechanisms that may lead to the activation of this Center. The first may be the difference between th...

journal_title：Medical hypotheses

authors： Collard M

更新日期：1988-03-01 00:00:00