Abstract：
:While cigarette smoking is recognized as an important risk factor in human oral cancers, the effect of water pipe smoking (WPS) on these cancers is not known. WPS is very common in the young adult population, especially in the Middle East, and has been associated with several respiratory problems. However, to date, there have been no studies examining the association between WPS and the progression of human oral cancers. Currently, the role of WPS in human oral cancers remains uncertain because of the limited number of investigations. This raises the question of whether WPS plays a significant role in the development of human oral carcinomas. In this paper, we propose the hypothesis that human oral normal epithelial cells are vulnerable to persistent WPS; moreover, WPS could play an important role in the initiation of a neoplastic transformation of human normal oral epithelial cells. Therefore, we believe that an international collaboration of epidemiological and clinical studies as well as cellular and molecular biology investigations is necessary to answer this important question.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Rastam S,Li FM,Fouad FM,Al Kamal HM,Akil N,Al Moustafa AEdoi
10.1016/j.mehy.2009.10.013subject
Has Abstractpub_date
2010-03-01 00:00:00pages
457-9issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(09)00688-4journal_volume
74pub_type
杂志文章abstract：:Body size and body composition have been suggested as the best explanation for the temporal trend toward early menarche over the last 100 years. There is evidence from human and animal studies that indicates that body size is not the primary factor in influencing the occurrence of menarche. The data actually show that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90124-9
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:No method is currently available for preoperative approximation of the patient's situation to the one existing during pneumonectomy in general anesthesia with alternations of single and double-lung ventilation in the lateral position. We hypothesized that a patient breathing the room air in the sitting posit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.07.003
更新日期：2011-10-01 00:00:00
abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110374
更新日期：2021-01-01 00:00:00
abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.08.029
更新日期：2011-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.091
更新日期：2007-01-01 00:00:00
abstract：:The clinical syndrome of hypoxic ischemic encephalopathy (HIE) which occurs in association with birth asphyxia, is thought to represent a reperfusion injury consequent upon the generation of cytotoxic oxygen derived free radicals. It has recently been suggested that resuscitation of asphyxiated infants with unrestrict...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90080-a
更新日期：1993-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2015.09.008
更新日期：2015-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.01.001
更新日期：2012-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.04.022
更新日期：2013-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.04.043
更新日期：2013-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0896
更新日期：2000-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.04.020
更新日期：2012-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 传,历史文章,杂志文章
doi：10.1054/mehy.1998.0777
更新日期：1999-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90102-4
更新日期：1980-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.12.030
更新日期：2010-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109790
更新日期：2020-04-24 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.05.004
更新日期：2014-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.11.018
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.009
更新日期：2015-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.017
更新日期：2004-01-01 00:00:00
abstract：:The apparent association of laryngeal cancer with asbestos and possibly other occupational exposures can be accounted for by the hypothesis that chronic vocal abuse peculiar to certain working conditions will act as a promoting factor for active carcinogens found mainly in tobacco smoke. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90050-5
更新日期：1981-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109545
更新日期：2020-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0907
更新日期：2000-04-01 00:00:00
abstract：:Acute disseminated encephalomyelitis (ADEM) is defined as a multifocal, monophasic, demyelinating, and inflammatory disease involving the central nervous system. It typically begins within 6 weeks of an antigenic challenge such as infection or immunization. Perivenous inflammation, edema and demyelination are the path...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.10.061
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90090-4
更新日期：1988-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90267-5
更新日期：1998-06-01 00:00:00
abstract：:Review of 18th and 19th century psychiatric therapies raises the possibility that several may have altered the activity of vasopressin or Na-K-ATPase. Bleeding, whirling, nausea created by medicines, and vagus nerve stimulation by application of electricity through the skin all perturb the hypothalamic hormone, argini...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/j.mehy.2003.10.007
更新日期：2004-01-01 00:00:00
abstract：:The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.046
更新日期：2009-11-01 00:00:00
abstract：:In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90194-h
更新日期：1992-04-01 00:00:00
abstract：:Lipid peroxidation has been shown to both enhance carcinogenesis and to have an anticarcinogenic effect. This paradox is of great relevance to the fields of free radical biology, biochemistry, pathology, nutrition and oncology among others and needs to be addressed. A proper understanding of this issue can be a key to...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90120-6
更新日期：1996-06-01 00:00:00
